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排序方式: 共有8391条查询结果,搜索用时 31 毫秒
51.
MOTOYOSHI NOMIZU YOSHIMASA INAGAKI TAKEYOSHI YAMASHITA AKO OHKUBO AKIRA OTAKA NOBUTAKA FUJII PETER P. ROLLER HARUAKI YAJIMA 《Chemical biology & drug design》1991,37(2):145-152
A new two-step deprotection/cleavage procedure for t-butoxycarbonyl (Boc) based solid phase peptide synthesis is reported. First the protective groups are removed from 4-(oxymethyl)-phenylacetamidomethyl (PAM) resin attached peptide with the weak hard acid, trimethylsilyl bromide-thioanisole/trifluoroacetic acid (TFA). In the second step, the peptide is cleaved from the resin with a stronger hard acid such as trimethylsilvl trifluoromethanesulfonate in TFA or with HF. The method is also shown to deformylate Nin-formyltryptophan moiety efficiently. The usefulness of this procedure for practical solid phase peptide synthesis is demonstrated by comparison with other deprotection methods in the synthesis of urotensin II and human endothelin. 相似文献
52.
A 32-year-old man with distal skeletal manifestations of Marfan's syndrome had experienced shortness of breath and orthopnea for one month. Physical examination showed the presence of severe aortic regurgitation. Both noninvasive and invasive studies revealed that the aortic regurgitation was induced by previously undescribed peculiar and unusual etiology: diastolic prolapse of a circumferentially dissected tubular intimal flap into the left ventricle. The patient underwent surgical repair with striking clinical improvement. 相似文献
53.
Combined percutaneous antegrade and cystoscopic retrograde approach in the treatment of distal ureteric fistulae 总被引:1,自引:1,他引:0
Thierry de Baere Alain Roche Christine Lagrange Alban Denys Bernard Court Joël Isapoff Paris Pappas 《Cardiovascular and interventional radiology》1995,18(6):349-352
Purpose To determine the efficacy of a cystoscopic approach, as definitive treatment of ureteral fistulae, after failure of antegrade ureteral stent insertion.Methods Of 43 ureter fistulae encountered over 4 years, 10 postoperative and/or postradiotherapy fistulae could not be stented via an antegrade approach alone. A cystoscopic approach was used, with the antegrade approach available as back-up, if necessary.Results In two patients the ureteral orifice could not be visualized cystoscopically, thus precluding the retrograde approach. In the eight remaining patients, the retrograde approach alone never allowed successful stenting. In six patients, combined antegrade and retrograde approaches permitted stent insertions. In three of those six patients, a complex catheterization procedure was necessary. In two patients the combined approach failed altogether. Therefore, 6 of 10 patients underwent a successful stenting procedure with the combined approach; all ultimately closed the fistula.Conclusion Antegrade stent insertion remains the treatment of choice for ureteral leaks. If the antegrade approach fails, the retrograde approach alone is not likely to be successful. Instead, a combination of both approaches often does succeed. 相似文献
54.
I.J. Clifton A.M. Morton N.S. Ambrose D.G. Peckham S.P. Conway 《Journal of cystic fibrosis》2004,3(4):273-275
We report a case of a patient with CF who had a long history of recurrent distal intestinal obstruction syndrome. She had been treated with conventional treatment including gastrografin, n-acetyl cysteine, Klean prep and Picolax. She underwent a modified antegrade continence enema procedure. She currently irrigates her conduit every 2-3 days. She has had no further symptoms of distal intestinal obstruction syndrome. 相似文献
55.
Munetaka Masuda Yoshihisa Tanoue Takurou Ohno Ryuji Tominaga 《European journal of cardio-thoracic surgery》2006,29(6):1056-1058
Damus–Kaye–Stansel procedure is a useful method to relieve the systemic ventricular outflow tract obstruction in functionally univentricular heart. Regurgitation of pulmonary valve and recurrence of systemic ventricular outflow obstruction are the major concerns at the late phase of this procedure. Modification of original Damus–Kaye–Stansel procedure that can prevent the use of prosthetic materials is evaluated. The modified Damus–Kaye–Stansel procedure using aortic flap technique was performed in eight patients with functionally univentricular heart. Patients’ ages ranged from 3 to 28 months (mean 14 months). Follow-up period was 37 months as a mean (9–71 months), and the follow-up was complete. There was no operative mortality and no late death. In addition, there was no recurrence of systemic ventricular outflow tract obstruction throughout the follow-up period. Regurgitation of the pulmonary valve estimated by echocardiography at the latest follow-up was none to trivial in seven patients and mild in one. The modified Damus–Kaye–Stansel procedure using aortic flap technique is a safe, useful and reproducible technique to solve systemic ventricular outflow tract obstruction in functionally univentricular heart, and it can be an alternative for original technique or the so-called double-barrel modification. 相似文献
56.
Nucleic acid spot hybridization with nonradioactive labeled probes in screening for human papillomavirus DNA sequences 总被引:1,自引:0,他引:1
We examined 161 human tissue samples using the spot hybridization technique with nonradioactive labeled DNA probes of human papillomavirus (HPV). Whole cells were spotted on nitrocellulose filters; DNA of the cells was denatured and fixed to the filter. Then the DNA spots were hybridized to nonradioactive labeled DNA and monitored by a sandwich immunoenzymatic reaction. This technique is simple, sensitive, specific, requires no special equipment, and can be used in clinical settings. HPV DNA was found in 92% of samples in which, on the basis of histologic and colposcopic criteria, its presence was suspected, as well as in 31 samples where it was not suspected. 相似文献
57.
F. Benfenati L. F. Agnati K. Fuxe 《Journal of neural transmission (Vienna, Austria : 1996)》1988,71(2):143-158
Summary Experimentally induced changes in neurotransmitter receptors have been analyzed by means of a computer assisted simulation procedure over a wide range of free ligand concentrations. This approach allows to evaluate, for a given range of ligand concentrations, the relative influence of simultaneous variations in binding parameters (i.e. dissociation constant or Kd and in maximal number of binding sites or Bm) and to predict the net and final effect of the experimental condition on the receptor-mediated transmission line. The function representing the changes in bound values versus the respective free ligand concentrations, has been studied analytically on the basis of all the possible values that the percent changes in both Kd and Bm parameters induced by a given experimental condition can assume. A well characterized change in the pattern of bound radioligand could in this way be defined. This approach, developed to show in an immediate and clear way treatment-induce changes in receptor populations or to fit directly rough experimental data expressed as differences in bound values versus free ligand concentrations, seems to be an useful complement to the widely used saturation analysis of binding data. 相似文献
58.
目的:探讨CT导引下经皮肺穿刺活检术围手术期的护理程序及注意事项。方法:对我院2007年11月至2009年7月63例行CT导引下经皮肺穿刺活检术的患者实施术前、术中、术后护理及健康指导等围手术期护理程序。结果:实施围手术期护理程序后,患者焦虑程度明显减轻,并发症明显减少,术后恢复良好,患者均安全度过围手术期。结论:认真落实护理程序各阶段的护理措施,是减少CT导引下经皮肺穿刺活检术围手术期意外和各种护理并发症的关键。应用围手术期护理程序可提高手术的护理质量,减少术后并发症,为患者迅速康复奠定良好的基础。 相似文献
59.
Yoichi Kikuchi Taku Sakurada Masato Suzuki Tomoyasu Hirano Katsuyuki Kusajima 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2004,52(8):375-378
Off-pump coronary artery bypass grafting has become an attractive surgical alternative for myocar-dial revascularization because
of the advantage of myocardial protection and other benefits of patients. However, it is still regarded as a controversial
treatment for the coronary artery disease accompanied by atrial fibrillation (AF). A significant number of patients in need
of coronary revascularization have chronic AF. Although the Cox-Maze III procedure is the gold standard for the surgical treatment
of AF, few of these patients undergo AF operations at the time of their coronary bypass grafting. We report herein a case
of the pulmonary vein isolation to eliminate the AF by means of epicardial radiofrequency ablation combined with 2 vessels
coronary artery bypass grafting on the beating heart with the aid of cardiopulmonary bypass. 相似文献
60.