L’adolescent aux diagnostics multiples ou le trouble dissociatif de l’identité à l’adolescence

ObjectiveTo evoke the notion of dissociative identity disorder in adolescence requires a nuance so many questions arise among others on the relevance of the juxtaposition of a complex disorder fluctuating at an age group marked by transition. In other words, is it appropriate to speak of dissociation of identity or multiple personality at this specific time of existence? It should also be noted that this diagnosis is controversial both because there is no consensus on definitions such as personality or identity and because some cultures take into account the possibility of possession to explain these tables without reference to pathology.MethodsTo illustrate our point, we will draw on the situation of a young person admitted to our institutional therapy centre located in a general hospital. The structure accommodates young people aged between fourteen and twenty for six to nine months. As we have also developed, these are usually directed in the course of ambulatory and/or residential therapeutic follow-ups, after experiencing moments of crisis or decompensation. The evaluation then carried out consolidates the prospect of a medium-term stay in a psychotherapeutic centre before considering a possible reintegration into daily life and activities. This clinical case illustrating the path of a teenager in prey to the tumults of wobbling of his identity causing confusion and uncertainty in the chief of the professionals encountered. The difficult situation experienced by this young person and his family questions on the one hand the relevance, the very basis of the diagnosis at this time of existence and on the other the notion of dissociative identity disorder in adolescence.ResultsThe dissociative identity disorder meets a number of criteria, the first of which is identity disturbance characterized by several distinct personality states. Clinically, we first observe a discontinuity in the integration of consciousness, of self-meaning. Registers of affects and sensory-motor functioning (perception, representation of the body) are also concerned. There are then disturbances of the agentivity (motor control, behaviors). In some cases, non-epileptogenic seizures and other conversive manifestations may be at the forefront of these complex clinical tables. The dissociative disorder of identity is also noticed by memory failures (dissociative amnesia) concerning the recall of daily events, personal information, which do not correspond to ordinary forgetfulness. This then leads to signs of impairment of social, professional or other relational functioning. Being an interruption in the tranquility of growth, adolescence is characterized by extreme conflicting positions, changing, fluctuating that give this period of life its appearance of tumult and crisis without being able to speak of frank psychic disturbances. Differential diagnosis between teen upheaval and true pathology is a difficult task.ConclusionsConsequently, we think it is important to pay attention to the diachronic and synchronic litters of what the young person in question is deploying. In order to do so, we advocate repeated clinical interviews with the patient and his or her entourage beside rigorous anamnesis. Time is an important element, the time of observation and encounter. Let us avoid precipitation without adopting an attitude of fatalism or even laxity, recalling that, for Winnicott, there is only one remedy for adolescence and only one; it is the passing time and gradual maturation processes that ultimately lead to the appearance of the adult person. Accompany a dissociative identity disorder, proven or suspected, includes the mobilization of a partnership envelope involving experienced institutional structures ready for the necessary clinical flexibility allowing continuous therapeutic adjustment.     

老年特应性皮炎：一个新的临床亚型

【摘要】 特应性皮炎是一种高度异质性的皮肤病，近年来疾病精准分型的研究揭示了特应性皮炎的一个新亚型——老年特应性皮炎。以往认为特应性皮炎多发生于儿童，近年发现老年人也是AD的高发人群。老年特应性皮炎在流行病学、临床表现、发病机制和治疗等方面与儿童和成人特应性皮炎具有显著不同的特点。应高度重视老年特应性皮炎的诊断、鉴别诊断和治疗。     

水陆地黄汤联合盐酸贝那普利对气阴两虚夹瘀型糖尿病肾病氧化应激及临床指标的影响

目的:观察水陆地黄汤对气阴两虚夹瘀型糖尿病肾病氧化应激及临床指标的影响。方法:60例气阴两虚夹瘀型糖尿病肾病患者随机分为对照组与联合组,每组30例,对照组给予盐酸贝那普利片10 mg,1次/d,联合组在对照组基础上加服水陆地黄汤,1剂/d。治疗12周后观察两组氧化应激指标:谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)、丙二醛(MDA)及临床指标:空腹血糖(FPG)、餐后2 h血糖(2 hPG)、糖化血红蛋白(HbA1c)、尿微量白蛋白(mALB)、24 h尿蛋白定量(24 hU-PQ)、肾小球滤过率(eGFR)的变化及临床症状的改善。结果:联合组治疗总有效率为90.0%,与对照组56.7%比较,差异有统计学意义(P<0.05);治疗后联合组MDA较治疗前均降低(P<0.05),SOD、GSH-Px均高于治疗前(P<0.05),与对照组比较,差异有统计学意义(P<0.05);联合组FPG、2 hPG、HbA1c、mALB、24 hU-PQ、eGFR较治疗前均降低(P<0.01)。结论:水陆地黄汤联合盐酸贝那普利可改善气阴两虚夹瘀型糖尿病肾病氧化应激状态,明显缓解临床症状,延缓病程进展。     

Du parricide rêvé à l’infanticide réel,ou l’expertise mentale dans tous ses états

The authors describe at length the case of a 33-year-old woman who shot and killed her 9-year-old daughter and attempted suicide immediately afterwards. The judicial inquiry revealed that this infanticidal mother originally intended to kill her own father, who she accused of having sexually abused her in her own childhood and now her daughter, but that unforeseen circumstances changed the mode of operation. She was the subject of seven more or less contradictory psychiatric experts opinions over a period of more than three years before finally being found criminally irresponsible by the court of assizes. She was suffering from delusional psychotic mental disorders at the time of the homicide-suicide. The authors discuss and criticize the conclusions of the experts opinions and instead recommend a multidisciplinary criminological analysis that takes all the objective ans subjective aspects on the case into account.     

Asistencia biventricular en el manejo de la disfunción ventricular izquierda secundaria a ECMO-VA periférica: a propósito de 2 casos

We report 2 patients with cardiogenic shock that developed severe left ventricular dysfunction due to a non-opening aortic valve while on peripheral VA-ECMO (Veno-Arterial Extracorporeal Membrane Oxygenator). Patients were managed combining a LV (Left Ventricle) mechanical assist device, and central VA – ECMO to support the right ventricle, thus providing full circulatory and respiratory assistance. Patients were able to bridge to cardiac transplantation. We therefore recommend such combination in patients with severe LV dysfunction while on p-ECMO (peripheral ECMO) support.     

Decision-support models for empiric antibiotic selection in Gram-negative bloodstream infections

Objectives

Early empiric antibiotic therapy in patients can improve clinical outcomes in Gram-negative bacteraemia. However, the widespread prevalence of antibiotic-resistant pathogens compromises our ability to provide adequate therapy while minimizing use of broad antibiotics. We sought to determine whether readily available electronic medical record data could be used to develop predictive models for decision support in Gram-negative bacteraemia.

滋肾调冲汤治疗黄体功能不足性月经失调的临床效果分析

目的:探讨滋肾调冲汤治疗黄体功能不足性月经失调的临床价值。方法:对2016年6月-2018年7月本院收治的73例黄体功能不足性月经失调患者的临床资料进行回顾性分析,按照治疗方式的不同分为研究组(37例)与对照组(36例)。对照组患者给予戊酸雌二醇及醋酸甲羟孕酮片进行治疗,研究组患者给予中药滋肾调冲汤,对比两组患者治疗后的疗效观察指标。结果:治疗后,经t检验,两组患者的临床证候积分及各项症状积分明显低于治疗前(P<0.05);研究组患者的临床证候积分及各项症状积分明显低于对照组(P<0.05)。两组患者的高温相评分(Hightemperature Phase Score,HPS)、黄体中期孕酮水平均明显高于治疗前,激素水平低于治疗前(P<0.05);研究组患者的HPS评分、黄体中期孕酮及激素水平均明显高于对照组,激素水平低于对照组(P<0.05)。结论:滋肾调冲汤治疗黄体功能不足性月经失调的疗效显著,可以有效延长黄体期时间,改善临床症状及体征,对促进患者快速康复有积极意义。     

妇科急腹症中的超声临床诊断研究

目的:探讨妇科急腹症中的超声临床诊断研究。方法:纳入40例患者作为研究样本,40例患者均为2017年3月-2019年7月入院接受治疗的妇科急腹症患者,采用随机分组的方式,将40例患者分为两组,每组各20例患者,两组患者接受不同的诊断方式,对照组接受常规诊断,研究组接受超声诊断,对比两组患者诊断准确率。结果:观察并对比两组患者的数据,常规诊断以及超声诊断的临床准确率对比,研究组的准确率高于对照组,两组患者的组间数据对比,表明本次研究具有统计学意义(P<0.05)。结论:妇科急腹症中采用超声诊断,对急腹症类型的诊断效果较为准确,为患者后续的临床治疗提供诊断依据,证实了超声诊断对妇科急腹症在临床诊断上具有重要作用,应提倡将其纳入常规诊断之中。