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61.
Hiroaki Tada Chihiro Masaki Shintaro Tsuka Taro Mukaibo Yusuke Kondo Ryuji Hosokawa 《Journal of prosthodontic research》2018,62(1):89-96
Purpose
The aim of this randomized placebo-controlled clinical study was to investigate the effects of a probiotic tablet containing Lactobacillus reuteri in peri-implantitis patients.Methods
Subjects comprised 30 patients with mild to moderate peri-implantitis. A baseline clinical examination and microbiological assessment were conducted, followed by an antibiotics treatment (azithromycin, 500 mg, once a day for 3 days). Subjects were divided into probiotic and placebo groups. The clinical examination and bacterial sampling were performed 0, 4, 12 and 24 weeks after the intake of probiotics. The clinical examination included probing pocket depth (PPD), bleeding on probing (BOP), the modified plaque index (mPI), and modified bleeding index (mBI). The number of bacteria was assessed using the PCR-invader method. The Wilcoxon rank-sum test and Wilcoxon signed-rank test with Bonferroni corrections were used for data analyses.Results
Although the number of bacteria decreased after the administration of azithromycin in both groups, they increased again thereafter. No significant difference was observed in bacterial numbers between the two groups. Although PPD in the probiotics group was significantly lower at 4 and 24 weeks than at 0 weeks (p < 0.05), a significant decrease did not occur in the placebo group. The mBI score at 24 weeks was significantly lower in the probiotics group than in the placebo group (p < 0.05). No significant difference was observed in BOP or mPI between the two groups.Conclusion
These results suggested that probiotics prevent inflammation by affecting host responses rather than improving microbial flora in peri-implant sulci in peri-implantitis patients. 相似文献62.
Nitika Monga Sushma Chaurasia Om Prakash Kharbanda Ritu Duggal Moganty Raja Rajeswari 《Progress in orthodontics》2014,15(1):30
Background
This study provides a vital insight in assessing the clinical and biochemical changes in interleukin (IL)-1β levels in peri-miniscrew crevicular fluid (PMCF) during the course of orthodontic tooth movement.Methods
The study comprised the analysis of IL-1β in peri-miniscrew crevicular fluid obtained from crevices around the miniscrews inserted in 11 patients (eight females and three males, mean age 17.3 ± 4.64 years) with all first premolar extraction and maximum anchorage requirement using miniscrew-supported anchorage. Miniscrews were loaded at 3 weeks after placement by 200-g nitinol closed coil springs of 9-mm length for en masse retraction. Peri-miniscrew crevicular fluid was collected at miniscrew placement (T1), at 3 weeks (T2/baseline) and on loading at 0 (T3) and 1 day (T4), 21 (T5), 72 (T6), 120 (T7), 180 (T8) and 300 (T9) days. IL-1β levels were estimated by enzyme-linked immunosorbent assay (ELISA). Peri-miniscrew tissue was examined for signs of inflammation, and also, miniscrew mobility was assessed with Periotest and handles of two mouth mirrors.Results
IL-1β levels in all miniscrews were significantly higher at T1 and peaked again at T4 showing a bimodal peak. However, there was a gradual and statistically significant decrease in IL-1β till T5, while further changes till the end of the study were statistically not significant.Conclusions
The changing levels of IL-1β levels in PMCF over a duration of 300 days are suggestive of the underlying inflammatory process. IL-1β levels in PMCF show a significant rise during miniscrew insertion and on immediate loading. The trend of gradually reducing IL-1β levels around the miniscrew over the period after loading towards baseline is suggestive of adaptive bone response to stimulus. 相似文献63.
BackgroundThe aim of this preliminary study was to analyze the effectiveness of three different protocols of decontamination on five commercial moderate rough implants.Material and methodsThe types of implants investigated were: Neoporos Drive CM (CM; Neodent®), Drive CM Acqua (ACQ; Neodent®), SLActive (SLA; Straumann®), Osseotite (OT; Biomet 3i®) and Nanotite (NT; Biomet 3i®). Implant surface properties (n = 2/type of implant; control groups) were analyzed by scanning electron microscopy (SEM) images to determine surface roughness parameters (SRP) and energy disperse X-ray spectrometry to determine the chemical composition. Implants were then inoculated with Aggregatibacter actinomycetencomitans in vitro (n = 6/type of implant;experimental groups) and the contaminated areas were determined in SEM images (500x magnifications). Decontamination of implants was performed in duplicate by three protocols: antimicrobial photodynamic therapy (aPDT), EDTA associated with citric acid (EDTA + CA) and 0.12 % chlorhexidine (CHX). The remaining contaminated area (rCtA) was determined in SEM images (500x magnifications). All quantitative analysis through SEM images were analyzed in ImageJ® software for two-dimensional parameters.ResultsNo significant differences were found in SRP among implants (control group), except for Rv (lowest valley) between SLA vs. OT (p=0.0031; Kruskal Wallis post hoc Dunn). NT implants showed highest contaminated area vs. ACQ implants (68.19 % ± 8.63 % and 57.32 % ± 5.38 %, respectively; p = 0.0016, Tukey's test). SRP after decontamination showed statistical difference for Ra (arithmetical mean deviation) for all decontamination groups when compared to control (p < 0.05; ANOVA with post-hoc Tukey's multiple comparisons test), only CM implants showed statistical difference when compared decontamination protocols to control with highest modification of SRP for EDTA + AC group. For decontamination analysis, for applicability of different protocols in the same type of implant, only SLA showed statistical significant difference for aPDT vs. EDTA + CA (p = 0.0114; ANOVA with post-hoc Tukey's multiple comparisons test) with lowest rCTA for aPDT, however for ACQ implants the aPDT showed lowest rCTA with no statistical difference (p > 0.05; ANOVA with post-hoc Tukey's multiple comparisons test). No statistical difference was observed between the decontamination protocols at other implant types.ConclusionIt can be suggested that the chemical-physical characteristics of dental implants can be effected by the process of contamination and decontamination by aPDT and chemical agents. 相似文献
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目的: 探讨糖尿病患者牙种植术后发生种植体周围炎的危险因素,并建立相关列线图预测模型。方法: 回顾性分析2016年1月—2018年12月行牙种植修复治疗的257例糖尿病患者的临床资料,采用整群随机抽样法将数据分为训练集（n=153）和验证集（n=104）。分别使用单因素和Logistic回归分析,确定糖尿病患者发生种植体周围炎的独立危险因素;同时建立相关列线图预测模型,采用Bootstrap 法对模型进行内部验证,外部验证通过验证集自抽样法完成。采用SPSS 22.0软件包对数据进行统计学分析。结果: 吸烟指数>200支/年（OR=6.364,95%CI：1.943~20.840）、HbA1c>7%（OR=4.680,95%CI：1.497~14.628）、牙周病史（OR=3.779,95%CI：1.359~10.507）、前牙区种植（OR=7.183,95%CI：2.371~21.756）、刷牙频率≤1次/d（OR=4.796,95%CI：1.471~15.637）和未定期洁治（OR=4.994,95%CI：1.745~14.295）是糖尿病患者种植牙术后发生周围炎的独立危险因素（P<0.05）。基于以上6项危险因素建立预测糖尿病患者发生种植体周围炎的列线图模型,校准曲线验证显示,训练集和验证集的预测值与实测值基本一致。ROC曲线验证显示,训练集和验证集的C指数分别为0.867和0.822,说明列线图模型具有良好的预测精准度。结论: 吸烟指数>200支/年、HbA1c>7%、牙周病史、前牙区种植、刷牙频率≤1次/d和未定期洁治是糖尿病患者发生种植体周围炎的独立危险因素,基于以上危险因素建立的列线图模型能够直观、准确预测糖尿病患者发生种植体周围炎的概率。 相似文献
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目的: 探讨Er:YAG激光联合引导骨再生（guided bone regeneration,GBR）治疗种植体周围炎伴骨缺损的临床效果。方法: 选择2017—2019年在嘉定区牙病防治所行种植修复且诊断为种植体周围炎伴骨缺损的26例患者（共34颗种植体）作为研究对象,随机分为实验组和对照组。2组均接受翻瓣、清创和GBR治疗,实验组采用Er:YAG激光处理种植体表面及污染物,对照组采用传统机械法处理。记录和比较2组患者治疗前和治疗后6、12和24个月的探诊深度（probing depth,PD）、探诊出血指数（bleeding on probing,BOP）、菌斑指数（plaque index,PI）、种植体周围边缘骨缺损高度（reduce of marginal bone level,RBL）,采用SPSS 20.0软件包对数据进行统计学分析。结果: 2组患者经不同方法治疗后,PD、BOP、PI和RBL均显著改善;治疗后6、12和24个月后,PD、BOP和PI改善无统计学差异;治疗后12和24个月,实验组RBL改善显著优于对照组。结论: 在种植体周围炎伴骨缺损的GBR治疗中,Er:YAG激光疗法效果优于传统机械法,更有利于新骨再生。 相似文献
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目的探讨两种局部用药治疗种植体周围炎的临床效果。方法选取2011年5月～2013年8月本院收治的口腔科种植体周围炎患者58例,随机分为盐酸米诺环素组29例,甲硝唑凝胶组29例。比较两组患者治疗前和治疗后的第2、4、8周龈沟出血指数（SBI）、菌斑指数（PLI）、牙周袋探诊深度（PD）等指标。结果两组治疗后第2、4、8周,SBI、PLI、PD均明显改善（P〈0．05）,盐酸米诺环素组的改善情况稍优于甲硝唑凝胶组,两组比较,差异无统计学意义（P〉0．05）,但8周后,两种药物的治疗作用持久性均不明显。结论盐酸米诺环素软膏和甲硝唑凝胶局部用药均可以显著改善种植体周围炎的临床状况,药效持久,使用方便,值得临床推广应用。 相似文献
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目的 ：探讨龈沟液中可溶性细胞间黏附分子1(sICAM-1)、白细胞介素1β(IL-1β)和缺氧诱导因子1α(HIF-1α)水平与义齿种植修复并发种植体周围炎（PI）的关系。方法 ：选择2019年1月—2021年12月奉城医院收治的198例义齿种植修复患者,根据义齿种植修复3个月后是否并发PI将患者分为PI组和非PI组。采用酶联免疫吸附法检测义齿种植修复前龈沟液中sICAM-1、IL-1β和HIF-1α水平。多因素Logistic回归分析并发PI的影响因素,ROC曲线分析龈沟液中sICAM-1、IL-1β和HIF-1α水平对义齿种植修复并发PI的预测价值。采用SPSS 28.0软件包对数据进行统计学处理。结果：义齿种植修复后3个月,198例患者PI发生率为17.68%(35/198)。PI组龈沟液中sICAM-1、IL-1β和HIF-1α水平显著高于非PI组（P<0.05）。多因素Logistic回归分析显示,sICAM-1(OR=1.135,95%CI:1.066～1.208)、IL-1β(OR=1.106,95%CI:1.054～1.161)和HIF-1α(OR=1.008,... 相似文献
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《Dental materials》2021,37(10):1553-1560
ObjectiveThe presence of metallic species around failed implants raises concerns about the stability of titanium alloy (Ti-6Al-4V). Graphene nanocoating on titanium alloy (GN) has promising anti-corrosion properties, but its long-term protective potential and structural stability remains unknown. The objective was to determine GN’s anti-corrosion potential and stability over time.MethodsGN and uncoated titanium alloy (Control) were challenged with a highly acidic fluorinated corrosive medium (pH 2.0) for up to 240 days. The samples were periodically tested using potentiodynamic polarization curves, electrochemical impedance spectroscopy and inductively coupled plasma-atomic emission spectroscopy (elemental release). The integrity of samples was determined using Raman spectroscopy, X-ray photoelectron spectroscopy, atomic force microscopy and scanning electron microscopy. Statistical analyses were performed with one-sample t-test, paired t-test and one-way ANOVA with Tukey post-hoc test with a pre-set significance level of 5%.ResultsThere was negligible corrosion and elemental loss on GN. After 240 days of corrosion challenge, the corrosion rate and roughness increased by two and twelve times for the Control whereas remained unchanged for GN. The nanocoating presented remarkably high structural integrity and coverage area (>98%) at all time points tested.SignificanceGraphene nanocoating protects titanium alloy from corrosion and dissolution over a long period while maintaining high structural integrity. This coating has promising potential for persistent protection of titanium and potentially other metallic alloys against corrosion. 相似文献