光动力疗法辅助治疗种植体周围炎疗效的meta分析

目的 系统评价光动力疗法（photodynamic therapy,PDT）联合非手术方法治疗种植体周围炎的疗效。方法 通过计算机检索 The Cochrane Library、PubMed 、Embase、Web of Science、中国知网、万方数据库、维普期刊数据库及中国生物医学文献数据库发表的期刊文献、会议论文和学位论文,收集建库至2018年4月1日公开发表的关于光动力疗法联合非手术治疗对比单纯非手术治疗种植体周围炎的随机对照试验,2名评价员按照文献纳入、排除标准,独立进行文献筛选、数据提取、质量评价并相互核对后,应用Revman 5.3软件进行meta分析。结果 最终有6篇文献符合纳入条件。Meta分析结果显示,PDT联合非手术治疗和单纯非手术治疗相比,3个月后2组附着水平的差异无统计学意义 [WMD=-1.13,95%CI（-3.51,1.25）,P=0.35];3个月后2组的种植体周探诊深度及6个月后2组之间探诊出血指数的差异有统计学意义,分别为[WMD=-0.81,95%CI（-1.52,-0.11）,P=0.02]和[WMD=-5.15, 95%CI（-6.29,-4.01）,P<0.00001]。结论 在种植体周围炎的治疗中,PDT联合非手术治疗相比单纯非手术治疗,可对种植体周探诊深度及探诊出血有更为明显的改善,但两者对附着水平改善效果差别不大。     

Er：YAG激光应用于种植体周围炎治疗的临床效果评估

目的：探讨Er：YAG激光( erbium-doped： yttrium aluminium garnet)与机械刮治治疗种植体周围炎的有效性。方法22例种植体周围炎患者,按照单盲随机分组对照原则将种植体分成2组,试验组采用Er：YAG激光照射,激光能量设定为100 mJ/脉冲、频率10 Hz;对照组采用塑料刮治器和0.2%洗必泰抗菌治疗。在基线、3个月和6个月时进行临床牙周指标的检查测定,包括菌斑指数、出血指数、临床附着水平和探诊深度。结果基线时试验组和对照组间各项临床牙周指标的差异无统计学意义(P>0.05)。治疗后3个月(P<0.01)和6个月(P<0.05),试验组出血指数、菌斑指数和对照组比较差异具有统计学意义;2组探诊深度在治疗后3个月和6个月均有降低,且2组探诊深度的差异均有统计学意义(P<0.05);然而2组临床附着水平差异无统计学意义(P>0.05)。结论 Er：YAG激光治疗后能显著改善种植体周围炎炎症水平,控制种植体周围炎的有效性优于机械刮治治疗。     

康复新液对种植体周围炎疗效的观察

目的 观察康复新液对种植体周围炎的治疗效果。方法 选择种植完成1年以上的患有种植体周围炎的60名患者的60个种植体,经过基础治疗（龈上、龈下洁治,牙周双氧水冲洗）后随机分为3组,分别为A组（康复新液+明胶海绵组：康复新液浸润明胶海绵置入牙周袋内,每周一次）、B组（康复新液组：康复新液冲洗,每周一次）和C组（对照组：生理盐水冲洗组,每周一次）,1个月后,检查各组治疗前后的牙周探诊深度（PD）、牙龈出血指数（SBI）和菌斑指数（PLI）,比较各组的疗效。结果 各组基线时PD、SBI和PLI值之间没有差异（P>0.05）。经过1个月的相应治疗后,PD、SBI和PLI值均有明显改变,与基线时的差异有统计学意义（t>t_0.01,P<0.01）,说明治疗有效;各试验组间两两比较：PD、SBI值,A组与B组,B组与C组间差异没有显著性意义（P>0.05）,但A组与C组比较,差异有统计学意义（P<0.05）。PLI值A、B、C 3组间差异没有统计学意义（P>0.05）。结论 康复新液对种植体周围炎的治疗有一定疗效,但其作用效果和其用药方法有关。     

Effect of UV-photofunctionalization on oral bacterial attachment and biofilm formation to titanium implant material

Bacterial biofilm infections remain prevalent reasons for implant failure. Dental implant placement occurs in the oral environment, which harbors a plethora of biofilm-forming bacteria. Due to its trans-mucosal placement, part of the implant structure is exposed to oral cavity and there is no effective measure to prevent bacterial attachment to implant materials. Here, we demonstrated that UV treatment of titanium immediately prior to use (photofunctionalization) affects the ability of human polymicrobial oral biofilm communities to colonize in the presence of salivary and blood components. UV-treatment of machined titanium transformed the surface from hydrophobic to superhydrophilic. UV-treated surfaces exhibited a significant reduction in bacterial attachment as well as subsequent biofilm formation compared to untreated ones, even though overall bacterial viability was not affected. The function of reducing bacterial colonization was maintained on UV-treated titanium that had been stored in a liquid environment before use. Denaturing gradient gel-electrophoresis (DGGE) and DNA sequencing analyses revealed that while bacterial community profiles appeared different between UV-treated and untreated titanium in the initial attachment phase, this difference vanished as biofilm formation progressed. Our findings confirm that UV-photofunctionalization of titanium has a strong potential to improve outcome of implant placement by creating and maintaining antimicrobial surfaces.     

白细胞介素1与种植体周围炎相关性研究进展

白细胞介素1(IL-1)是一种多功能细胞因子,近来研究显示IL-1参与种植体周围组织的炎性反应和免疫应答,在种植体周围骨缺损重建以及种植体周围炎的发生发展中起重要作用,是影响种植修复成败的主要因素之一。现从IL-1介导的免疫应答及其基因多态性两个方面来阐述IL-1与种植体周围炎发生发展的关系。     

Squamous Cell Carcinoma Presenting as Peri-Implantitis: A Case Report

Dental implants have proved to be a useful adjunct in the rehabilitation of oral cancer patients. We describe the case of a 62-year-old woman who presented with a white patch in the oral cavity, diagnosed to be a squamous cell carcinoma. She underwent extensive surgery including microvascular reconstruction, followed by implant rehabilitation. Unfortunately, she suffered from multiple episodes of peri-implantitis and later on went on to develop oral squamous cell carcinoma around two of the dental implants. Here, we highlight the importance of regular follow-up and maintaining a high index of suspicion in high-risk patients.