异丙酚静脉麻醉在食管贲门狭窄扩张治疗中的应用研究

目的　研究应用异丙酚静脉麻醉在食管贲门狭窄扩张治疗中的可行性和安全性。方法　将食管狭窄病人 80例随机分为观察组 (A组 ) 40例和对照组 (B组 ) 40例 ,观察组给予异丙酚静脉麻醉后再行扩张等治疗 ,对照组则不予静脉麻醉而行常规操作 ,比较两组扩张治疗中病人的反应和感受、操作时间及观察组在治疗前、中、后血压、心率和血氧饱和度的变化。结果　观察组病人满意度 95% ,而对照组为 18% (P <0 0 1) ,观察组病人流涎、恶心呕吐和躁动的发生率明显低于对照组 (P <0 0 1) ,观察组平均操作时间相对较短 ,心率、血压 (收缩压和舒张压 )、血氧饱和度治疗前、中、后无明显差别。结论　在食管贲门狭窄扩张治疗中应用异丙酚静脉麻醉是安全有效的 ,且可缩短操作时间 ,减少不良反应 ,提高病人的依从性     

江苏省电焊工尘肺疾病负担的评价研究

目的探讨电焊工尘肺预防的经济效益和社会效益。方法调查住院电焊工尘肺患者的经济损失和伤残状况,使用伤残调整生命年(DALY)全面衡量患者的疾病负担,分析影响伤残调整生命年的有关因素,定量说明预防电焊工尘肺可避免的经济损失和健康寿命损失。结果DALY的主要影响因素为年龄、电焊工尘肺分期、伤残等级、电焊工尘肺并发结核4项因素。68人DALY损失平均为9.37个健康年,年平均直接经济损失为16 695元,年平均总经济损失为57 054元。结论预防电焊工尘肺发病是减少其疾病负担的关键。     

A case report of primary cardiac capillary hemangioma

Background: Hemangioma of the heart, presenting as a primary cardiac tumor is extremely rare. Methods: We present a 20-year-old male with a cardiac tumor which was incidentally discovered during routine clinical examination. Results: Echocardiography showed a large intramyocardial mass attached to the left ventricle, close to the apex. A tumor was shown near the apex of the left ventricle by Cardiac CT. We performed a total resection surgery of the tumor one week after admission and the patient recovered well and discharged from hospital 7 d after surgery. Conclusion: The pathological diagnosis was primary cardiac capillary hemangioma. No tumor recurrence was shown by echocardiography after 20 months follow-up visits.     

Ski: Double roles in cancers

The Ski (Sloan-Kettering Institute) is an evolutionarily conserved protein that plays a dual role as an oncoprotein and tumor suppressor gene in the development of human cancer. The Ski oncogene was first identified as a transforming protein of the avian Sloan-Kettering retrovirus in 1986. Since its discovery, Ski has been identified as a carcinogenic regulator in a variety of malignant tumors. Later, it was reported that Ski regulates the occurrence and development of some cancers by acting as an oncogene. Ski mediates the proliferation, differentiation, metastasis, and invasion of numerous cancer cells through various mechanisms. Several studies have shown that Ski expression is correlated with the clinical characteristics of cancer patients and is a promising biomarker and therapeutic target for cancer. In this review, we summarize the mechanisms and potential clinical implications of Ski in dimorphism, cancer occurrence, and progression in various types of cancer.     

双轨制安全管理模式在消毒供应中心的应用

[目的]探讨双轨制安全管理模式在消毒供应中心的应用效果。[方法]建立消毒供应中心质量安全管理与行政安全管理的双轨制安全管理模式,通过建立一套实用、可行、规范的操作流程和规章制度,健全安全管理网络,重视要素控制、环节控制、终末控制,达到安全质量管理的持续改进。[结果]双轨制安全管理模式的运用,强化了工作人员的责任心,减少了差错事故的发生率,延长了设备的使用寿命,保障了工作人员的职业安全。[结论]双轨制安全管理模式能有效提高消毒供应中心安全管理综合水平。     

3种方法预防微量注射泵使用中回血的效果观察

作为一种双赢的新型仪器,微量注射泵在临床工作中发挥着很好的作用,既保证了医疗质量使治疗计划能及时准确的实施,又能最大限度减少护理人员的劳动强度.但随着微量注射泵的广泛使用,越来越多的医护人员发现,当输注速度慢、穿刺部位高于泵体时常出现静脉回血现象,容易引起针头堵塞而影响治疗.黎华等[1]研究认为,输注速度为3 mL/h时所有病人均出现静脉回血现象.为尽可能减少使用微量注射泵过程中出现的静脉回血现象,现将3种预防方法报道如下.     

七氟醚不同诱导方法在妇科腹腔镜手术中的应用

目的观察七氟醚不同诱导方法在妇科腹腔镜手术中的应用效果。方法择期行妇科腹腔镜手术患者60例,随机分为面罩肺活量吸入法诱导组(A组)与面罩潮气量吸入法诱导组(B组)。记录睫毛反射消失时间、喉罩插入时间、血流动力学指标、喉罩拔除时间、意识恢复时间及不良反应。结果 A组睫毛反射消失时间短于B组(P<0.01);A组喉罩插入时间短于B组(P<0.01);2组拔除喉罩时间、意识恢复时间、不良反应的发生率差异无统计学意义。结论 2种七氟醚吸入诱导方法均可获得良好的喉罩插入条件,面罩肺活量吸入诱导法起效更为迅速。     

护理干预对维持性血液透析患者的影响

目的:探讨护理干预对维持性血液透析患者的影响。方法:将我院2010年3月～2011年9月期间收治的90例维持性血液透析患者随机分成干预组和对照组,每组45例。对照组患者在进行维持性血液透析的同时采用常规护理,而干预组则在此基础上根据患者的实际情况给予阶段性护理干预,并对两组患者治疗后的相关临床考察指标进行比较和分析。结果:与对照组相比,干预组患者干预后的体重增加/干体重比值降低(P<0.05),液体摄入量减少(P<0.05),治疗依从性提高(P<0.05)。结论:护理干预能够增强维持性血液透析患者液体摄入的依从性,对于保证血液透析的正常进行以及提高患者的生存质量具有积极的辅助治疗价值。     

The role of sentinel lymph node status performed in melanoma patients with local recurrence or in transit metastasis

BackgroundSentinel Node Biopsy (SNB) is routinely performed for primary melanoma, but its role in the treatment of Local Recurrence (LR) and In-Transit metastasis (IT) is controversial. This study aims to assess the role of SNB in melanoma patients who developed first loco-regional recurrence.MethodsA series of consecutive melanoma patients who received SNB for a first IT or LR at the National Cancer Institute of Milan, Italy, from 2000 to 2015 were selected from a prospective database. Clinicopathological characteristics were analyzed.ResultsSeventy-two patients met selection criteria. Forty-three patients (59.7%) received SNB for LR and 29 (40.3%) for IT. The average interval between treatment of primitive melanoma and first recurrence diagnosis was 19 months (interquartile range: 6.9–49.0). SN identification rate was 97.2%. SN positivity was detected in 26 (37.1%) patients. The SN-positive ratein melanoma patients who had LR or IT was significantly higher than reported for primary tumours. Of patients with nodal involvement 17 had LR and 9 IT lesions. Disease Free Survival (DFS) was slightly higher in SN negative patients, in the absence of statistically significant differences. Overall Survival (OS) analysis showed similar values in the two groups.ConclusionSince DFS and OS do not show significant differences between SN negative and positive patients, our data do not give clear indications about performing SNB in case of first LR or IT. However, we suggest submitting patients with LR to this procedure to obtain a more accurate staging and eventually candidate these patients to adjuvant treatment.