西红花甙治疗高脂血症31例

为对比中成药西红花甙（暂名心宁片）和丹参片口服对中老年高脂血症的影响。对62例原发性高脂血症患者随机分成二组各31例，以治疗组西红花甙50mg3次／d及对照组丹参片3粒3次／d口服，均以30d为1个疗程，分别于试验前和试验后检查血脂诸项，并按《药物临床研究指导原则》中调整血脂药物研究判定标准结果。治疗组中显效21例，有效8例，总有效率达93．5％，二组显效率有效率比较差异非常显著（P＜0．01），西红花甙不仅在降低TC、TG方面有明显作用，而且对升高HDL2－C，APO－A方面也有一定作用，同时能下调APO－B，是较为理想调脂药物。     

扶正活血清热方对急性放射性肠炎血清中CAT和MDA的影响

目的探讨扶正活血清热方治疗大鼠急性放射性肠炎（ARE）的作用机制。方法将32只受试大鼠随机分为4组（8只/组）,即空白对照组、模型组、地塞米松组、扶正活血清热方组。模型组、地塞米松组和扶正活血清热方组大鼠于成功造模后第2天开始分别用生理盐水、地塞米松和扶正活血清热方灌肠干预5 d（5毫升/只）,于照射后第7天,麻醉后大鼠经采血测定其中过氧化氢酶（CAT）的活性和丙二醛（MDA）的含量。结果空白对照组、地塞米松组和扶正活血清热方组血清中CAT活性明显高于模型组（F=23.79,P〈0.01）。空白对照组、地塞米松组和扶正活血清热方组血清中MDA含量均明显低于模型组（F=36.41,P〈0.01）。结论扶正活血清热方可能通过下调受损组织中脂质过氧化反应程度来治疗放射性肠炎。     

二孩政策下父母亲生育年龄对于儿童发育短期和长期影响因素分析

目的:探讨全面二孩政策下父母人口学特征对于新生儿以及儿童长期身体发育的影响,为提高优生优育质量提供参考依据。方法:于2014年12月—2020年12月采用分层随机抽样方法调查天津市210个新生儿家庭的人口学资料和儿童身体指标,研究人口学特征和儿童发育情况,采取单因素χ2检验和成对t检验方法分析儿童发育的影响因素。结果:在调查的218个家庭中,高龄产妇（>35岁）所占比例大于低龄产妇（47.7% vs.14.1%）,二胎比例也大于一胎比例（82.0% vs.18.0%）。新生儿的身体指标（出生体重、出生28 d增重和出生身长）与产妇的文化程度、分娩医院、胎次以及分娩方式没有明显的相关性（均P>0. 05）,但与父母年龄存在相关性。不同母亲年龄组间出生体重（χ2 =58.91,P<0.01）、出生28 d增重（χ2 =67.34,P<0.01）、出生身长（χ2 =61.32,P<0.01）有差异,不同父亲年龄组间出生体重（χ2 =68.34,P<0.01）、出生28 d增重（χ2 =72.11,P<0.01）、出生身长（χ2 =75.41,P<0.01）有差异。本项目后期追踪调查了210个家庭的儿童生长状况,结果表明父母年龄对于儿童的体重、身长、牙齿和头围发育均具有长期影响（均P<0.01）。结论:在全面二孩政策下,高龄父母显著增多。父母年龄对于新生儿的身体发育存在影响,并且对于儿童的体重、身长、牙齿和头围发育等存在长期作用。     

担当社会责任 促进民营医院持续发展

从提高医疗效果、解决看病贵的问题、播洒关爱等方面介绍了保定脑血管医院担当社会责任,促进医院持续发展的做法和体会,指出履行社会责任,不断满足患者需求,是民营医院可持续发展的动力源泉。“利他”与“利己”表面看是对立的,实际是相辅相成、互为因果的亲密伙伴。立足于“利他”才能实现毫无愧色的“利己”。     

Study on mechanism of Bushen Yugong Granule in treating uterine dysgenesiain treating uterine dysgenesia

Objective: To explore the therapeutic mechanism of Bushen Yugong Granule (BSYGG, a Chinese medicinal preparation) in treating infertility due to uterine dysgenesia.Methods: (1) Clinical study: Serum level of sex hormone and endometrial contents of estradial receptor (ER) and progesterone receptor (PR) in follicle period of 60 patients (the tested group) were measured and compared before and after treatment, and also compared with those of 70 normal women (the control group). (2) Experimental study: Rats were divided into the control group and 3 tested groups fed with different doses of BSYGG. Pathologic examination of pituitary, ovary and uterus of rats after BSYGG treatment were performed, and serum levels of ER, PR measured. Also, an estrogen activity experiment was conducted in some young oophorectomized rats.Results: (1) Clinical study showed the difference of serum sex hormone levels between the tested and control group was insignificant. The percentage of patients in the tested groups with endometrial ER content over ++ was lower than that in the control group (46.9 % vs 72.4 %) significantly (P < 0.05), after treatment, it rose to 65.4 %, and the change was significant, P<0.05. (2) Experimental study showed that the number of follicle, weight of uterus and serum E₂ level increased significantly after BSYGG treatment. The endometrial content of ER in the control group was 29.25±17.03%, while in the tested groups, it was 67.75 ± 24.56% to 83.00 ± 9.87% after treatment, the difference between the two groups was significant (P<0.005).Conclusion: BSYGG has an estrogen-like activity, it could increase the endometrial content of ER, enhance the effect of estrogen on uterus and promote the development of uterus, so as to elevate fertilization rate.     

不同年龄卒中亚急性期患者上肢感觉与运动功能的关系研究

目的 探讨不同年龄卒中亚急性期患者上肢感觉功能与运动功能的关系。 方法 前瞻性选取2020年6-12月于上海市静安区中心医院、上海市第三康复医院、河南大学附属南 石医院连续收治的卒中亚急性期存在单侧上肢功能障碍的患者。记录患者的临床资料,使用Semmes- Weinstein单丝和两点辨别觉测试工具分别评估上肢的触觉和两点辨别觉,Fugl-Meyer感觉量表综合 评估患者上肢和手的触觉、本体感觉,Fugl -Meyer上肢运动功能评定（Fugl -Meyer assessment upper extremity,FMA-UE）和上肢动作研究测试（action research arm test,ARAT）量表评估患者的上肢运动 功能。将患者分为青中年组（18～59岁）和老年组（≥60岁）,比较两组患者双侧上肢感觉功能差异, 分析总体及不同年龄组患者上肢感觉功能与运动功能的相关性。 结果 共纳入117例患者,平均年龄61.1±11.7岁,卒中病程平均40.0（22.0～61.5）d。青中年组患者 49例（41.9%）,老年组患者68例（58.1%）。两组患者健侧上肢Semmes-Weinstein单丝触觉评分和两 点辨别觉差异具有统计学意义（均P＜0.05）。卒中患者上肢Semmes-Weinstein单丝触觉评分与FMA-UE 评分及ARAT评分呈弱正相关（r值分别为0.296和0.297,均P＜0.01）;Fugl -Meyer感觉功能量表评分与 FMA-UE评分及ARAT评分呈正相关（r值分别为0.402和0.397,均P＜0.01）。两组患者的Fugl-Meyer感觉 功能量表评分均与FMA-UE评分及ARAT评分呈正相关（青中年组r值分别为0.416和0.401,老年组r值 分别为0.389和0.371,均P＜0.01）;老年组患者的上肢Semmes-Weinstein单丝触觉评分与FMA-UE评分及 ARAT评分呈正相关（r值分别为0.330和0.365,均P＜0.01）。 结论 卒中亚急性期患者上肢触觉和本体感觉与运动功能呈正相关。年龄对卒中亚急性期患者上 肢触觉与运动功能的相关性可能存在影响。     

心理旋转试验在脑卒中患者运动表象能力评估中的应用

目的 研究脑卒中患者面对不同图案时的反应策略和影响心理旋转试验结果的主要因素。方法 2018年5月至10月,15例脑卒中患者和15例年龄、性别和教育程度匹配的健康受试者接受基于标准软件程序的心理旋转试验,视觉刺激包括手背、手心、汉字和字母4种图案,记录反应时和正确率。采用蒙特利尔认知功能评估量表(MoCA)评定所有受试者,采用Fugl-Meyer评定量表上肢部分(FMA-UE)评定脑卒中患者。结果 在手背、手心和字母测试中,脑卒中患者的正确率低于健康对照(F > 7.027, P < 0.05)。在所有测试中,脑卒中患者的反应时均显著长于健康对照( F > 14.827, P < 0.001);在手背和手心测试中,反应时随旋转角度的主效应非常高度显著( F > 7.747, P < 0.001),0°时最短。所有受试者的MoCA评分与反应时呈负相关( r < -0.375, P < 0.05),脑卒中患者FMA-UE评分与除字母测试之外的反应时呈负相关( r < -0.581, P < 0.05)。 结论 不同的刺激图案可影响心理旋转试验的处理策略和结果。脑卒中患者的运动表象能力较健康人有所减弱,但基本模式相对保留。     

促宫颈成熟药物对延期妊娠孕妇分娩结局及围产儿的影响

目的：探讨促宫颈成熟药物对延期妊娠孕妇分娩结局及围产儿的影响。方法回顾性分析2010年3月至2013年6月我院收治的137例延期妊娠孕妇,其中45例应用普贝生引产（A组）,45例应用米索前列醇引产（B组）,47例应用催产素引产（C组）。比较三组促宫颈成熟效果及分娩结局。结果 A组促宫颈成熟有效率为91.11%,均显著高于B组和C组的71.11%和61.70%,差异有统计学意义（P〈0.05）。A组引产成功38例,成功率为84.44%,自然分娩率为77.78%,均显著高于B组（26例,57.78%,46.675%）和C组（28例,59.57%,29.78%）,差异均有统计学意义（P〈0.05）;但三组间胎儿宫内窘迫和新生儿窒息发生率比较则差异均无统计学意义（P〉0.05）。不良反应方面三组间比较差异亦无统计学意义（P〉0.05）。结论与米索前列醇和催产素比较,普贝生能够起到较好的促宫颈成熟效果,提高引产成功率和自然分娩率,且对孕妇和产儿无不良影响,是较为有效的促宫颈成熟药物。     

Prediction and prevention of hypertension syndrome of pregnancy]

Analysis of mean artery pressure (MAP-2) according to the differentiation of symptom complex of TCM can predict the occurrence of hypertension syndrome of pregnancy (HSP) at patients' first visit to hospital during their middle gestational period (less than 24 pregnant weeks). 424 pregnant women (MAP-2 greater than or equal to 12kPa) were divided into 4 groups and given preventive treatment as follows: (1) The control group, 122 women, no drugs were given; (2) the Theragan group, 102 women; (3) the TCM (A) group, 100 women, those with Liver-Kidney deficiency of Yin or no apparent signs were given Qiju Dihuang Wan, and those with Spleen-Kidney deficiency of Yang were given Shenqiwan; (4) the TCM(B) group, 100 women, were given Salvia miltiorrhiza plus (A) group's drugs. The results of prediction: (1) The occurrence rate of HSP in the MAP-2 less than 12kPa group was 10. 5%; in the MAP-2 greater than or equal to 12kPa group, 49.2%. The difference was significant. (2) The rate of deficiency of Yin in the MAP-2 greater than or equal to 12kPa was significantly higher than in the MAP-2 less than 12kPa. The rate of HSP in the deficiency of Yin was higher than in the nondeficiency of Yin. The rate of HSP increased to 70. 7% in the MAP-2 greater than or equal to 12kPa with deficiency of Yin. The results of prevention: (1) The occurrence rates of HSP in 4 groups were 49.2%, 30.4%, 15% and 14% respectively. (2) There was no side effect for mother and infant after preventive treatment. No eclampsia occurred.