全文获取类型
收费全文 | 78168篇 |
免费 | 3039篇 |
国内免费 | 123篇 |
专业分类
耳鼻咽喉 | 923篇 |
儿科学 | 2599篇 |
妇产科学 | 2190篇 |
基础医学 | 8374篇 |
口腔科学 | 1763篇 |
临床医学 | 9220篇 |
内科学 | 12874篇 |
皮肤病学 | 921篇 |
神经病学 | 8250篇 |
特种医学 | 3402篇 |
外国民族医学 | 2篇 |
外科学 | 13097篇 |
综合类 | 311篇 |
现状与发展 | 1篇 |
一般理论 | 60篇 |
预防医学 | 6479篇 |
眼科学 | 1091篇 |
药学 | 4808篇 |
1篇 | |
中国医学 | 104篇 |
肿瘤学 | 4860篇 |
出版年
2024年 | 15篇 |
2023年 | 1652篇 |
2022年 | 2861篇 |
2021年 | 3514篇 |
2020年 | 3306篇 |
2019年 | 2329篇 |
2018年 | 1960篇 |
2017年 | 2104篇 |
2016年 | 1822篇 |
2015年 | 2279篇 |
2014年 | 4537篇 |
2013年 | 3558篇 |
2012年 | 3866篇 |
2011年 | 3699篇 |
2010年 | 3261篇 |
2009年 | 3092篇 |
2008年 | 3307篇 |
2007年 | 3617篇 |
2006年 | 3269篇 |
2005年 | 3071篇 |
2004年 | 2700篇 |
2003年 | 2602篇 |
2002年 | 2262篇 |
2001年 | 2127篇 |
2000年 | 1959篇 |
1999年 | 1617篇 |
1998年 | 819篇 |
1997年 | 697篇 |
1996年 | 650篇 |
1995年 | 645篇 |
1994年 | 509篇 |
1993年 | 466篇 |
1992年 | 1033篇 |
1991年 | 993篇 |
1990年 | 971篇 |
1989年 | 875篇 |
1988年 | 945篇 |
1987年 | 362篇 |
1986年 | 115篇 |
1985年 | 303篇 |
1984年 | 312篇 |
1983年 | 240篇 |
1982年 | 265篇 |
1981年 | 195篇 |
1980年 | 165篇 |
1979年 | 134篇 |
1978年 | 94篇 |
1977年 | 77篇 |
1976年 | 52篇 |
1975年 | 13篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
2.
3.
4.
5.
《Journal of pharmaceutical sciences》2023,112(8):2212-2222
For supersaturating formulations of BCS-II compounds, which by definition have high intestinal permeability, a closed USP apparatus does not provide the necessary absorptive conditions during dissolution. To address this, an artificial gut simulator (AGS) has been constructed consisting of a 2.5 mL donor compartment in which a hollow fiber-based absorption module is suspended. Drug from donor diffuses across the hollow fiber membrane to be absorbed by the continuously flowing intraluminal receiver fluid. The membrane surface area and intraluminal fluid flow rate are tuned to obtain the physiologically observed absorption rate constant for a weakly basic, poorly water-soluble model compound, ketoconazole (KTZ). Supersaturated solutions of KTZ were generated in the donor in pH 6.5 phosphate buffer by the pH-shift method in the absence (closed system, control) and presence (open system, biorelevant) of an optimally or suboptimally tuned absorption module. Drug concentrations in the donor and intraluminal fluids were determined by in-line UV spectroscopy. The presence of an absorptive sink reduced the supersaturated solution's crystallization propensity, more so in the case of the optimally tuned AGS. This study demonstrates the significance of simulating absorption of drug at a physiological rate during dissolution studies, especially to predict the performance of formulations of BCS-II drugs. 相似文献
6.
《HPB : the official journal of the International Hepato Pancreato Biliary Association》2022,24(8):1252-1260
BackgroundThe clinical importance of postoperative hyperamylasemia (POHA) grade is unknown. Our objectives were to evaluate the association of POHA grade with clinically relevant postoperative pancreatic fistula (CR-POPF) and compare its prognostic utility against postoperative day 1 drain fluid amylase (DFA-1).MethodsPatients who underwent pancreatectomy from January 2019 through March 2020 were identified in the ACS NSQIP pancreatectomy-targeted dataset. POHA grade was assigned using post-operative serum amylase and clinical sequelae. The primary outcome was CR-POPF within 30 days. The association of POHA grade with CR-POPF was assessed using multivariable logistic regression, and c-statistics were used to compare POHA grade versus DFA-1.ResultsPOHA occurred in 520 patients at 98 hospitals, including 261 (50.2%) with grade A, 234 (45.0%) with grade B, and 25 (4.8%) with grade C POHA. CR-POPFs were increased among patients with grade B (66.2%, OR 9.28 [5.84–14.73]) and C (68.0%, OR 10.50 [3.77–29.26]) versus grade A POHA (19.2%). POHA-inclusive models better predicted CR-POPF than those with DFA-1 alone (p < 0.002) and models with both predictors outperformed POHA alone (p = 0.039).ConclusionPOHA grade represents a measure of post-pancreatectomy outcomes that predicts CR-POPF and outperforms DFA-1 but must be aligned with new international definitions. 相似文献
7.
8.
9.