Point injection of Injectio Radici Astragali for Treatment of Post-chemotherapy Adverse Reactions

With injection of Injectio Radici Astragli into the point Zusanli (ST 36), we have obtained quite satisfactory therapeutic results for treating leukopenia and the impairment in immune functions occurred in cancer chemotherapy. A report follows.     

家兔枕后急性炎症对椎动脉血流影响的实验研究

目的:通过观察枕后软组织急性化学性炎症对椎动脉血流的影响,初步探讨枕后炎症对椎动脉血流影响的机理。方法:家兔30只,随机分为炎症组10只,消炎痛组10只,对照组10只。炎症组家兔左枕后注射多聚甲醛溶液;消炎痛组家兔左枕后注射多聚甲醛溶液后,予喂服消炎痛片剂;对照组家兔左枕后注射生理盐水。各组分别在注射前、注射后12h、24h、48h采用彩色多谱勒超声仪检测双侧椎动脉血流,记录搏动指数(PI),血流阻力指数(RI),收缩期最大流速(PSV),局部声像图改变;注射48h后动物处死,切取双侧枕后软组织作病理学检查。结果:①炎症组和消炎痛组、对照组的左侧椎动脉PI、RI、PSV比较:注射后24h、48h有明显差异(P<0.05);炎症组左右侧椎动脉PI、RI、PSV比较:注射后24h开始有明显差异(P<0.05),并注射后炎症组左侧PI、RI、PSV逐渐增高。②病理学检查(光镜观察):炎症组标本可见肌细胞变性和坏死,大量的嗜中性粒细胞浸润。结论:枕后软组织急性化学性炎症可导致椎动脉痉挛,从而影响椎动脉血流的改变。     

周郁鸿教授中医辨证治疗原发性骨髓纤维化症经验

从病因、病机,分期立法,依法辨治,随证施治,遣方用药等方面介绍了周郁鸿教授临床诊治原发性骨髓纤维化症的经验,并附典型病案以验证。     

Spectrum-effect relationships between UPLC fingerprints and bioactivities of crude secondary roots of Aconitum carmichaelii Debeaux (Fuzi) and its three processed products on mitochondrial growth coupled with canonical correlation analysis

Ethnopharmacological relevance: The crude secondary roots of Aconitum carmichaelii Debeaux (Fuzi), together with its processed products, including Yanfuzi, Heishunpian and Paofupian, are commonly applied in clinic using for thousands of years, such as collapse, syncope, rheumatic fever, painful joints and various tumors.Aim of the study: To explore the different effects of Fuzi and its processed products on energy metabolism, with mitochondria as the model with the aim of guiding the clinical use of Fuzi and its products. fingerprints of Fuzi, Yanfuzi, Heishunpian and Paofupian were established by Ultra-high Performance Liquid Chromatography (UPLC) and effects of Fuzi and its processed products on rat’s liver׳s mitochondrial metabolism were studied by microcalorimetry. Spectrum-effect relationships between UPLC fingerprints and energy metabolism of mitochondria were investigated using canonical correlation analysis (CCA).Results: Because of their inherent differences in chemical compositions, the main activities of energy metabolism of mitochondria were different among Fuzi and its processed products. The potential bioactivity sequence of the tested products was Fuzi>Heishunpian>Paofupian>Yanfuzi. Results of CCA showed that compounds mesaconitine, benzoylaconitine, and benzoylhypacoitine might be the principal active components.Conclusion: Altogether, this work provides a general model of combination of UPLC and microcalorimetry to study the spectrum-effect relationships of Fuzi and its processed products which can offer some references for detecting principal components of traditional Chinese medicine on bioactivity to mitochondrial growth.     

临床护士认知情绪调节对应对方式及心理健康状况的影响

目的探讨临床护士认知情绪调节现状及与应对方式及心理健康状况的关系。方法随机抽取临床护士352人,采用认知情绪调节策略问卷中文版（CERQ—C）、应对方法问卷（CSQ）和症状自评量表（SCL-90）对临床护士进行评价,对比临床护士和常模及护龄〈5年（A组）和护龄≥5年（B组）CERQ—C评分,分析CERQ—C与CSQ、SCL-90的关系。结果临床护士躯体化、强迫、焦虑、抑郁、敌对、人际关系敏感评分高于常模（P〈0．05）。A、B组和常模认知情绪调节评分差异均有统计学意义（P〈0．05）,A组适应性认知情绪调节评分均低于B组,而不适应性认知情绪调节评分均高于B组（P〈0．05）。CERQ—C因子与解决问题、合理化、退避、自责、求助存在相关性（P〈0．05）。CERQ—C因子与躯体化、强迫、焦虑、抑郁、敌对、恐怖、人际关系敏感、偏执存在相关性（P〈0．05）。结论临床护士整体认知情绪调节以正向调节为主,低年资护士在面对负性事件时常表现为责难自己,高年资护士认知情绪调节能力较好．而心理健康状态较差,临床护士认知情绪调节对应对方式和心理健康均有显著影响。     

红曲对去卵巢大鼠BMP-2表达及成骨细胞增殖影响的实验研究

目的:研究红曲对去卵巢大鼠BMP-2表达及成骨细胞增殖的影响.方法:取12周龄的雌性Wistar大鼠40只,其中30只打开腹腔去除双侧卵巢,逐层缝合,另10只予以单纯打开腹腔不切除卵巢.将大鼠分为A组(模型组)、B组(治疗组)、C组(阳性对照组)、D组(假手术组),饲养12周后,分别予以生理盐水、红曲水提液、α-D3水溶液及生理盐水灌胃.灌胃12周后,活杀各组动物,取右胫骨上端做病理切片,通过HE染色对成骨细胞等进行观察比较、BMP-2免疫组化染色观察.结果:经过12周的红曲水提液灌胃治疗,成骨细胞数量明显增加,而且通过免疫组化染色发现有BMP-2的棕色深染,阳性细胞比例明显高于模型组.结论:红曲可促进成骨细胞增殖、分化,推测其治疗骨质疏松症的机制可能是通过提高BMP-2的表达来实现的.     

不同喹诺酮类抗菌药在治疗下呼吸道感染中的药物经济学评价

目的评价加替沙星与左氧氟沙星在治疗下呼吸道感染中的临床疗效和药物经济学效果。方法选择156例下呼吸道感染病例,随机分成2组,分别给予加替沙星与左氧氟沙星治疗,观察疗效并运用药物经济学方法进行分析。结果2组治疗方案的有效率分别为93.60%和91.00%,而左氧氟沙星组的成本效果比优于加替沙星组。结论药物经济学评价结果为左氧氟沙星组的成本效果比优于加替沙星组。     

八宝丹配合介入治疗热毒血瘀型原发性肝癌的临床观察

目的:初步观察八宝丹辅助治疗热毒血瘀原发性肝癌的临床疗效。方法:入选病人随机进入临床观察,一组单纯介入治疗;一组患者在介入基础上口服八宝丹,2粒/次,3次/日连续服用8周为1个周期。介入用药统一为5-FUDR1.0 DDP 60~80mg E-ADM60~80mg 碘油5~10mL,1次/4周共2次。观察八宝丹对患者近期中医证候、客观疗效及毒副反应的影响和1年生存率。结果:两组患者治疗后肿瘤大小、甲胎蛋白浓度比治疗前都有很大程度的缩小或降低。八宝丹联合介入治疗组中医证候的改善明显优于单纯介入治疗组,二者证候稳定改善率分别为85%、55%;单纯介入组患者出现腹痛、呕吐、或体温超过38℃的并发症情况多于八宝丹联合介入治疗组患者。两组比较差别显著P<0.05。单纯介入组患者肝功能损害也明显多于八宝丹联合介入组患者。单纯介入组患者1年生存率48.3%,显著低于八宝丹联合介入组患者61.8%,P<0.05。结论:八宝丹在改善热毒血瘀肝癌患者中医证候,减少、降低介入治疗并发症,延长生存时间有很好的治疗作用;值得进一步研究其在临床治疗肝癌的有效性。     

Effect of composite salviae dropping pill on endothelin gene expression in circulating endothelial cells of patients with coronary heart disease

ＳｉｎｃｅＹａｎａｇｉｓａｗａｅｔａｌ．ｉｓｏｌａｔｅｄａｎｄｐｕｒｉｆｉｅｄｅｎ ｄｏｔｈｅｌｉｎ（ＥＴ）ｆｒｏｍｅｎｄｏｔｈｅｌｉｏｃｙｔｅ,（1） ｉｔｓｂｉｏｌｏｇｉｃａｌｓｉｇｎｉｆｉｃａｎｃｅａｎｄｅｘｐｒｅｓｓｉｏｎｒｅｇｕｌａｔｉｏｎｈａｓｒａｉｓｅｄｍｏｒｅａｎｄｍｏｒｅａｔｔｅｎｔｉｏｎ．ＴｈｅｒｅａｒｅａｂｕｎｄａｎｔＥＴｒｅｃｅｐｔｏｒｓｉｎｔｈｅｃｏｒｏｎａｒｙａｒｔｅｒｉａｌｓｍｏｏｔｈｍｕｓｃｌｅａｎｄＥＴ 1ｉｓｔｈｅｓｔｒｏｎｇｅｓｔｖａｓｏｃｏｎｓｔｒｉｃｔｏｒｋ…