荜澄茄的性状及显微鉴别研究

目的:对中药荜澄茄的性状、微性状及显微鉴别特征进行系统研究,为《中华人民共和国药典》(2025年版)的制定提供科学依据.方法:采用性状鉴别法、微性状鉴别法、正常光与偏振光对比显微观察法,借助实时景深扩展成像技术及大图影像拼接技术获取全息彩色显微影像数据,对荜澄茄药材进行系统的性状及显微鉴别研究.结果:微性状鉴别方面,获...     

基于实时景深扩展-大图影像拼接与偏振光显微鉴别技术的柴胡及其4种混淆品的生药学研究

目的 基于实时景深扩展-大图影像拼接与偏振光显微鉴别技术,对柴胡2个基原品种柴胡Bupleurumchinense或狭叶柴胡B.scorzonerifolium及4种市场常见混淆品（竹叶柴胡B.marginatum、藏柴胡B.marginatumvar.stenophyllum、锥叶柴胡B. bicaule、大叶柴胡B. longiradiatum）的性状、微性状及显微鉴别特征进行系统的对比研究,为柴胡的鉴别及质量控制提供科学依据。方法 性状鉴别研究采用性状及微性状鉴别法,显微鉴别研究采用普通光明场与偏振光暗场对比观察法,结合实时景深扩展成像、大图影像拼接技术,拍摄获取药材组织横切面全息彩色影像图。结果 获取了柴胡及其混淆品的性状及微性状影像数据,首次获取了该类药材横切面显微鉴别普通光及偏振光全息彩色影像数据。对柴胡2个基原品种及其4种混淆品进行了系统的生药学研究。与《中国药典》2020年版相比,性状鉴别补充研究了精细微性状鉴别特征,对柴胡药材根或根茎的上、中、下部位横切面进行对比观察,确定了柴胡药材根或根茎上部横切面组织构造最具特征性,为最佳的横切面显微研究部位。结论 可以综合应用性...     

Herbal medicine (Gan Mai Da Zao decoction) for depression: A systematic review and meta-analysis of randomized controlled trials

The objective of this review was to analyze the trial data on the efficacy and safety of Gan Mai Da Zao (GMDZ) decoction for depression. PubMed, the Cochrane Library, and EMBASE, AMED, Korea Med, DBPIA, OASIS, RISS, KISS, CNKI, Wan Fang Database, and VIP were searched through to May 2014. Randomized controlled trials (RCTs) testing GMDZ decoction for any type of depression were considered. All RCTs of GMDZ decoction or modified GMDZ decoction were included. Data were extracted by 2 independent reviewers. Meta-analysis was used for the pooled data. A total of 298 potentially relevant studies were identified, and 13 RCTs met our inclusion criteria. All of the included RCTs had a high risk of bias across their domains. Three RCTs failed to show favorable effects of GMDZ decoction on response rate or HAMD score in major depression. One RCT showed a beneficial effect of GMDZ decoction on response rate in post-surgical depression, while another failed to do so. Two studies showed favorable effects on response rate in post-stroke depression, while another two failed to do so. A meta-analysis, however, showed that GMDZ decoction produced better response rates than anti-depressants in post-stroke depression (RR: 1.17, I² = 15%). One trial failed to show any beneficial effects of GMDZ decoction on response rate or HAMD score in depression in an elderly sample. Two trials tested GMDZ decoction in combination with anti-depressants but failed to show effects on response rate in major depression, while another did show beneficial effects on response rate in post-stroke depression. In summary, our systematic review and meta-analysis failed to provide evidence of the superiority of GMDZ decoction over anti-depressant therapies for major depression, post-surgical depression, or depression in the elderly, although there was evidence of an effect in post-stroke depression. The quality of evidence for this finding was low, however, because of a high risk of bias.     

蜜紫菀水分快速测定方法研究

目的 采用近红外光谱（NIR）技术结合化学计量学构建快速、无损测定蜜紫菀水分的方法,实现其验收及贮藏养护过程中水分的快速、无损测定。方法 采集蜜紫菀的NIR,进行主成分分析和聚类分析,建立蜜紫菀的NIR无监督模型,以验证NIR的灵敏度;以《中华人民共和国药典》2020年版所测得的水分为真实值,NIR经预处理,建立蜜紫菀水分的偏最小二乘法（PLS）模型。结果 NIR无监督模型可对23批蜜紫菀进行有效辨识,所得结果准确可靠;建立的蜜紫菀水分的PLS模型r为0.856 6、校正均方根误差为0.357 4、交叉验证均方根误差为0.427 6、平均相对误差为3.92%、平均回收率为98.9%,表明模型具有较好的预测性。结论 采用NIR可快速测定蜜紫菀中的水分。