中医药文献语义标注系统研究与开发

目的研究和开发支持中医和现代生物医学本体和术语集的语义标注系统。方法以MedPortal本体库和中医临床术语集等为术语资源库,设计语义标注系统工作流程和功能框架,并开发Web应用系统。结果构建了一个基于Web的中医药文献语义标注系统,支持语料库管理与维护、术语词典管理、语义标注和语义检索等功能,既可以为基于机器学习的信息抽取算法研究提供训练集,又能实现语义层面的多来源数据集成与知识融合。结论该中医药文献语义标注系统设计方案已经过实际项目验证,可为其他同类系统研发提供参考。     

Acupoint stimulation for long COVID: A promising intervention: 穴位刺激治疗长新冠:一种有前景的干预措施

“Long COVID” is a sustained symptom following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). According to recent statistics, at least 65 million people have long COVID, which poses a long-term threat to human health. The pathogenic mechanisms of coronavirus disease 2019 (COVID-19) are complex and affect multiple organs and systems. Common symptoms include palpitations, breathing difficulties, attention and memory deficits, fatigue, anxiety, and depression. It is difficult to achieve satisfactory treatment effect with a single intervention. Currently, treatment strategies for long COVID are still in the exploratory stage, and there is an urgent need to find appropriate and effective methods for long COVID treatment. Traditional Chinese medicine is effective in treating the various phases of COVID-19. Previous studies have shown that acupoint stimulation therapy is effective in improving palpitations, dyspnea, cognitive impairment, anxiety, depression, and other symptoms in patients. According to previous studies, acupoint stimulation may improve various symptoms related to long COVID. This paper discusses the potential application value of acupoint stimulation in the treatment of long COVID-related symptoms, based on the common sequelae of various systems involved in long COVID, and the effect of acupoint stimulation in the treatment of similar symptoms and diseases in recent years.     

基于文献挖掘及复杂网络探讨寻常性痤疮常见中医证型及核心用药规律＊

目的 运用文献挖掘及复杂网络方法探讨中医治疗寻常性痤疮常见证型及核心用药规律。方法 收集中国期刊全文数据库（China National Knowledge Infrastructure，CNKI）、维普中文科技期刊全文数据库（VIP Database，VIP）、万方数据库（WanFang）、中国生物医学文献数据库（Sinomed）中近15年已公开发表的中医治疗寻常性痤疮核心期刊，对其进行医案提取及规范化后，运用复杂网络方法进行分析。结果 共纳入文献178篇，医案数据195条，涉及中药184味，药性多以寒、微寒为主，药物归经归肺经最多，其次肝经、胃经、心经，药物功效多以清热解毒、清热燥湿、清热凉血为主，常见中医证型及对应核心加减处方4个。结论 系统总结了寻常性痤疮近年发病的主流证型、核心处方及用药规律，为之后的临床辨证用药提供参考及借鉴。     

A Case Series of Olfactory Dysfunction in Imported COVID-19 Patients: A 12-Month Follow-Up Study

Objective The scientific community knows little about the long-term influence of coronavirus disease2019(COVID-19) on olfactory dysfunction(OD). With the COVID-19 pandemic ongoing worldwide, the risk of imported cases remains high. In China, it is necessary to understand OD in imported cases.Methods A prospective follow-up design was adopted. A total of 11 self-reported patients with COVID-19 and OD from Xi’an No. 8 Hospital were followed between August 19, 2021, and December 12, 2021.Demographi...     

3- to 24-month Follow-up on COVID-19 with Pulmonary Tuberculosis Survivors after Discharge: Results from a Prospective,Multicenter Study

ObjectiveCoronavirus disease 2019 (COVID-19) and tuberculosis (TB) are major public health and social issues worldwide. The long-term follow-up of COVID-19 with pulmonary TB (PTB) survivors after discharge is unclear. This study aimed to comprehensively describe clinical outcomes, including sequela and recurrence at 3, 12, and 24 months after discharge, among COVID-19 with PTB survivors.MethodsFrom January 22, 2020 to May 6, 2022, with a follow-up by August 26, 2022, a prospective, multicenter follow-up study was conducted on COVID-19 with PTB survivors after discharge in 13 hospitals from four provinces in China. Clinical outcomes, including sequela, recurrence of COVID-19, and PTB survivors, were collected via telephone and face-to-face interviews at 3, 12, and 24 months after discharge.ResultsThirty-two COVID-19 with PTB survivors were included. The median age was 52 (45, 59) years, and 23 (71.9%) were men. Among them, nearly two-thirds (62.5%) of the survivors were moderate, three (9.4%) were severe, and more than half (59.4%) had at least one comorbidity (PTB excluded). The proportion of COVID-19 survivors with at least one sequela symptom decreased from 40.6% at 3 months to 15.8% at 24 months, with anxiety having a higher proportion over a follow-up. Cough and amnesia recovered at the 12-month follow-up, while anxiety, fatigue, and trouble sleeping remained after 24 months. Additionally, one (3.1%) case presented two recurrences of PTB and no re-positive COVID-19 during the follow-up period.ConclusionThe proportion of long symptoms in COVID-19 with PTB survivors decreased over time, while nearly one in six still experience persistent symptoms with a higher proportion of anxiety. The recurrence of PTB and the psychological support of COVID-19 with PTB after discharge require more attention.     

Higenamine as a Potential Pharmacologic Stress Agent in the Detection of Coronary Artery Disease

Myocardial perfusion imaging (MPI) is valuable for the diagnosis, prognosis, and management of coronary artery disease (CAD). The most commonly used pharmacologic stress agents at present are vasodilators and adrenergic agents. However, these agents have contraindications and may cause adverse effects in some patients. Thus, other stress agents feasible for more patients are required. Higenamine (HG) is a β-adrenergic receptor agonist currently approved for clinical trials as a stress agent for myocardial infarction. It also has a promising value in MPI for the detection of CAD in preclinical and clinical studies. This review summarizes the application of HG on MPI, including its mechanism of action, stress protocol, efficacy, and safety.     

饮品对北京市社区中老年人群骨质疏松影响的调查研究

目的 探讨饮品摄入对北京市社区中老年人群骨质疏松的影响。方法 于2017年11月至2018年7月,采用现场问卷调查的形式共筛查北京市朝阳区、丰台区10个社区中老年人1 642例,问卷内容包括受试者的基本信息和饮品饮用习惯（奶制品、豆浆、红茶、绿茶、咖啡及碳酸饮料）等。结合骨密度检测结果,对比分析骨量正常与骨质疏松人群的一般特征、饮品摄入情况,通过Logistic回归方法分析被调查人群骨量疏松可能的影响因素。结果 共计1 540例符合研究方案,其中骨质疏松人群521例,骨量正常人群305例,男性208例,女性618例,平均年龄为（63.0±7.2）岁。两类人群在性别、年龄、体质指数、是否绝经、绝经年限等方面差异均有统计学意义（P<0.01）。经χ2检验,骨质疏松人群经常饮用红茶与绿茶的比例低于骨量正常人群,差异有统计学意义（P<0.01～0.05）。经Logistic回归分析,全人群中经常饮用奶制品可能是预防骨质疏松的保护因素（β=?0.44,OR=0.64,P=0.017）,女性人群中经常饮用咖啡可能是预防骨质疏松的保护因素（β=?1.46,OR=0.23,P=0.032）。结论 北京市社区中老年骨质疏松的发生除受到性别、年龄、 体质指数、绝经年限等因素影响之外,还与居民饮品摄入习惯密切相关,绝经后女性是骨质疏松防治的重点人群。     

《黄帝内经》中足三里穴的定位及主治功用

本文系统梳理了《黄帝内经》中涉及足三里穴的有关条文,依据经文原旨,参考注家有关注释,从腧穴名称、归经定位、取穴方法、针刺方法、主治病证等方面,对足三里穴主治功用、主治特点进行考证.     

我国中医计算机辅助诊断研究热点与趋势的知识图谱分析

目的 分析我国近40年中医计算机辅助诊断研究的相关文献,探索该领域发展现状、研究热点及前沿动态,为后期研究提供参考和借鉴.方法 检索中国知识资源总库(CNKI)自建库至2020年10月31日发表的中医计算机辅助诊断研究相关文献,运用CiteSpace v.5.7.R2软件对发文量、作者、发文机构、关键词进行分析挖掘,并...     

中医药科学数据的数据质量研究

在国家科技部基础性工作-建设“中医药科学数据管理与共享服务中心”取得成果的基础上,以中国中医科学院中医药信息研究所目前存在的110个中医药数据库260G数据为基础数据源,结合网络和其他来源数据,讨论中医药数据仓库的建设及数据整合。技术上主要从元数据模型入手,研究中医药数据质量评价标准和关键维度评估算法,对构建的数据仓库进行数据质量的评估,从而完成高数据质量的中医药数据仓库。