Scientific connotation of “treating different diseases with the same method” from the perspective of metabolic–immune dysregulation in inflammation-mediated carcinogenesis of digestive organs

Inflammation-mediated carcinogenesis develops in the context of chronic inflammation and is a significant cause of cancer within the digestive system. In the chronic inflammation microenvironment, the metabolic activity of tissue cells undergoes extensive changes, which interfere with the normal function of immune cells. Dysregulation of cell metabolism and immune function has been identified as a key factor contributing to inflammation-mediated carcinogenesis within the major digestive organs, such as the stomach, liver, and colorectum. This metabolic–immune imbalance also corresponds to traditional Chinese medicine (TCM) theories of “yin-yang disharmony” and “disharmony between Ying-nutrients and Wei-defense.” The metabolic–immune imbalance has also been regarded as the key factor supporting “treatment of different diseases with the same method,” in which the same approach is adopted in the treatment of different conditions. In the TCM treatment process, it is necessary to first identify TCM patterns and then apply the corresponding TCM to correct the dysregulated metabolic and immune function, thereby blocking the progression from inflammation to malignancy. Our study findings deepen the TCM understanding of metabolic–immune dysregulation and the relationship between metabolic–immune dysregulation, pattern identification, and treatment method. They also provide new insights for the treatment of inflammation-mediated carcinogenesis in major digestive organs and help us further explore the scientific connotation of the TCM strategy of “treating different diseases with the same method.     

条形码在中药注射剂安全性监测中的应用探索

将条形码引入中药注射剂安全性监测,对于保质保量完成监测任务,节省监测成本均具有重要意义。该文从条形码系统的组成、条形码扫描和数据采集流程、条形码系统设计要点3个方面介绍在中药注射剂安全性监测中应用条形码的经验和教训,以为相似工作之参考。     

基于中医药数据库的中医药治疗肺癌临床文献分析

目的对中国中医药数据库检索系统收录的2000—2009年有关肺癌临床文献进行文献计量学分析,以期给广大医学科研工作者以参考。方法将文献的题名、作者、单位、基金、刊名、主题词等数据导入MicrosoftOfficehccess,对发表时间、来源期刊、发丈机构、基金资助情况等进行统计分析,并采用SPSS13．0软件对关键词进行聚类分析。结果采用“模糊检索”得到文献835篇。我国肺癌临床研究的高生产力地区主要集中在浙江、山东、江苏、广东、河南5地;尚未形成核心作者群,高产作者少;临床用药主要涉及黄芪、党参、人参等;联系比较紧密的学科是病理学、外科学;涉及的治疗仪器是体层摄影术、X线计算机。结论中医药在肺癌临床方面有着广泛的应用,与西医结合发挥其作用价值日趋明显。     

常用中药饮片用量问卷调查报告

在全国不同区域,选取18个省市的21家医院,采用分层抽样和简单随机抽样相结合的方法,收集调查问卷1704份,进行统计分析.通过调研发现,78.4%的专家认为有必要修订药典对饮片用量的规定,中医临床医生认为<中国药典>规定的中药用量普遍偏小,有必要加以部分修订,为制定用量新标准提供了依据.     

基于文本挖掘技术的高血压病中成药与西药用药规律分析

目的:使用文本挖掘技术探索高血压病中成药、西药的用药规律。方法:在中国生物医学文献数据中检索高血压相关文献,利用专有的文本工具进行信息提取,通过反复清洗,去除噪音,分析治疗高血压病的常用中药、中成药、西药及中成药、西药配伍使用情况。结果:治疗高血压病最常用的中药是天麻、钩藤,最常用的中成药是丹参注射液和珍菊降压片,最常用的西药是卡托普利和硝苯地平,最常用的中成药、西药配伍是卡托普利和珍菊降压片、硝苯地平和珍菊降压片。结论:使用文本挖掘技术能够得到符合临床实际的治疗高血压病的常用中药、中成药、西药、中成药与西药配伍,为探索中成药、西药治疗高血压病用药规律提供文献学支持。     

中药复方研发与专利保护协调发展之积极影响分析

中药复方研发成果与日俱增,而成果的专利保护状况却不容乐观.中药复方专利保护与中药新药研发、产业发展、中药国际化等诸多领域息息相关,促成中药复方研发与专利保护的协调发展对于国内乃至国际社会影响深远.     

五味沙棘散对卵清蛋白诱导的过敏性支气管哮喘大鼠的保护作用及机制

目的 探究五味沙棘散对卵清蛋白（ovalbumin,OVA）诱导的过敏性哮喘大鼠的保护作用及机制。方法 SD大鼠随机分为对照组、模型组、地塞米松（0.5 mg/kg）组和五味沙棘散（0.5、2.0 g/kg）组,建立OVA诱导的大鼠早期支气管哮喘模型,苏木素-伊红（HE）和Masson染色观察支气管病理情况及纤维化程度;免疫组化检测支气管间隙连接蛋白43（connexin 43,Cx43）的表达和分布;ELISA检测血清中免疫球蛋白E（immunoglobulin E,IgE）和白细胞介素-13（interleukin-13,IL-13）水平;亚甲基蓝法和WSP-1荧光探针法测定血清中硫化氢（hydrogen sulfide,H₂S）水平。建立CdCl₂诱导的支气管上皮BEAS-2B细胞损伤模型,MTT法检测细胞活性;Hoechest 33342染色法观察细胞核形态变化;MitoSOX染色检测细胞线粒体活性氧（mitochondrial reactive oxygen species,mtROS）水平;Western blotting检测半胱氨酸天冬氨酸蛋白酶-3（cystein-asparate protease-3,Caspase-3）、核因子红细胞系2相关因子（nuclear factor erythroid 2-related factor,Nrf2）和Kelch样ECH关联蛋白1（Kelch like ECH associated protein 1,Keap1）蛋白表达。结果 五味沙棘散能够减少支气管黏膜上皮细胞脱落和黏液分泌（P＜0.001）,降低胶原纤维的沉积和Cx43的表达及分布（P＜0.05、0.01、0.001）,降低血清中IgE、IL-13水平（P＜0.05）,升高血清中H₂S水平（P＜0.05、0.01）。五味沙棘散含药血清呈剂量相关性地抑制CdCl₂诱导的BEAS-2B细胞凋亡及mtROS水平（P＜0.01、0.001）,上调Caspase-3和Nrf2蛋白表达（P＜0.05、0.01）,下调Keap1蛋白表达（P＜0.01）。结论 五味沙棘散对OVA诱导的哮喘大鼠和CdCl₂诱导的支气管上皮细胞凋亡均具有保护作用,其机制可能与调控Nrf2/Keap1信号通路有关。     

Improving the health and treatment success rates of in vitro fertilization patients with traditional Chinese medicine: Need for more robust evidence and innovative approaches

Maximising access to and the success of fertility treatments should be a priority for global reproductive health, as should overall patient well-being. The demand for in vitro fertilization(IVF) and other assisted fertility treatments has increased over the past decade and is likely to further increase in years to come.Nevertheless, there is still considerable unmet demand for infertility support worldwide. Moreover, the high emotional, physical and financial burden experienced by individuals un...     

从瘀论治功能性肛门直肠痛

功能性肛门直肠痛是一种以肛门直肠疼痛、坠胀、便意明显为主要临床表现的肛门直肠疾病,具有病程长、易反复特点,尤其慢性功能性肛门直肠痛患者生活质量下降明显,常合并失眠、抑郁、焦虑等.目前单纯西药治疗效果不佳.中医有一定疗效,但仍有部分患者疗效不佳.本文提出"气滞血瘀"是功能性肛门直肠痛核心病机,"从瘀论治"是其基本治法,并...