Spontaneous regression of stage Ⅲ neuroblastoma: A case report

BACKGROUND Neuroblastoma(NB) is the most common type of extracranial solid tumour in children. The overall prognosis of NB is poor, but at the same time, NB shows significant clinical diversity. NB can demonstrate spontaneous regression or can differentiate into benign ganglioneuroma.CASE SUMMARY This study retrospectively analyzed the clinical data of a patient with spontaneous regression of stage Ⅲ NB who was admitted in May 2015. Studies of the spontaneous regression of NB published from October 1946 to September 2019 were retrieved through Pub Med. The clinical manifestations, diagnosis,treatment, and follow-up results were analysed.CONCLUSION Spontaneous regression of stage Ⅲ NB is rare in the clinic. The report of this case is an important supplement to the study of the spontaneous regression of NB.     

关键业绩指标体系提高护士工作效率的探讨

护理服务质量的提升和护理事业的快速发展离不开护理人员的效率提升.本研究尝试将现代管理方法中的关键业绩指标(KPI)引入护理管理,旨在构建质量和效益均衡发展的新型绩效考核体系,以达到对医疗卫生服务的重点活动及其核心效果进行直接控制和衡量,进而实现医院和员工的可持续发展.     

Ginsenoside Rg1 ameliorates blood–brain barrier disruption and traumatic brain injury via attenuating macrophages derived exosomes miR-21 release

During the traumatic brain injury (TBI), improved expression of circulatory miR-21 serves as a diagnostic feature. Low levels of exosome-miR-21 in the brain can effectively improve neuroinflammation and blood–brain barrier (BBB) permeability, reduce nerve apoptosis, restore neural function and ameliorate TBI. We evaluated the role of macrophage derived exosomes-miR-21 (M-Exos-miR-21) in disrupting BBB, deteriorating TBI, and Rg1 interventions. IL-1β-induced macrophages (IIM)-Exos-miR-21 can activate NF-κB signaling pathway and induce the expressions of MMP-1, -3 and -9 and downregulate the levels of tight junction proteins (TJPs) deteriorating the BBB. Rg1 reduced miR-21-5p content in IIM-Exos (RIIM-Exos). The interaction of NMIIA–HSP90 controlled the release of Exos-miR-21, this interaction was restricted by Rg1. Rg1 could inhibit the Exos-miR-21 release in peripheral blood flow to brain, enhancing TIMP3 protein expression, MMPs proteolysis, and restricting TJPs degradation thus protected the BBB integrity. Conclusively, Rg1 can improve the cerebrovascular endothelial injury and hold the therapeutic potential against TBI disease.     

医疗改革形势下医学专业毕业生就业形势分析与对策

随着高校招生规模的扩大,就业问题已成为社会关注的民生问题。医学专业由于专业性强、岗位有限等原因,就业形势十分严峻。2008年以来国家正积极进行新一轮医疗卫生改革,这将会给医学生的就业局面改善带来新的机遇。该文结合新医改的内容,对如何提高医学生的就业率进行了探讨。     

Meta-analysis of the transforming growth factor-β1 polymorphisms and susceptibility to Alzheimer’s disease

The association between transforming growth factor-β1 (TGF-β1) gene polymorphisms and Alzheimer’s disease (AD) risk has been widely reported, but results were somewhat controversial and underpowered. To derive a more precise estimation of the relationship between TGF-β1 polymorphisms and AD risk, we conducted a meta-analysis of all available case–control studies relating the T869C and/or C-509T polymorphisms of the TGF-β1 gene to the risk of developing AD. Eligible articles were identified by search of databases including Pub Med, Web of Science, the Chinese Biomedical Database (CBM), Chinese National Knowledge Infrastructure (CNKI) and the Wan Fang (Chinese) for the period up to March 2012. Finally, a total of 14 articles were identified, 10 with 1,657 cases and 6,971 controls for T869C polymorphism and 8 with 2,618 cases and 7,473 controls for C-509T polymorphism. The pooled ORs were performed for the allele contrasts, additive genetic model, dominant genetic model and recessive genetic model, respectively. Subgroup analysis was also performed by ethnicity. With respect to T869C and C-509T polymorphism, the combined results showed that there were no significant differences in genotype distribution between AD and control based on all studies. When stratifying for the race, there were also no statistically significant differences in genotype distribution between AD and controls. This meta-analysis did not provide an evidence of confirming association between the T869C and/or C-509T polymorphisms of the TGF-β1 gene and AD.     

伊里扎诺夫技术修复兔胫骨骨缺损成骨机制的研究

目的探讨截骨推移区骨愈合的组织学特点和新骨形成规律。方法取青紫蓝兔24只,建立胫骨大段骨缺损模型,在近干骺端截骨。分别于截骨后第1、2、4、6、8、10周各处死4只兔,在近干骺端的分离区取材进行组织学观察。结果截骨后第1周出现血肿机化,第4周出现膜内成骨和软骨内成骨,第6周推移区大部分被骨性骨痂取代,第8周开始改建。结论推移区存在膜内成骨和软骨内成骨2种方式,以膜内成骨为主。     

Carto 3系统指导下导管消融频发性室性早搏的有效性观察

目的 探讨Carto 3三维电生理导航系统指导消融频发性室性早搏(PVC)的临床疗效,以及射频消融术(RFCA)前后血浆氨基末端B型利钠肽(NT-pro BNP)、心脏结构功能的变化。方法 选取2011年至2013年47例频发室性早搏患者行射频消融治疗的患者为病例组,根据标测系统的不同,分为传统组(n=17)和三维组(n=30)。观察比较两组手术时间、X线曝光时间、放电次数及手术即刻成功率、远期成功率。同时监测所有病例行导管消融前及消融3个月后的NT-pro BNP、左室射血分数(LVEF)及左室舒张末期内径(LVEDd)值,另选取51例健康体检者为对照组。结果 三维组在手术时间、X线曝光时间、消融放电次数上明显优于传统组,且差异有统计学意义(P<0.05)。两组即刻成功率(82.35% vs 93.33%)、远期成功率(76.47% vs 86.67%)相近,差异无统计学意义(P>0.05)。对照组、病例组术前、病例组术后3个月NT-pro BNP浓度、LVEDd以及LVEF值比较,差异均无统计学意义(P>0.05)。结论 较二维影像,在Carto 3三维电生理导航系统下行射频消融治疗频发性室性早搏具有较高的即刻及远期成功率,且安全、有效。     

Exploring the interaction between Salvia miltiorrhiza and α-glucosidase: insights from computational analysis and experimental studies

α-Glucosidase has emerged as an important target for type 2 diabetes mellitus. Salvia miltiorrhiza is a widely used traditional Chinese medicine. The interaction between the chemicals of S. miltiorrhiza and α-glucosidase are still not clear, and need to be deeply investigated. Herein, an integrated approach consisting of computational analysis and experimental studies was employed to illustrate the interactions between S. miltiorrhiza and α-glucosidase. Molecular docking simulations were performed to reveal the proposed binding characteristics of the chemicals identified in S. miltiorrhiza on the basis of the total docking scores and key molecular determinants for binding. The affinities of 13 representative compounds from the medicinal herb to α-glucosidase were predicted and then confirmed by enzyme inhibitory assay in vitro. The obtained results suggested that two compounds including salvianolic acid C and salvianolic acid A in S. miltiorrhiza showed potent α-glucosidase inhibitory activity with IC₅₀ values of 4.31 and 19.29 μM, respectively. The active inhibitor, salvianolic acid C, exerted a mixed-competitive inhibition mode when binding to α-glucosidase. Such findings could be helpful to efficiently discover bioactive molecules from complex natural products, which suggests the usefulness of the integrated approach for this scenario.

An integrated approach was used to explore the interaction between Salvia miltiorrhiza and α-glucosidase.     

非超声乳化小切口白内障术中后囊膜破裂的临床分析

目的：探讨非超声乳化小切口白内障术中晶状体后囊膜破裂的临床原因及处理方法。
　　方法：回顾分析108例121眼非超声乳化小切口白内障人工晶状体植入术,对术中6例6眼后囊破裂患者原因及处理方法进行分析和总结。
　　结果：术中发生晶状体后囊破裂6例6眼(4.96%),其中术中植入后房型人工晶状体2例2眼,术后1 wk行Ⅱ期睫状沟人工晶状体植入2例2眼,前房型人工晶状体植入2例2眼。术后1~3mo门诊复诊,矫正视力<0.1者1例1眼,为黄斑病变眼底;0.3者1例1眼为糖尿病视网膜病变眼底;0.4~0.6者2例2眼;>0.6者2例2眼,均无严重并发症。
　　结论：晶状体后囊破裂为非超声乳化小切口白内障联合人工晶状体植入术中最常见并发症之一,可发生于术中任何步骤。术者提高手术操作技巧,并不断积累经验,可有效地减少后囊破裂的发生率;即使术中出现后囊破裂,及时发现并妥善处理,患者术后仍可获得良好的手术效果。