全文获取类型
收费全文 | 21246篇 |
免费 | 624篇 |
国内免费 | 39篇 |
专业分类
耳鼻咽喉 | 156篇 |
儿科学 | 506篇 |
妇产科学 | 565篇 |
基础医学 | 2963篇 |
口腔科学 | 346篇 |
临床医学 | 1841篇 |
内科学 | 3226篇 |
皮肤病学 | 444篇 |
神经病学 | 1827篇 |
特种医学 | 1272篇 |
外科学 | 2911篇 |
综合类 | 122篇 |
一般理论 | 12篇 |
预防医学 | 1587篇 |
眼科学 | 321篇 |
药学 | 2034篇 |
中国医学 | 95篇 |
肿瘤学 | 1681篇 |
出版年
2023年 | 575篇 |
2022年 | 740篇 |
2021年 | 836篇 |
2020年 | 918篇 |
2019年 | 773篇 |
2018年 | 592篇 |
2017年 | 517篇 |
2016年 | 439篇 |
2015年 | 656篇 |
2014年 | 1047篇 |
2013年 | 1097篇 |
2012年 | 924篇 |
2011年 | 871篇 |
2010年 | 922篇 |
2009年 | 973篇 |
2008年 | 809篇 |
2007年 | 890篇 |
2006年 | 778篇 |
2005年 | 705篇 |
2004年 | 648篇 |
2003年 | 643篇 |
2002年 | 595篇 |
2001年 | 643篇 |
2000年 | 467篇 |
1999年 | 379篇 |
1998年 | 299篇 |
1997年 | 262篇 |
1996年 | 265篇 |
1995年 | 233篇 |
1994年 | 203篇 |
1993年 | 217篇 |
1992年 | 122篇 |
1991年 | 90篇 |
1990年 | 116篇 |
1989年 | 121篇 |
1988年 | 93篇 |
1987年 | 71篇 |
1986年 | 79篇 |
1985年 | 112篇 |
1984年 | 116篇 |
1983年 | 75篇 |
1982年 | 94篇 |
1981年 | 69篇 |
1980年 | 75篇 |
1979年 | 74篇 |
1978年 | 58篇 |
1977年 | 63篇 |
1976年 | 51篇 |
1975年 | 40篇 |
1973年 | 35篇 |
排序方式: 共有10000条查询结果,搜索用时 234 毫秒
51.
《European journal of surgical oncology》2019,45(10):1870-1875
The challenges of conducting surgical oncology trials have resulted to low quantity and poor quality research [1,2]. Considering the definitive role of surgery to offer cure, immediate response to improve surgical research is needed [3]. The European Organization for Research and Treatment of Cancer (EORTC) and the European Society of Surgical Oncology (ESSO) share the vision to achieve excellent surgical research and care for cancer patients. Building on their complimentary expertise, they embarked on a pilot project to map out challenges and initiate a sustainable collaboration to advance cancer surgery research in Europe. This pilot project is EORTC-ESSO 1409 GITCG/ ESSO-01: A Prospective Colorectal Liver Metastasis Database with an Integrated Quality Assurance Program (CLIMB). This article will describe the challenges, milestones and vision of both organizations in setting up this collaboration. 相似文献
52.
BackgroundPhysical exercise, such as walking, is imperative to older adults. However, long-distance walking may increase walking instability which exposes them to some fall risks.ObjectiveTo evaluate the influence of long-distance walking on gait asymmetry and variability of older adults.MethodSixteen physically active older adults were instructed to walk on a treadmill for a total of 60 min. Gait experiments were conducted over-ground at the baseline (before treadmill-walk), after first 30 min (30-min) and second 30 min (60-min) of the walk. In addition to spatiotemporal parameters, median absolute deviation of the joint angular velocity was measured to evaluate gait asymmetry and gait variability.FindingsThere were significant differences in the overall asymmetry index among the three time instances (Partial η2 = 0.77, p < .05), predominantly contributed by the ankle (Partial η2 = 0.31, p < .017). Long-distance walking significantly increased the average and maximum median absolute deviation of the ankle at both sides (W ≥ 0.19, p < .05), and knee at the non-dominant side (W = 0.44, p < .05).Interpretation.At 30-min, the older adults demonstrated a significantly higher asymmetry and variability at the ankle, which implied higher instability. Continue walking for an additional 30 min (60-min) further increased variability of the non-dominant limb at the knee joint. Walking for 30 min or more could significantly reduce walking stability. 相似文献
53.
《Actas urologicas espa?olas》2020,44(5):309-313
Common abuse of anabolic androgenic steroids (AAS) is no longer confined to high performance athletes, as it has spread among the general population. Epidemiological data about the abuse of these substances show that it is a common practice in young populations. Its use is based on the desire to increase muscle mass and strength, as well as improving physical performance. The ease of acquisition of this type of substances has developed a “sophisticated” knowledge of steroid pharmacology based on subjective and anecdotal analysis with no adverse event information, which translates into a public health crisis. Unfortunately, athletes seem to be more influenced by these experiences than by their physician's advice.The abuse of AAS by the athlete and non-athlete population and its adverse events ought to be evaluated in order to improve routine clinical practice on this regard. 相似文献
54.
《The surgeon》2020,18(3):165-177
IntroductionThe liver is the most frequently damaged organ in blunt abdominal trauma. It is widely accepted that hemodynamically stable patients with low-grade liver trauma should be treated with non-operative management, however there is controversy surrounding its safety and efficacy in high-grade trauma. The purpose of this review is to investigate the role of non-operative management in patients with high-grade liver trauma.MethodsPubMed and reference lists of PubMed articles were searched to find studies that examined the efficacy of non-operative management in high-grade liver injury patients, and compare it to operative management. Non-operative management was considered successful if rescue surgery was avoided. Outcomes considered were success, mortality, and complication rates.ResultsThe electronic search revealed 2662 records, 8 of which met the inclusion criteria. All 8 studies contained results suggesting that non-operative management was safe and effective in hemodynamically stable patients with high-grade liver trauma. By combining the outcomes of the different studies, non-operative management had a high success rate of 92.4% (194/210) in high-grade liver trauma patients, which was near the overall 95.0% non-operative management success rate. Non-operative management also had mortality and complication rates of 4.6% (9/194) and 9.7% (7/72) in high-grade injury patients, respectively, compared to operative management's 17.6% (26/148) and 45.5% (5/11).ConclusionNon-operative management of liver trauma is safe and effective in hemodynamically stable patients with high-grade liver injury. It is associated with significantly lower mortality compared with operative management. More studies are required to evaluate complications of non-operative management in high-grade liver injury. 相似文献
55.
Marie Warrer Petersen Tine Sylvest Meyhoff Marie Helleberg Maj-Brit Nørregaard Kjær Anders Granholm Carl Johan Steensen Hjortsø Thomas Steen Jensen Morten Hylander Møller Peter Buhl Hjortrup Mik Wetterslev Gitte Kingo Vesterlund Lene Russell Vibeke Lind Jørgensen Klaus Tjelle Thomas Benfield Charlotte Suppli Ulrik Anne Sofie Andreasen Thomas Mohr Morten H. Bestle Lone Musaeus Poulsen Mette Friberg Hitz Thomas Hildebrandt Lene Surland Knudsen Anders Møller Christoffer Grant Sølling Anne Craveiro Brøchner Bodil Steen Rasmussen Henrik Nielsen Steffen Christensen Thomas Strøm Maria Cronhjort Rebecka Rubenson Wahlin Stephan Jakob Luca Cioccari Balasubramanian Venkatesh Naomi Hammond Vivekanand Jha Sheila Nainan Myatra Christian Gluud Theis Lange Anders Perner 《Acta anaesthesiologica Scandinavica》2020,64(9):1365-1375
Introduction
Severe acute respiratory syndrome coronavirus-2 has caused a pandemic of coronavirus disease (COVID-19) with many patients developing hypoxic respiratory failure. Corticosteroids reduce the time on mechanical ventilation, length of stay in the intensive care unit and potentially also mortality in similar patient populations. However, corticosteroids have undesirable effects, including longer time to viral clearance. Clinical equipoise on the use of corticosteroids for COVID-19 exists.Methods
The COVID STEROID trial is an international, randomised, stratified, blinded clinical trial. We will allocate 1000 adult patients with COVID-19 receiving ≥10 L/min of oxygen or on mechanical ventilation to intravenous hydrocortisone 200 mg daily vs placebo (0.9% saline) for 7 days. The primary outcome is days alive without life support (ie mechanical ventilation, circulatory support, and renal replacement therapy) at day 28. Secondary outcomes are serious adverse reactions at day 14; days alive without life support at day 90; days alive and out of hospital at day 90; all-cause mortality at day 28, day 90, and 1 year; and health-related quality of life at 1 year. We will conduct the statistical analyses according to this protocol, including interim analyses for every 250 patients followed for 28 days. The primary outcome will be compared using the Kryger Jensen and Lange test in the intention to treat population and reported as differences in means and medians with 95% confidence intervals.Discussion
The COVID STEROID trial will provide important evidence to guide the use of corticosteroids in COVID-19 and severe hypoxia.56.
Renaud Snanoudj Nassim Kamar Elisabeth Cassuto Sophie Caillard Marie Metzger Pierre Merville Antoine Thierry Isabelle Jollet Philippe Grimbert Dany Anglicheau Marc Hazzan Gabriel Choukroun Bruno Hurault De Ligny Bénedicte Janbon Vincent Vuiblet Anne Devys Yann Le Meur Michel Delahousse Jean-Luc Taupin 《Kidney international》2019,95(6):1471-1485
57.
《Revue d'épidémiologie et de santé publique》2020,68(6):327-336
BackgroundOur study was aimed at examining disparate exposure to physically demanding working conditions in France, a key objective being to identify the types of employees/jobs requiring high-priority preventive actions.MethodsWe analyzed the data from the 2017 French nationwide cross-sectional survey (SUMER) on occupational hazards to which French employees in various sectors were subjected. The prevalence of several types of physically demanding working conditions (lifting of heavy loads, awkward body postures, vibrations, noise, and extreme temperatures) was explored. Potential associations of individual and job characteristics with these factors of hardship at work were studied by multivariate logistic regression.ResultsIn total, 48% of employees were exposed to at least one physically demanding working condition and 24.8% were exposed to multiple constraints. While managers and intellectual professionals were exposed relatively infrequently to physical constraints, blue-collar workers experienced the highest frequency of exposure. On the one hand, the role of company size depended on the factor of hardship at work considered; on the other hand, employees in large-scale companies were generally less exposed. As expected, employees in the construction industry were the most exposed to physical constraints; that said, our results also show that some activities in the services sector (e.g., personal care, administrative and support services) were quite significantly affected by a wide array of physically demanding working conditions.ConclusionNotwithstanding the establishment in France of Plans de Sant233; au travail (preventive workplace health and safety plans), occupational risks were found to be high, and above all, they were unevenly distributed among the various socio-professional categories, and strongly contributed to social inequalities in health. Our results identify the types of publics to be designated as high-priority targets for preventive measures aimed at reducing the adverse impacts of physically demanding working conditions and the incidence of associated musculoskeletal disorders. 相似文献
58.
《L'évolution Psychiatrique》2019,84(4):539-548
ObjectivesThe authors set out to cast light on certain psychic mechanisms that help to give meaning to death, in particular via objects of great symbolic value, as links between the dead and the survivors.MethodsIn this clinical article using a heuristic methodology, we combine the analysis of a clinical situation of antenatal death, a paradigm of loss with a pathological risk, and that of the artistic creation of Michel Nadjar, linked to the genocide of the Jews.ResultsThe psychic processing of the loss of a loved one is accompanied by considerable psychopathological risk. While funeral rites, whether religious or lay, and the support of the family and the community often provide mourners with a framework that favours the achievement of the period of mourning, so as to continue living with the loss (rather than living with the deceased person), there are certain traumatic situations that make access to a non-pathological mourning process impossible.DiscussionThe authors reappraise the exclusiveness of Freud's mourning and melancholia model, and consider Winnicott's theoretical model of transitional phenomena to cast light on the psychic processes at work.ConclusionsThe creativity operating in the two situations maintains a certain distinction: sublimation for the artist, resurgence of transitional phenomena for the bereaved individual. 相似文献
59.
《Injury》2022,53(4):1422-1429
PurposeThis study examined soft-tissue coverage techniques of open tibia fractures, described soft-tissue treatment patterns across income groups, and determined resource accessibility and availability in Latin America.MethodsA 36-question survey was distributed to orthopaedic surgeons in Latin America through two networks: national orthopaedic societies and the Asociación de Cirujanos Traumatólogos de las Am233;ricas (ACTUAR). Demographic information was collected, and responses were stratified by income groups: high-income countries (HICs) and middle-income countries (MICs).ResultsThe survey was completed by 469 orthopaedic surgeons, representing 19 countries in Latin America (2 HICs and 17 MICs). Most respondents were male (89%), completed residency training (96%), and were fellowship-trained (71%). Only 44% of the respondents had received soft-tissue training. Respondents (77%) reported a strong interest in attending a soft-tissue training course. Plastic surgeons were more commonly the primary providers for Gustilo Anderson (GA) Type IIIB injuries in HICs than in MICs (100% vs. 47%, p<0.01) and plastic surgeons were more available (<24 h of patient presentation to the hospital) in HICs than MICs (63% vs. 26%, p = 0.05), demonstrating statistically significant differences. In addition, respondents in HICs performed free flaps more commonly than in MICs for proximal third (55% vs. 10%, p<0.01), middle third (36% vs. 9%, p = 0.02), and distal third (55% vs. 10%, p<0.01) lower extremity wounds. Negative Pressure Wound Therapy (NPWT or Wound VAC) was the only resource available to more than half of the respondents. Though not statistically significant, surgeons reported having more access to plastic surgeons at their institutions in HICs than MICs (91% vs. 62%, p = 0.12) and performed microsurgical flaps more commonly at their respective institutions (73% vs. 42%, p = 0.06).ConclusionsThe study demonstrated that most orthopaedic surgeons in Latin America have received no soft-tissue training, HICs and MICs have differences in access to plastic surgeons and expectations for flap type and timing to definitive coverage, and most respondents had limited access to necessary soft-tissue surgical resources. Further investigation into differences in the clinical outcomes related to soft-tissue coverage methods and protocols can provide additional insight into the importance of timing and access to specialists. 相似文献
60.
Abraham Manoj-Thomas A Gadgil 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》2006,16(2):178-180
Nutcracker fracture of the cuboid is a rare injury usually caused by forced abduction of the forefoot on a fixed hindfoot. We report a case of this fracture in a 58-year-old man who was treated on the principle of ligamentotaxis and the position being held with Kirchner wires for a period of 5 weeks. He recovered without any complications and with good ankle and subtalar movements. At 5 months following the injury he had returned to his previous occupation. We think this novel way of treating this rare fracture is simple and gave a good result in this patient. 相似文献