Validation of the histogram technique for three-dimensional and two-dimensional dosimetric calculations

Three-dimensional discrete dosimetric calculations were validated against an analytic approach for two simulated source distributions. The discrete approach was based on characterization of the source distribution by target-source distance histograms, including partial interval corrections. Using local submatrices and distance histograms, accurate dose rates were obtained for ⁹⁰Y, ¹³¹I and ⁶⁷Ga. Comparison of three- and two-dimensional calculations revealed that the latter were accurate, except for long range emitters.     

中医象思维与知行合一

“象”诊察是中医诊查的关键手段,象思维则是贯穿整个辨证论治过程的主要思维模式.“知行”是中国传统哲学的重要范畴,而知行合一是象思维的基本要求.象思维在中医学中应用广泛,贯穿了中医学诸多方面,无论是中医基础理论中的气、阴阳、五行、藏象病机,还是中医临床基础中的诊断、治则、方药等.象思维具有整体性、多样性和模糊性的特点,要...     

TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration

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Dendritic cell type 3 arises from Ly6C+ monocyte-dendritic cell progenitors

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Bioresponsive immune-booster-based prodrug nanogel for cancer immunotherapy

The combination of chemotherapy and immunotherapy motivates a potent immune system by triggering immunogenic cell death (ICD), showing great potential in inhibiting tumor growth and improving the immunosuppressive tumor microenvironment (ITM). However, the therapeutic effectiveness has been restricted by inferior drug bioavailability. Herein, we reported a universal bioresponsive doxorubicin (DOX)-based nanogel to achieve tumor-specific co-delivery of drugs. DOX-based mannose nanogels (DM NGs) was designed and choosed as an example to elucidate the mechanism of combined chemo-immunotherapy. As expected, the DM NGs exhibited prominent micellar stability, selective drug release and prolonged survival time, benefited from the enhanced tumor permeability and prolonged blood circulation. We discovered that the DOX delivered by DM NGs could induce powerful anti-tumor immune response facilitated by promoting ICD. Meanwhile, the released mannose from DM NGs was proved as a powerful and synergetic treatment for breast cancer in vitro and in vivo, via damaging the glucose metabolism in glycolysis and the tricarboxylic acid cycle. Overall, the regulation of tumor microenvironment with DOX-based nanogel is expected to be an effectual candidate strategy to overcome the current limitations of ICD-based immunotherapy, offering a paradigm for the exploitation of immunomodulatory nanomedicines.