全文获取类型
收费全文 | 383篇 |
免费 | 16篇 |
国内免费 | 2篇 |
专业分类
儿科学 | 12篇 |
妇产科学 | 1篇 |
基础医学 | 34篇 |
口腔科学 | 2篇 |
临床医学 | 14篇 |
内科学 | 194篇 |
神经病学 | 3篇 |
特种医学 | 1篇 |
外科学 | 9篇 |
综合类 | 8篇 |
预防医学 | 112篇 |
药学 | 8篇 |
肿瘤学 | 3篇 |
出版年
2023年 | 14篇 |
2022年 | 11篇 |
2021年 | 14篇 |
2020年 | 34篇 |
2019年 | 16篇 |
2018年 | 20篇 |
2017年 | 10篇 |
2016年 | 15篇 |
2015年 | 33篇 |
2014年 | 49篇 |
2013年 | 33篇 |
2012年 | 19篇 |
2011年 | 11篇 |
2010年 | 28篇 |
2009年 | 15篇 |
2008年 | 6篇 |
2007年 | 6篇 |
2006年 | 6篇 |
2005年 | 11篇 |
2004年 | 2篇 |
2003年 | 4篇 |
2002年 | 7篇 |
2001年 | 5篇 |
2000年 | 5篇 |
1999年 | 5篇 |
1998年 | 3篇 |
1997年 | 3篇 |
1996年 | 3篇 |
1995年 | 1篇 |
1993年 | 2篇 |
1992年 | 2篇 |
1991年 | 1篇 |
1990年 | 3篇 |
1989年 | 1篇 |
1986年 | 1篇 |
1973年 | 1篇 |
1954年 | 1篇 |
排序方式: 共有401条查询结果,搜索用时 15 毫秒
71.
72.
《Vaccine》2020,38(37):5923-5926
BackgroundOn 12/23/2009 a new high-dose trivalent inactivated influenza vaccine (IIV3-HD) was licensed for adults aged ≥65 years. We assessed the post-licensure safety data for IIV3-HD in the Vaccine Adverse Event Reporting System (VAERS) during 2011–2019.MethodsWe searched VAERS for reports after IIV3-HD during 1/1/2011–06/30/2019 in persons aged ≥65 years. Medical records were reviewed for all death reports and for certain pre-specified conditions (e.g. Guillain Barré Syndrome [GBS], anaphylaxis). We also reviewed certain groups who received IIV3-HD erroneously (e.g. pregnant women, children). Empirical Bayesian data mining was used to identify disproportional reporting.ResultsVAERS received 12,320 reports after IIV3-HD;723 reports (5.9%) were serious. The most common adverse events (AEs) among serious reports were pyrexia (30.2%), asthenia (28.9%), and dyspnea (24.9%), and among non-serious reports were injection site erythema (16.8%), pain in extremity (15.8%), and injection site pain (14.2%). Among 55 death reports, the most common causes of death were diseases of the circulatory system (n = 23;41.8%). Based on medical record review, there were 61 reports of GBS and 13 of anaphylaxis. There were 13 reports of pregnant-women who inadvertently received IIV3-HD; three reports described arm pain or local reactions, and 10 did not report any AE. Among 59 reports of children who erroneously received IIV3-HD, 31 experienced an AE (most commonly injection site or constitutional reactions) and the remaining 28 reports did not describe any AE.ConclusionsPost-licensure safety data of IIV3-HD during 9 influenza seasons revealed no new or unexpected safety concerns among individuals ≥65 years. Inadvertent administration of IIV3-HD to children or pregnant women was observed, although with no serious AEs reported. Training and education of providers in vaccine recommendations and groups for whom the vaccine is indicated may help in preventing these vaccine administration errors. This review provides baseline information for future monitoring of the quadrivalent-high-dose influenza vaccine. 相似文献
73.
Daniel Oshi Joseph Chukwu Charles Nwafor Ngozi E. Chukwu Anthony O. Meka Moses Anyim Kingsley N. Ukwaja Isaac Alobu Ngozi Ekeke Sarah N. Oshi 《The International journal of health planning and management》2020,35(4):832-842
Multidrug-resistant tuberculosis (MDR-TB) is presently a major public health threat. MDR-TB patients face diverse financial and psychosocial difficulties. Researchers conducted in-depth interviews based on interview guides with 42 participants. Data were analyzed using categorization, coding, generation of themes, and thematic memo writing. The key findings were as follows: Out of the 42 patients, 30 (71.4%) were males and 12 (28.6%) were females. All patients received financial stipends for transport and monthly social support. The patients however needed more financial support than they received (suggesting high unmet financial needs). Patients suffered depressive mood before and during treatment but received inadequate mental health/psychosocial care and treatment. Patients developed hearing impairment as a major adverse drug reaction, but the care and treatment they received were inadequate. In conclusion, the programmatic support provided for MDR-TB patients' financial and mental health/psychosocial needs and auditory drug side effects fell short of their need. Programmes for control of MDR-TB should increase budgetary allocations and ramp up mechanisms for provision of mental health/psychosocial support and care/treatment for drug side effects. 相似文献
74.
75.
Redefining MDR-TB: Comparison of Mycobacterium tuberculosis clinical isolates from Russia and Taiwan
Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis are global challenges due to the limited number of effective drugs for treatment. Treatment with less than 4–5 effective drugs might lead to the further emergence of drug resistance and poor clinical outcomes. For better prediction of treatment outcomes, we compared drug-resistance profiles of consecutive clinical MDR Mycobacterium tuberculosis isolates from high- and low-burden settings.This was a retrospective cohort study. We analysed 225 and 229 MDR isolates from Moscow (Russia) and Taiwan, respectively, obtained between 2014 and 2015. Drug susceptibility testing was performed by the Bactec MGIT 960 automated system and the agar proportion method. Detection of resistance-associated mutations in the M. tuberculosis genome was carried out by an array and/or sequencing of selected loci.The principal differences between resistance profiles of MDR isolates in the two countries were the percentages of pre-XDR (40.9% vs. 14.8%) and XDR (34.7% vs. 1.7%) isolates, both of which were significantly higher in Moscow isolates. Forty-eight (33%) of 147 MDR and pre-XDR Russian isolates fall into a group with less than four effective drugs, which accounts for 40% (N = 120) of these isolates. The other 60% in this group were XDR strains (N = 72). Consequently, the average number of effective anti-tuberculosis drugs for MDR-TB treatment was lower for Russian isolates (3 vs. 7). Furthermore, a notable percentage (9%) of isolates resistant to kanamycin harboured mutations in the whiB7 locus, which was not detected by molecular tests targeting common mutations in the rrs and eis loci. We found that 98.2% and 45.9% of MDR isolates from Moscow and Taiwan, respectively, were resistant to streptomycin.Molecular tests for detecting resistance to drugs other than rifampicin, isoniazid, fluoroquinolones, and second-line injectable drugs are needed for individualized therapy. The conventional MDR treatment schemes most probably fail in these cases due to the limited number of effective drugs. 相似文献
76.
78.
《Paediatrics & Child Health》2008,18(7):329-332
Specific allergen immunotherapy is the only potentially curative allergy treatment currently available. It is used in Europe and North America in the treatment of allergic rhinitis, venom allergy and asthma in children. However, following a series of deaths in the 1980s, the use of immunotherapy in the UK is limited to a small number of specialist allergy clinics. This article reviews the route of administration, safety, efficacy and indications for specific allergen immunotherapy in children. New developments in immunotherapy are discussed. 相似文献
79.
80.