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991.
Lu Zhang Xiangyu Ma Zhi Jiang Kejun Zhang Mengxuan Zhang Yafei Li Xiaolan Zhao Hongyan Xiong 《Oncotarget》2015,6(29):26782-26788
Previous studies suggested that elevated liver enzymes could be used as potential novel biomarkers of Metabolic syndrome (MetS) and its clinical outcomes, although the results were inconsistent and the conclusions were underpowered. A case-control study with 6,268 MetS subjects and 6,330 frequency-matched healthy controls was conducted to systematically evaluated levels of four liver enzymes (ALT, AST, GGT and ALP), both in overall populations and in subjects with normal liver enzymes, with MetS risk using both quartiles and continuous unit of liver enzymes. We found significant associations were detected for all above analyses. Compared with quartile 1 (Q1), other quartiles have significant higher MetS risk, with ORs ranging from 1.15 to 18.15. The highest effected was detected for GGT, for which the OR value for the highest versus lowest quartile was 18.15 (95% CI: 15.7-20.9). Mutual adjustment proved the independence of the relations for all four liver enzymes. Sensitivity analyses didn’t materially changed the trend. To the best of our knowledge, this study should be the largest, which aimed at evaluating the association between liver enzymes measures and MetS risk. The results can better support that liver enzyme levels could be used as clinical predictors of MetS. 相似文献
992.
993.
目的筛查中国女性乳腺癌发病相关危险因素,为个体化评估中国女性乳腺癌发病危险性提供依据。方法在全国8个省市14家研究中心开展1∶m配对病例对照研究,采用调查问卷通过面对面交流收集乳腺癌发病相关危险因素信息。乳腺癌患者及其配对健康对照女性年龄、生活环境相匹配。应用1∶m条件Logistic回归分析乳腺癌相关危险因素在病例组和对照组间的分布特点,明确其与乳腺癌发病危险性的相关性。结果共纳入416例乳腺癌患者及1156例健康对照女性。中国女性乳腺癌发病相关危险因素包括体重指数(body mass index,BMI)≥24(OR=4.07,95%CI:2.98~5.55),乳腺良性病变活检史(OR=1.68,95%CI:1.19~2.38),初潮年龄≥14岁(OR=1.41,95%CI:1.07~1.87),生存压力大(1~4级,OR=2.15,95%CI:1.26~3.66;5~9级,OR=3.48,95%CI:2.03~5.95),绝经(OR=2.22,95%CI:1.50~3.28)(P〈0.05),乳腺癌家族史(OR=1.72,95%CI:1.15~2.58),肿瘤家族史(乳腺癌除外)(OR=1.55,95%CI:1.22~1.98)。口服避孕药(OR=1.59,95%CI:0.83~3.05)亦增加乳腺癌发病危险性,但差异未达到显著统计学意义(P〉0.05)。结论中国女性乳腺癌发病相关危险因素包括BMI≥24、乳腺良性病变活检史、初潮年龄≥14岁、生存压力大、绝经、乳腺癌家族史及其他肿瘤家族史。本研究为个体化评估中国女性罹患乳腺癌危险性及广泛开展乳腺癌防治工作提供了依据。 相似文献
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995.
《Clinics and research in hepatology and gastroenterology》2022,46(7):101987
BackgroundThere is huge shortage of ERCP practitioners (ERCPists) in China, and ERCP training is urgently needed. ChangHai Advanced eNdoscopy Courses for ERCP (CHANCE) is a 4-month program for ERCP training since 2004. This study evaluated the efficiency of this short-term training model, and reported on the ERCP careers of the trainees following completion of the CHANCE program.MethodsThis study was a retrospective investigation included all the CHANCE trainees from Jan 2004 to Dec 2014. Questionnaires were sent to all trainees. The career competence percentage, ERCP careers and predictive factors of career competence were investigated and analyzed.ResultsA total of 413 trainees participated in the CHANCE program over 11 years covered by the survey and 258 questionnaires were valid for the study. The mean (SD) age of the trainees was 35.36 (4.17), and the male to female ratio was 4.4:1. The average follow-up time was 7.77 (3.44) years. A total of 173 (67.1%) trainees had achieved career competence. In terms of ERCP careers, the mean annual ERCP volume was 120.60 (96.67), with a complication percentage of 8.2%. Hospital qualification, compliance with follow-up learning guidance, participating academic activity, and practitioner type were identified predictive factors of career competence.ConclusionsAs a short-term training program, the CHANCE achieved an acceptable career competence percentage, providing endoscopists more chances to learn ERCP and giving them appropriate training guidance for career competence. This training mode is worth promoting in developing countries with shortage of ERCPists. 相似文献
996.
《HPB : the official journal of the International Hepato Pancreato Biliary Association》2022,24(7):1063-1073
BackgroundMicrovascular invasion (MVI) is a risk factor of post-hepatectomy tumor recurrence for hepatocellular carcinoma (HCC). The patterns, treatments, and prognosis have not been documented in HCC patients with MVI.MethodsA multicenter database of patients with HCC and MVI following resection was analyzed. The clinicopathological and initial operative data, timing and first sites of recurrence, recurrence management, and long-term survival outcomes were analyzed.ResultsOf 1517 patients included, the median follow-up was 39.7 months. Tumor recurrence occurred in 928 patients, with 49% within 6 months of hepatectomy and 60% only in the liver. The incidence of intrahepatic only recurrence gradually increased with time after 6 months. Patients who developed recurrence within 6 months of hepatectomy had worse survival outcomes than those who developed recurrence later. Patients who developed intrahepatic only recurrence had better prognosis than those with either extrahepatic only recurrence or those with intra- and extrahepatic recurrence. Repeat resection of recurrence with curative intent resulted in better outcomes than other treatment modalities.ConclusionPost-hepatectomy tumor recurrence in patients with HCC and MVI had unique characteristics and recurrence patterns. Early detection of tumor recurrence and repeat liver resection with curative intent resulted in improved long-term survival outcomes. 相似文献
997.
《Current problems in cardiology》2022,47(9):101269
Our study aims to compare the utility of single antiplatelet therapy (SAPT) with dual antiplatelet therapy (DAPT) following Left atrial appendage occlusion in patients whose post-procedural oral anticoagulation therapy was deemed high-risk or contraindicated. A total of 14 observational studies with 3,151 patients were included. Our study demonstrates that SAPT and DAPT were similar in preventing device-related thrombosis. Although SAPT and DAPT had a tendency toward a higher risk for stroke and major bleeding respectively, these differences did not reach statistical significance. Large-scale Randomized Controlled Studies are warranted to validate if our results could be translated into clinical practice. 相似文献
998.
999.
目的 探讨甲状旁腺激素(parathyroid hormone,PTH)是否诱导血管内皮细胞上皮细胞-间充质转化(endothelial-mesenchymal transition,EndMT)及相关机制.方法 血管内皮细胞HAEC培养至对数期,分别加入不同剂量的全长重组PTH(10-12 mol/L、10-11 mol/L、10-10mol/L、10-9mol/L、10-8mol/L)作用48h;再在10-8mol/L PTH作用下,选择12、24、36、60h 4个时间点;分别收集总蛋白.Western blot分析Ve-Cadherin、CD31、α-SMA、TGF-β1和ILK的表达改变.结果 Western blot结果表明在PTH作用下,血管内皮细胞标志分子Ve-Cadherin和CD31表达降低;纤维细胞标志分子α-SMA表达则显著升高,且呈时间和剂量依赖性.Western blot分析发现TGF-β1和ILK表达同时升高.结论 PTH减弱内皮细胞特征、增强纤维化特征,诱导HAEC细胞发生EndMT,TGF-β1-ILK通路是其调控的可能通路之一. 相似文献
1000.
ObjectiveThere is initial evidence that the use of volatile anesthetics can reduce the postoperative release of cardiac troponin I, the need for inotropic support, and the number of patients requiring prolonged hospitalization following coronary artery bypass graft (CABG) surgery. Nevertheless, small randomized controlled trials have failed to demonstrate a survival advantage. Thus, whether volatile anesthetics improve the postoperative outcome of cardiac surgical patients remains uncertain. An adequately powered randomized controlled trial appears desirable.DesignSingle blinded, international, multicenter randomized controlled trial with 1:1 allocation ratio.SettingTertiary and University hospitals.InterventionsPatients (n = 10,600) undergoing coronary artery bypass graft will be randomized to receive either volatile anesthetic as part of the anesthetic plan, or total intravenous anesthesia.Measurements and main resultsThe primary end point of the study will be one-year mortality (any cause). Secondary endpoints will be 30-day mortality; 30-day death or non-fatal myocardial infarction (composite endpoint); cardiac mortality at 30 day and at one year; incidence of hospital re-admission during the one year follow-up period and duration of intensive care unit, and hospital stay. The sample size is based on the hypothesis that volatile anesthetics will reduce 1-year unadjusted mortality from 3% to 2%, using a two-sided alpha error of 0.05, and a power of 0.9.ConclusionsThe trial will determine whether the simple intervention of adding a volatile anesthetic, an intervention that can be implemented by all anesthesiologists, can improve one-year survival in patients undergoing coronary artery bypass graft surgery. 相似文献