全文获取类型
收费全文 | 1373篇 |
免费 | 57篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 27篇 |
妇产科学 | 29篇 |
基础医学 | 165篇 |
口腔科学 | 5篇 |
临床医学 | 69篇 |
内科学 | 452篇 |
皮肤病学 | 35篇 |
神经病学 | 10篇 |
特种医学 | 1篇 |
外科学 | 14篇 |
综合类 | 20篇 |
预防医学 | 511篇 |
眼科学 | 1篇 |
药学 | 78篇 |
中国医学 | 1篇 |
肿瘤学 | 11篇 |
出版年
2023年 | 22篇 |
2022年 | 17篇 |
2021年 | 33篇 |
2020年 | 79篇 |
2019年 | 40篇 |
2018年 | 70篇 |
2017年 | 57篇 |
2016年 | 61篇 |
2015年 | 82篇 |
2014年 | 107篇 |
2013年 | 109篇 |
2012年 | 101篇 |
2011年 | 82篇 |
2010年 | 63篇 |
2009年 | 67篇 |
2008年 | 48篇 |
2007年 | 55篇 |
2006年 | 51篇 |
2005年 | 36篇 |
2004年 | 25篇 |
2003年 | 38篇 |
2002年 | 44篇 |
2001年 | 37篇 |
2000年 | 38篇 |
1999年 | 28篇 |
1998年 | 6篇 |
1997年 | 3篇 |
1996年 | 9篇 |
1995年 | 4篇 |
1994年 | 7篇 |
1993年 | 6篇 |
1992年 | 3篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1988年 | 1篇 |
排序方式: 共有1431条查询结果,搜索用时 15 毫秒
991.
Bocaparvoviruses have been studied extensively owing to their ability to cause respiratory illness or gastroenteritis in humans. Some bocaparvoviruses have been detected in non-human primates (gorillas and chimpanzees), but the diversity and evolution of these viruses are not fully understood. In this study, we collected 107 fecal samples from wild western lowland gorillas in Moukalaba-Doudou National Park in Gabon to investigate the presence of bocaparvoviruses. Using a combination of pan-bocaparvovirus PCR and individual identification by microsatellite genotyping, we found that two samples from two apparently healthy infant gorillas were positive for bocaparvovirus. Sequencing and phylogenetic analyses revealed that the two gorilla bocaparvovirus strains are nearly identical and are closely related to viruses in the species Primate bocaparvovirus 2 (with 86.0% nucleotide identity to a human bocavirus 2 isolate). To our knowledge, this is the first report showing the presence of a non-human primate bocaparovirus within Primate bocaparvovirus 2. Our findings provide novel insights into the diversity and evolution of bocaparvoviruses and highlight the importance of surveying these viruses for the safe management of gorilla-based ecotourism. 相似文献
992.
M Rader G Marks G Mansergh N Crepaz L C Miller P R Appleby S Murphy 《AIDS education and prevention》2001,13(2):149-159
This study of men who have sex with men (MSM) examined preferences about the characteristics of a potential product for preventing sexual transmission of HIV, such as a rectal microbicide. MSM were recruited in West Hollywood, California. They self-administered a questionnaire and rated 48 product characteristics representing seven dimensions. Overall, the ratings were highest for effectiveness in preventing HIV and other sexually transmitted diseases, followed by characteristics reflecting the physical or secondary effects of the product and logistics of use. Physical attributes, convenience/accessibility, and psychological aspects had intermediate ratings; interpersonal dynamics had the lowest rating. Men with negative attitudes about using condoms to prevent HIV infection were more likely than their counterparts to prefer a product that does not reduce sexual sensation or pleasure, does not break the mood, and can be used after a sexual encounter ends. A similar pattern was observed when participants were stratified by whether or not they had engaged in unprotected anal intercourse in the past 12 months. The findings inform the development, testing, and marketing of a future HIV prevention product for MSM. 相似文献
993.
994.
995.
996.
Marie Chevret-Méasson Emmanuel Lavallée Sylvie Troy Benoit Arnould Séverine Oudin Beatrice Cuzin 《The journal of sexual medicine》2009,6(3):761-769
IntroductionWomen's quality of sexual life is strongly impaired by erectile dysfunction (ED). Women's involvement in ED treatment is important for compliance and long-term efficacy but remains difficult. The Index of Sexual Life (ISL), specific of the quality of sexual life of women with ED partners, is used here to assess the impact of ED treatment on female partners.AimThe study explored in a context close to routine clinical practice the effect of sildenafil citrate (Viagra®; Pfizer, New York, NY, USA) treatment on women's quality of sexual life, in parallel with men's ED evaluations.MethodsThis prospective, open-labeled clinical trial was performed in France in 2006. Sexologists and andrologists recruited 67 volunteer couples for a 14-week sildenafil citrate treatment of male partners, without sex therapy in parallel.Main Outcome MeasuresWomen's quality of sexual life using ISL, and men's ED using International Index of Erectile Function (IIEF) and Self-Esteem And Relationship (SEAR) were assessed at baseline and at the end of the study. Satisfaction for treatment was measured using Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) and EDITS Partner.ResultsThe ISL sexual life satisfaction score was low at baseline (12.3), and increased by 8.3 during the study (P < 0.0001). Women were 79.0% to be responders according to ISL assessment. The other ISL dimensions also improved. The final ISL sexual life satisfaction score was dependant on women's age and final IIEF scores. The observed correlations between the ISL sexual life satisfaction dimension and the IIEF erectile function dimension, and the SEAR confidence dimension confirmed our assumptions. Both partners were highly satisfied with the treatment.ConclusionWomen satisfaction with their sex life was improved by ED treatment (sildenafil citrate). Couple global caring seemed to amplify the well-known effect of ED treatment for men. The ISL could be a useful tool to help women in their partner's treatment and to integrate ED treatment in a couple approach. Chevret-Méasson M, Lavallée E, Troy S, Arnould B, Oudin S, and Cuzin B. Improvement in quality of sexual life in female partners of men with erectile dysfunction treated with sildenafil citrate: Findings of the index of sexual life (ISL) in a couple study. J Sex Med 2009;6:761–769. 相似文献
997.
Drs. Meg C. Doherty MD PhD MPH Richard S. Garfein PhD MPH Dr. Edgar Monterroso MD MPH Dr. Carl Latkin ScD Dr. David Vlahov PhD 《Journal of urban health》2000,77(3):396-414
To characterize the circumstances surrounding initiation of injecting drug use, data were collected from 229 young, recently
initiated injection drug users enrolled through community-based recruitment in Baltimore, Maryland. Gender differences in
the pattern of initiation, the number of persons present at initiation, risky injection, and sexual behaviors at initiation,
as well as behaviors after initiation, were examined. Overall, men and women were similar statistically with respect to age
at initiation (19.5 years) and risk behaviors at initiation. While men were initiated by men (77%), women were more often
initiated by women (65%), most of whom were friends (75%) or relatives (23%). The percentage of women infected with human
immunodeficiency virus (HIV) was slightly greater than that of men, 17% versus 11% (P<.2), whether initiated by a man or a woman. Persons who self-initiated had a lower HIV prevalence and fewer HIV-related risk
behaviors. Analysis of variance assessed differences in the HIV risk profiles of female and male IDUs who were intiated by
someone of the same sex, of the opposite sex, or who self-initiated. These results indicated that (1) young women and men
had similar patterns of injection initiation; (2) most women were initiated by female friends, runing counter to earlier literature
claims that women were initated to injection drug use by male sex partners; and (3) women initiated by men had a marginally
greater mean score on the HIV risk profile. 相似文献
998.
R A Otten D L Ellenberger D R Adams C A Fridlund E Jackson D Pieniazek M A Rayfield 《The Journal of infectious diseases》1999,180(3):673-684
The potential to establish dual retroviral infections was investigated in this study. Groups of macaques infected with human immunodeficiency virus type 2 (HIV-2) isolate (either GB122 or CDC77618) were exposed to the other virus at 2, 4, 8, 12, 14, or 72 weeks after primary inoculation. Dual infections were established in macaques simultaneously exposed to both viruses. In other groups, secondary infections were observed only if challenge occurred at early intervals after primary infection but before a full seroconversion. Polymerase chain reaction and virus-isolation data demonstrated that challenges at 8, 12, 14, or 72 weeks after infection with the initial isolate failed to result in a dual infection. Anti-HIV-2 serologic titers, CD4 levels, virus burden, and the ability to superinfect peripheral blood mononuclear cells in vitro were not correlated with susceptibility to or protection from secondary challenges in this investigation. These findings demonstrate a window period for susceptibility to dual infection and indicate that protection from retroviral infection may be achievable. 相似文献
999.
1000.