血清基质金属蛋白酶3与颈动脉粥样硬化斑块及缺血性脑卒中的关系

Objective To investigate the relationship between the matrix metalloproteinase-3(MMP-3)and the stability of carotid artery plaque,and explore MMP-3's prediction role on the attack and relapse of acute ischemic cerebrovascular events.Methods 100 patients with the first ever acute cerebral infarction,100 patients with chronic cerebral circulation insufficiency(CCCI)and 40 persons without cerebrovascular diseases were enrolled in this study.According to the carotid ultrasound examination,100 cerebral infarction patients were divided into three subgroup: unstable plaque group(45 patients,mixed plaque,soft plaque),stable plaque group(35 patients,plaque Group)and endometrial coarse group(25patients).Matrix metalloproteinase-3(MMP-3)levels of all the subjects were measured by enzyme-linked immunosorbent assay(as basal level).All the subjects were followed up for one year to observe cerebral infarction events.Serum MMP-3 levels of each group,and the basic serum MMP-3 levels were compared among patients who were attacked or relapsed cerebral ischemic with those who had not been attack cerebral ischemic during this period of time.Results 5 patients in the cerebral infarction group had relapse (5%),2 patients in the CCCI group were attacked by cerebral ischemic(2%),and no one in the normal control group was attacked by cerebral ischemic.Serum MMP-3 levels in the acute cerebral infarction group were significantly higher than CCCI group,and both groups were significantly higher than normal control group (P ＜0.05).The basic serum MMP-3 levels in all patients who were attacked by cerebral ischemic were significantly higher than those who had not been attack by cerebral ischemic during this period of time(P ＜0.05).The serum MMP-3 levels of the unstable plaque group were significantly higher than stable plaque group.And both groups were significantly higher than endometrial coarse group(P ＜0.05).Conclusions Elevated levels of matrix metalloproteinase-3(MMP-3)might have something with the stability of carotid atherosclerotic plaque,and participate the attack and the relapse of acute cerebral infarction.Determination of MMP-3 might be used to predict the attack and relapse of acute cerebral infarction.     

初次接受化疗青少年白血病病人对护理人员期望的质性研究

[目的]了解首次接受化疗青少年白血病病人对护理人员期望。[方法]采用现场录音和笔录,对19例青少年病人进行半结构化深入访谈,运用Colaizzi分析程序进行结果分析。[结果]初次接受化疗青少年白血病病人需要护士具有良好的沟通能力、精湛的技术水准、扎实的理论知识和贴切的服务理念。[结论]应该针对初次接受化疗青少年白血病病人的特点给予针对性护理。     

实时定量RT-PCR测定急性白血病Cyclin D1 mRNA的表达

目的 研究急性白血病患者细胞周期调控蛋白D1 (Cyclin D1)不同水平的表达,探讨Cyclin D1在急性白血病中的作用机制和临床意义.方法 采用荧光实时定量RT-PCR方法检测51例急性白血病(AL)患者Cyclin D1 mRNA水平表达,良性血液病对照组16例.结果 急性白血病组Cyclin D1表达明显高于对照组;急性體系白血病(AML)与急性淋巴细胞白血病(ALL)组间Cyclin D1表达水平无显著差异性;难治复发组Cyclin D1表达水平最高,初发未治组次之,完全缓解组最低;初发未治组中随访的治疗后未缓解组Cyclin D1表达水平高于完全缓解组.结论 Cyclin D1与临床病情进展程度有一定的关系,尤其与病情的复发关系较为密切,动态观察患者Cyclin D1水平变化可作为评价患者治疗效果及预后的指标之一.     

半夏天麻白术汤治疗癫痫的疗效观察

采用李东垣的半夏天麻白术汤治疗癫痫41例,显效19例,占46.34％;有效13例,占31.71％;效差3例,占7.32％;无效6例,占14.63％。总有效率85.37％。同时检测了患者外周血的T细胞亚群CD_3、CD_4、CD_8的百分率均较正常人显著下降,而白细胞介素2受体的百分率却较正常人显著升高。经治疗后CD_3、CD_4的百分率显著回升,白细胞介素2受体百分率则显著下降,但仍未恢复至正常水平。     

骨疏灵胶囊治疗骨质疏松症的临床研究

骨疏灵胶囊治疗骨质疏松症的临床研究山西医学院第二附属医院（０３０００１）张剑宇，罗润明榆社阿胶厂杨庆文榆社县人民医院陈竹青关键词骨质疏松症，骨疏灵胶囊，临床研究我们对山西榆社阿胶厂研制的治疗骨质疏松症新药──骨疏灵胶囊进行了Ⅱ期临床试验。结果：治疗组...     

加温并丝裂霉素C治疗小鼠艾氏实体癌的光镜、电镜研究

本文用移植性艾氏实体癌的瑞士系小鼠研究高温治疗或丝裂霉素Ｃ治疗及二者联合应用的效果。实验结果：高温的治愈率为５０％；高温并用丝裂霉素Ｃ的治愈率为８８％。提示二者并用显著地提高治癌的效果。本研究支持丝裂霉素Ｃ有阻止产生耐热现象的论点，二者均能导致ＤＮＡ合成障碍，并发挥协同作用。     

医院感染与肿瘤病人的护理

医院感染也就是医院内感染，也叫医院获得性感染，指在医院内发生的一切感染，医院感染增加病人的痛苦，甚至造成死亡，而且加重医院工作人员的工作量和医疗任务，其造成的经济损失是巨大大的。     

黄体功能不全

黄体是内分泌器官,在孕卵着床与维持早孕上起重要作用。黄体功能不全是造成不孕与流产的重要原因。本症发生率为10～15%,占不孕的3.5%,占早孕流产的25%。本文从实用角度出发着重介绍黄体功能不全的诊断与治疗。一、黄体化过程的形态与机能变化:从卵泡成熟到黄体形成,是个连续过程,此过程即黄体化过程,可分为排卵前黄体化与排卵后黄体化。(一)排卵前黄体化:在LH 作用下,颗粒细胞增生、肥大,呈单相性向排卵前黄体化过渡,但排卵前由于卵泡液中抗黄体因子作用,使排卵前不能达到完全黄体化。内卵泡细胞在排卵的早、中期亦增     

HMG-HCG疗法的有关问题

本文介绍HMG连日肌注(75～300IU/日)、隔日肌注与脉冲式给药(9.357IU/90分、16次/日、150IU/日)法,后者排卵周期率最高(86.7%)。但由于个体对HMG反应不同,其用量用法应因人、因周期而异,以最小有效量为宜。研究证明发育卵泡面积总和(FA)与血E_2相关系数为0.81(P<0.001),可作为预测OHSS指标;最大卵泡长径(mFD)可作为判断卵泡成熟指标。认为FA<7cm~2、mFD>18mm为改用HCG较理想标准,排卵率87.1%,妊娠率30%,OHSS发生率0%。FA>7cm~2不宜用HCG,未达上述标准改用HCG虽可避免OHSS,但只有30%的排卵周期。     

非霍奇金淋巴瘤的恶性程度与DNA倍体关系的研究

非霍奇金淋巴瘤的恶性程度与ＤＮＡ倍体关系的研究姚宏，王全红，袁瑞香，甄惠莲，杨龙泉，赵玛丽，张庆升，王虹，路喜安，平苏萍非霍奇金淋巴瘤（ＮＨＬ）的流式细胞分析，对于判断其恶性程度，制定治疗方案及判断患者生存率有重要意义。我们应用流式细胞技术，探讨瘤细...