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《Annals of hepatology》2020,19(2):197-203
Introduction and objectivesThe purpose of this study was to confirm whether hepatitis B virus (HBV) infection and the levels of liver enzymes would increase the risk of prediabetes and diabetes mellitus (DM) in China.Materials and methodsA total of 10,741 individuals was enrolled in this prospective cohort study. Cox regression analysis was used to calculate the Hazard ratios (HRs) to evaluate the relationships between HBV infection and the risk of DM and prediabetes. Decision trees and dose response analysis were used to explore the effects of liver enzymes levels on DM and prediabetes.ResultsIn baseline population, HBV infection ratio was 5.31%. In non-adjustment model, the HR of DM in HBV infection group was 1.312 (95% CI, 0.529–3.254). In model adjusted for gender, age and liver cirrhosis, the HR of DM in HBV infection group were 1.188 (95% CI, 0.478–2.951). In model adjusted for gender, age, liver cirrhosis, smoking, drinking, the HR of DM was 1.178 (95% CI, 0.473–2.934). In model further adjusted for education, family income and occupation, the HR of DM was 1.230 (95% CI, 0.493–3.067). With the increases of levels of Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and Gamma-glutamyl transferase (GGT), the risk of prediabetes was gradually increasing (Pnon-linearity < 0.05). There were dose-response relationships between ALT, GGT and the risk of DM (Pnon-linearity < 0.05).ConclusionsHBV infection was not associated with the risk of prediabetes and DM. The levels of liver enzymes increased the risk of prediabetes and DM. 相似文献
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BAI Ya Na MA Li WANG Qiu Ying PU Hong Quan ZHANG Xiao Pei WU Xi Jiang XUAN Xiao Qiang 《Biomedical and environmental sciences : BES》2013,26(7):625-628
Nickel carbonyl is a highly toxic metal compound produced from the reaction that occurs between nickel and carbon monoxide under pressure.As previously reported,nickel carbonyl can cause acute aspiration pneumonia,and animal experiments showed it was toxic to animal lung,liver,brain,and other vital organs[1].However,few studies have investigated nickel carbonyl poisoning in humans[2].Current research has mainly focused on the carcinogenicity of nickel carbonyl and therapy by nickel carbonyl inhibition at the cytochrome level[3].Nevertheless,there is still a lack of studies on the mechanism of nickel carbonyl poisoning and its toxic effects on gene expression and gene regulation. 相似文献
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Huang JunJun Cao JiaNing Jiang Nan Bao KaiFang Ding Jie Chen XiaoLiang Cheng Ning Zhang DeSheng Li HaiYan Hu XiaoBin Zheng Shan Wang MinZhen Bai YaNa 《International journal of diabetes in developing countries.》2020,40(1):40-46
International Journal of Diabetes in Developing Countries - The present study aimed to investigate the role of GSD in different phases of type 2 DM development in the Jinchang cohort study. A total... 相似文献
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BAI Ya Na YAGN Ai Min PU Hong Quan HE Jie CHENG Ning ZHENG Tong Zhang DAI Min ZHANG Ya Wei BASSING Bryan A WANG Qiu Ying 《Biomedical and environmental sciences : BES》2014,(3):208-211
<正>There are more than 50 000 workers in Jinchuan Group Co,Ltd(JNMC).Since all staff in JNMC are eligible for a medical examination every two years,only 23 484 nickel-exposed subjects who participated in medical examination were included in this study.Their data,collected from June 22,2011 to September 28,2012,in a comprehensive 相似文献
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YANG Ai Min BAI Ya Na PU Hong Quan ZHENG Tong Zhang CHENG NingLI Juan Sheng LI Hai Yan ZHANG Ya Wei DING Jiao SU Hui REN Xiao Wei HU Xiao Bin 《Biomedical and environmental sciences : BES》2014,(6):475-477
<正>The prevalence of metabolic syndrome(MS was investigated in Chinese nickel-exposed workers A total of 35 104 subjects were enrolled in this study.The age-adjusted prevalence of MS,BMI≥25diabetes,hypertension,and abnormal lipid was13.9%,29.5%,12.8%,27.5%,and 47.1%respectively.The prevalence of BMI≥25hyperglycemia,and hypertension increased with 相似文献
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