排序方式: 共有3条查询结果,搜索用时 15 毫秒
1
1.
2.
Miao Jin Jinan Chen Xiao-hong Zhang Ming Zhang Hui-ying Li Wei-xia Cheng Na Liu Ming Tan Taijiao Jiang Zhao-Jun Duan 《Infection, genetics and evolution》2011,11(7):1716-1726
Little is known about the role of noroviruses (NVs) in sporadic cases of acute gastroenteritis in adults. The GII-4 NVs are currently the globally dominant genotype with diverse genetic makeups. The mechanism(s) underlying the persistence and rapid evolution of the viruses are not yet clear. In this study we collected 547 specimens from adult of >14 years of age with acute gastroenteritis in Beijing, China from September 2007 to Febraury 2008. NVs were screened and sequenced to determine their genotypes. Bioinformatics methods were used to detect NV recombination and their breakpoints. The residue variations of the capsid proteins between GII-4/Den Haag and previous predominant variants of GII-4 were compared to identify mutations that are likely important for current epidemic wave. Putative epitopes were predicted based upon the crystal structure. 106 (19.4%) NVs were identified among 547 specimens. While GII-4 remains predominant, at least six other genotypes were observed. Two recombinant types were identified with both predicted breakpoints locating within the 24–27 bp region upstream the start codon of ORF2. We found the emergent mutations H414P/Q of the capsid protein are specific for GII-4/Den Haag and this site lies within a predicted antibody-binding epitope. Our data demonstrated that NVs were an important cause of acute gastroenteritis in Chinese adults. The shared breakpoints identified in the GI and GII recombinants imply the presence of recombination hotspots in NVs. The mutations at residue 414 and its location within a putative antigenic epitope suggested a possible mechanism that may allow GII-4 NVs to escape from herd immunity. 相似文献
3.
《International journal of immunopharmacology》1995,17(8):663-676
Psychosocial factors and immunological markers have been associated not only with progression from HIV to AIDS, and AIDS survival, but also with wellness. Not yet identified, and therefore not yet formalized into a system for clinical decision-making, are those individual differences that moderate both the impact of psychosocial factors and the potential benefit of interventions. Therefore the link between theoretical knowledge and application has not yet been established in a manner that would predict the outcome of recommended interventions. Presented here are background considerations to a combination of short-term and longitudinal studies which investigate these issues. The decision process devised here would be suitable for use with individuals with any physical disorder that has a psychosocial component. 相似文献
1