人颅面骨三维有限元模型的建立

目的利用计算机辅助技术,建立颅面骨三维有限元模型,为颌面部火器伤的生物力学分析奠定基础。方法通过薄层螺旋CT扫描正常志愿者颌面部,将获得的颅面骨数据通过Mimics软件进行三维实体重建,利用ANSA软件进行布尔运算,生成颅面骨骼,进行网格划分。结果建立了上颌骨、下颌骨等颅面骨三维有限元模型。结论利用薄层CT,结合Mimics、ANSA软件建立的颅面骨有限元模型真实准确,建立方法实用,可根据枪弹伤情况进行不同的生物力学分析。     

医用气体中心供应系统及应急安全质量控制

目的:针对医院医用气体中心供应系统安全运行实际情况,介绍现代医院医用气体中心供应系统构成和运行流程。方法:结合本单位医用气体中心供应站的扩建设计及运用,推荐扩建系统设计与原中心供气系统链接。结果:两系统互为应急作用,既符合国家对医用气体一用一备一应急标准要求,又有效保证了突发事件出现时医院的安全用氧。同时在应急安全质量控制上从设计、材质、安装以及在日常检查和维护中强化过程质量安全管理;加强工程技术人员的系统培训;做好安全档案管理,逐级落实应急措施,责任到人。结论:提出本单位所运用的设计不但工程量不大,经费不高,且安全可靠,在全院医用气体系统工程的应急预案中达到使用安全放心的目的。     

Racial variations in knee joint laxity: A comparative study of the Jordanian Arab and Malay populations

BackgroundA high incidence of joint laxity has been reported among Asians compared with Western populations, but clear differences between more specific ethnic populations have not been established. This study aimed to determine the average knee laxity in the Malaysian and Jordanian populations.MethodsJordanian and Malaysian medical students from our institution were invited to participate in the study. General demographic data and factors affecting joint laxity were obtained from each participant using a printed questionnaire. Both knees were examined using the anterior drawer test while in 90° of flexion. Knee laxity was measured by three separate independent investigators through a knee laxity tester.ResultsOne hundred and eighty-six participants (95 females) were enrolled in the study. Among them, 108 Malaysians participated. The Jordanians had significantly higher knee laxity in both knees compared with the Malaysians. The mean average right knee laxity for Jordanians was 2.98 mm vs. 2.72 mm for Malaysians (P = 0.005). Similarly, the mean average left knee laxity for Jordanians was 2.95 mm, while for Malaysians, it was 2.62 mm (P = 0.0001). Furthermore, smokers had significantly more laxity in both knees. After performing a multivariate linear regression analysis for all factors, race was the only independent factor that affected knee laxity in both knees.ConclusionsRace is directly associated with knee laxity. Jordanians tend to have more laxity in knee joints compared with Malaysians. Larger multi-center and genetic studies are recommended to establish the racial differences between different ethnic groups.     

高频超声用于急性阑尾炎诊断的临床价值探讨

目的:研究急性阑尾炎诊断中高频超声的应用价值。方法:2018年4月~2019年12月本院接诊的急性阑尾炎病患75例,予以低频和高频超声检查。结果:本组高频超声诊断的准确率比低频超声高,P<0.05。结论:于急性阑尾炎诊断中运用高频超声,可提高诊断准确率。     

Utility of teledermatopathology for intraoperative margin assessment of melanoma in situ,lentigo maligna type: A 6 year community practice experience

BackgroundAchieving negative margins for melanoma in situ, lentigo maligna type can be challenging, particularly on cosmetically sensitive areas.ObjectiveTo assess the utility of intraoperative frozen section margin assessment using a teledermatopathology system in the treatment of head and neck lentigo maligna.Methods and materialsOver a 6 year period, 96 patients with lentigo maligna had surgical excisions. The margins were assessed intraoperatively with frozen sections prepared in the manner used in Mohs surgery. The surgeon guided the frozen section slides around the margin while a dermatopathologist assessed the margin remotely.ResultsIn 2/96 (2.1%) cases, the safety margin was positive (frozen sections were false negative). In 1 further case (1%) there was a recurrence of the melanoma 13 months following the excision.ConclusionThe described method is effective in treating melanoma in situ, lentigo maligna type with clearance rates similar to previous studies for Mohs surgery.     

The chemokine CXCL9 expression is associated with better prognosis for colorectal carcinoma patients

The chemokine CXCL9 has been demonstrated to play an important role in the development of human malignancies. However, its prognostic significance in cancer patients remains unclear and less is known about its role in colonrectal carcinoma (CRC) patients. In this study, we found that the relative mRNA expression level of CXCL9 in primary colorectal tumor tissues was significantly higher than that in corresponding normal colon tissues. CXCL9 protein expression was also detected in 102 of 130 primary CRC patients by immunochemistry. Thus, CXCL9 might play a vital role in the progression of colorectal cancer. By analyzing the correlation between clinicopathological factors of patients and expression of CXCL9 protein, we showed that the expression of CXCL9 was significantly associated with tumor differentiation, tumor invasion, lymph node metastasis, distant metastasis, and vascular invasion, but not with other factors of CRC patients including age, gender, tumor location and tumor size. Furthermore, by performing Kaplan–Meier method as well as Cox’s univariate and multivariate hazard regression model, we found that the higher the CXCL9 expression, the higher overall survival rate was observed, and CXCL9 expression was a significant independent prognostic factor for CRC patients. Therefore, CXCL9 is a useful predictor of better clinical outcome in CRC patients.     

卫生专业技术人员职称评审工作实践及体会

职称评审工作与专业技术人员的切身利益密切相关,也是人事部门的重要工作。对卫生专业技术人员的职称评审,遴选出优秀的专业技术干部,能够有效促进医学院校医、教、研全面发展,进而提高医学院校的整体实力及水平。笔者就职称评审的范围、程序、标准、监督等方面作简单概述,并总结工作经验和体会。