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31.
动态脑电图对癫痫诊断和鉴别诊断的意义 总被引:1,自引:0,他引:1
对临床诊断癫痫的53例和可疑癫痫的117例行24h动态脑电图(AEEG)监测。结果AEEG阳性率(32.9%)明显高于常规EEG(20%),AEEG痫样放电率在癫痫组为54.7%(29/53),可疑癫痫组为15.4%(18/117)。后者中有临床发作者63例,检出痫样放电10例,睡眠期出现痫样放电占89.4%(42/47)。本文对痫样放电出现与临床发作间的关系以及癫痫诊断和鉴别诊断进行了讨论。 相似文献
32.
目的:探究细胞因子TNF-α、IL-6和IL-8在白血病异基因造血干细胞移植后的变化和病情及预后的关系.方法:用放射免疫分析检测了白血病异基因造血干细胞移植患者(48例)、正常健康人(30例)血清TNF-α、IL-6和IL-8水平,对移植后发生或未发生急性移植物抗宿主病(aGVHD)及发生或未发生慢性移植物抗宿主病(cGVHD)进行了比较,并对预后也进行比较.结果:急、慢性GVHD组与未发生急、慢性GVHD组患者的血清TNF-α、IL-6及IL-8水平均高于正常对照组(P<0.05,除未发生cGVHD组的TNF-α浓度低外);急、慢性GVHD组与未发生急、慢性GVHD组比血清TNF-α、IL-6及IL-8水平均升高(P<0.05);移植后死亡组生存时间≤6月及>6月(除>6月的IL-8水平外)各组TNF、IL-6与IL-8水平均高于同期的存活组(P<0.05).结论:异基因造血干细胞移植术后动态监测TNF、IL-6、IL-8水平变化有助于对发生aGVHD 或cGVHD的可能提供另一种检测方法,并对判断愈后有一定的临床意义. 相似文献
33.
Jian Zhang Ai Zhao Shiyun Lai Qingbin Yuan Xiaojiang Jia Peiyu Wang Yumei Zhang 《Nutrients》2021,13(5)
Our knowledge related to human milk proteins is still limited. The present study determined the changes in multiple human milk proteins during the first six months of lactation, investigated the influencing factors of milk proteins, and explored the impact of milk proteins on infant growth. A total of 105 lactating women and their full-term infants from China were prospectively surveyed in this research. Milk samples were collected at 1–5 days, 8–14 days, 1 month, and 6 months postpartum. Concentrations of total protein and α-lactalbumin were measured in all milk samples, and concentrations of lactoferrin, osteopontin, total casein, β-casein, αs−1 casein, and κ-casein were measured in milk from 51 individuals using ultra performance liquid chromatography coupled with mass spectrometry. The concentration of measured proteins in the milk decreased during the first six months of postpartum (p-trend < 0.001). Maternal age, mode of delivery, maternal education, and income impacted the longitudinal changes in milk proteins (p-interaction < 0.05). Concentrations of αs−1 casein in milk were inversely associated with the weight-for-age Z-scores of the infants (1 m: r −0.29, p 0.038; 6 m: r −0.33, p 0.020). In conclusion, the concentration of proteins in milk decreased over the first six months postpartum, potentially influenced by maternal demographic and delivery factors. Milk protein composition may influence infant weights. 相似文献
34.
Oneofthereasonsforfailureofchemotherapyintreatingleukemiaisthattheleukemiccellspresentdrugtolerancetochemotherapeuticagents.Thecur renthotpointofanti leukemicdrugtoleranceresearchismultidrugresistance(MDR).MDRcouldbegen erallydividedaccordingtoitsmech… 相似文献
35.
《中医科学杂志(英文)》2023,10(1):58-63
BackgroundPatients with colon cancer who receive chemotherapy usually experience various gastrointestinal adverse reactions, including nausea, vomiting, and diarrhea, which make it challenging for them to adhere to treatment. As an effective traditional Chinese medicine, the Jianpi Bushen formula has been widely used to alleviate the side effects of chemotherapy.ObjectiveTo evaluate the efficacy and safety of Jianpi Bushen formulae for patients who undergo chemotherapy. This statistical analysis plan (SAP) is intended to enhance the transparency and research quality of our randomized controlled trial.MethodsOur study is a multicenter, double-blind, randomized controlled clinical trial. This trial aimed to compare the completion rate of chemotherapy in colon cancer patients who are using and not using Jianpi Bushen formula. To attenuate possible selection bias in the final report, we declared the overall trial design, outcome measures, subgroup analyses, and safety measures. Also, we described the data management and statistical analysis methods in detail.ConclusionThe SAP provides more detailed information than the trial protocol for data management and statistical analysis methods. Further post-hoc analyses can be performed by referring to the SAP, and possible selection bias can be attenuated. 相似文献
36.
目的系统评价中成药和汤剂治疗肝肾阴虚证绝经后骨质疏松症(postmenopausal osteoporosis,PMOP)的疗效及安全性。方法计算机检索CNKI、CBM、VIP、万方数据库、PubMed、Embase、Cochrane图书馆,检索自建库以来至2019年9月23日的文献,按照纳排标准,收集调补肝肾法治疗PMOP的临床对照试验,依据Cochrane Handbook for Systematic Reviews of Interventions(version 5.35)进行质量评估,并使用RevMan5.3软件进行Meta分析。结果纳入9篇文献,9个研究。与常规治疗的中成药和西药相比,在降低中医证候积分[分别为MD=-3.74,95%CI(-4.86,-2.62),P<0.01;MD=-2.05,95%CI(-2.26,-1.84),P<0.01]、提高血清雌激素[分别为SMD=0.69,95%CI(0.21,1.17),P<0.01;SMD=0.37,95%CI(0.01,0.74),P=0.04]方面,单用调补肝肾法可能优于常规治疗;在临床症状疗效有效率[分别为RR=1.03,95%CI(0.90,1.17),P=0.68;RR=1.24,95%CI(0.94,1.63),P=0.13]、提高腰椎骨密度[分别为MD=0.01,95%CI(-0.03,0.05),P=0.65;MD=0.03,95%CI(-0.01,0.07),P=0.12]指标方面,与常规治疗组相比,无显著性差异。无纳入文献提示单用或联合应用以调补肝肾为治法选用的中成药和汤剂出现不良反应。结论中成药和汤剂在改善肝肾阴虚PMOP患者腰脊疼痛、腰膝酸软无力等的症状及提高血清雌激素方面,具有一定的治疗作用,具有较好的安全性。 相似文献
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39.
Hao Xu Dazhuo Shi Keji Chen Xiaochang M Yongli Li Liang Meng Weimin Yuan 《中国结合医学杂志》2000,6(4):278-282
Objective: To study the effect of Xiongshao capsule (XSC) on vascular remodeling in porcine coronary balloon injury model.Methods: Coronary artery restenosis model was established by oversized balloon injury at mid-region of the left anterior descending
coronary artery. They were divided into 5 groups, untreated or treated with probucol, Xueguantong, low and high dose of XSC
respectively, and compared. The effect of XSC on late lumen loss resulted from vascular remodeling was evaluated by quantitative
histological method with combining histopathological analysis and coronary angiographie examination.Results: The (59 ± 20)% of late lumen loss was caused by vascular remodeling and (41 ± 20)% caused by intimai hyperplasia. Compared
with the control group, all the treatment could significantly reduce the late lumen loss after balloon injury (P<0.05 orP < 0.01 ), both low and high dose of XSC could significantly reduce the late lumen loss caused by remodeling (P<0.05 and P<0.01
respectively).Conclusion: Vascular remodeling plays an important role in late lumen stenosis formation in coronary artery after balloon injury. XSC
could significantly inhibit the pathological vascular remodeling, and thus reduce the late lumen loss and prevent the restenosis
of the injured coronary artery.
Part of a National Ninth-Five Planning Project (No. 96-9060601) 相似文献
40.