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1.
《The journal of sexual medicine》2015,12(3):600-610
IntroductionChronic treatment with phosphodiesterase type 5 inhibitors (PDE5) is effective in an animal model of diabetes‐induced erectile dysfunction (DMED). In addition, recent research indicates that glycemic control can restore DMED.AimsWe evaluated the effect of chronic administration of PDE5 combined with glycemic control on DMED.MethodsSprague‐Dawley rats (8 weeks old) were divided into five groups (n = 10 each): normal control (C), diabetes (DM), DM treated with insulin (DM‐I), DM treated with PDE5 (DM‐P), and DM treated with insulin and PDE5 (DM‐I + P). Rats in the diabetic groups received an injection of streptozotocin (45 mg/kg). After 10 weeks of induced diabetes, the DM‐I group was treated with a daily injection of neutral protamine Hagedorn, and the DM‐P group was treated with a daily dosage of 20 mg/kg PDE5 (DA‐8159) for 4 weeks. The DM‐I + P group was treated with both treatments simultaneously. After 14 weeks of induced diabetes, an evaluation of erectile function and histological and biochemical markers of corporal tissue was performed.Main Outcome MeasuresErectile function and histological and biochemical markers in corporal tissue.ResultsRats in the DM group showed markedly lower erectile parameters than those in the C group, whereas rats in the DM‐I and DM‐P groups showed intermediate erectile function between the DM and C groups. Rats in the DM‐I + P group showed restored erectile function, comparable with group C. A comparison of apoptotic index, expression of the endothelial marker, and phosphorylation of endothelial nitric oxide synthase and Akt displayed a similar pattern with the results from cavernosometry (DM < DM‐I = DM‐P < DM‐I + P = C, P < 0.05). The distribution of phosphorylated myosin phosphatase target subunit 1 was in the reverse order.ConclusionsChronic administration of PDE5 or glycemic control with insulin resulted in restoration of overt DMED. The combination of both treatments was superior to monotherapy with insulin or PDE5. Choi WS, Kwon OS, Cho SY, Paick J‐S, and Kim SW. Effect of chronic administration of PDE5 combined with glycemic control on erectile function in streptozotocin‐induced diabetic rats. J Sex Med 2015;12:600–610. 相似文献
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异丙酚静脉麻醉在食管贲门狭窄扩张治疗中的应用研究 总被引:1,自引:0,他引:1
目的 研究应用异丙酚静脉麻醉在食管贲门狭窄扩张治疗中的可行性和安全性。方法 将食管狭窄病人 80例随机分为观察组 (A组 ) 40例和对照组 (B组 ) 40例 ,观察组给予异丙酚静脉麻醉后再行扩张等治疗 ,对照组则不予静脉麻醉而行常规操作 ,比较两组扩张治疗中病人的反应和感受、操作时间及观察组在治疗前、中、后血压、心率和血氧饱和度的变化。结果 观察组病人满意度 95% ,而对照组为 18% (P <0 0 1) ,观察组病人流涎、恶心呕吐和躁动的发生率明显低于对照组 (P <0 0 1) ,观察组平均操作时间相对较短 ,心率、血压 (收缩压和舒张压 )、血氧饱和度治疗前、中、后无明显差别。结论 在食管贲门狭窄扩张治疗中应用异丙酚静脉麻醉是安全有效的 ,且可缩短操作时间 ,减少不良反应 ,提高病人的依从性 相似文献
3.
为探讨肾动脉瘤(RAA)的特点和诊治方法,回顾性分析2015年6月-2019年10月我院收治的14例RAA患者的临床资料.14例患者中,男8例,女6例;年龄40~77岁,平均59.1岁;左肾RAA 6例,右肾RAA 7例,双肾RAA 1例;体检发现8例,表现为腰腹部疼痛5例,表现为血压骤升1例;2例RAA破裂,1例表现... 相似文献
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已经有越来越多的证据表明基因组的非编码序列的转录对于生命活动具有重要意义。相对于蛋白编码序列以及各种小分子RNA,长链非编码RNA(lncRNA)的研究还仅仅处于起步阶段,其功能与调控机制仍有待进一步研究。本文对目前关于lncRNA与肿瘤关系的研究进展进行综述,认为lncRNA可能为肿瘤诊断和治疗提供新依据和靶点。 相似文献
6.
Background
Deferoxamine mesylate is known to ameliorate tissue ischemia-reperfusion injury. This study was designed to explore the impact of deferoxamine mesylate preconditioning (DMP) on pancreatic tissue and its possible effects during orthotopic liver autotransplantation.Methods
A modified orthotopic liver autotransplantation model was used to simulate pancreatic ischemia-reperfusion injury. Sprague-Dawley rats (0.25-0.30 kg) were randomly divided into normal control, autotransplantation (AT), systemic deferoxamine mesylate preconditioning (SDMP), and partial deferoxamine mesylate conditioning (PDMC) groups. The SDMP group was injected with deferoxamine mesylate (75-90 mg; 300 mg/kg), via the celiac artery at 24 and 48 hours before surgery. During surgery, the PDMC group underwent liver perfusion by means of deferoxamine mesylate solution (20 ml; 0.6 mmol/L) rather than Ringer's lactate solution, with no prior preconditioning. At 6, 24, and 48 hours after surgery, the rats were sacrificed to sample their pancreatic tissues for the expression of hypoxia-inducible factor-1α (HIF-1α) and malondialdehyde (MDA) content. The samples were subjected to blood chemistry analyses, light and transmission electron microscopic morphological studies, and quantitative measurement of HIF-1α expression.Results
The serum levels of amylase, lipase, and MDA in SDMP and PDMC groups were significantly lower than those in the AT group at 6, 24, and 48 hours after orthotopic liver autotransplantation (P < .05). Light and electron microscopic analyses showed much more severe pancreatic injury in the autotransplantation than in the SDMP and PDMC groups. The HIF-1α expression was increased in the SDMP and PDMC groups more than in the autotransplantation group (P < .05).Conclusions
Deferoxamine mesylate preconditioning protected pancreatic tissue in orthotopic liver autotransplantation in rats. Inhibition of oxidative toxic reactions and up-regulated expression of HIF-1α protein are possible mechanisms. 相似文献7.
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目的探讨游离髂腹股沟皮瓣修复足外伤软组织缺损的临床效果。方法应用游离髂腹股沟皮瓣修复足外伤软组织缺损12例,缺损面积:6cm×13cm-10cm×20cm,平均8cm×16cm,其中软组织感染5例。入院清创、骨折内固定,感染病例先行负压封闭引流(VSD)治疗1周,待感染控制后切取皮瓣修复创面。结果12例皮瓣全部成活.创面一期愈合,随访3个月~1年,疗效满意,皮瓣质地柔软,外观臃肿不明显,供区愈合良好,仅留有线状瘢痕。根据下肢负重是否疼痛、关节活动度及恢复工作等指标评价下肢肢体功能.优良率为85%。结论足外伤软组织缺损行游离腹股沟皮瓣修复可获得较满意疗效。 相似文献