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1.
IntroductionAnti-thymocyte globulin (ATG) is used prior to allogeneic hematopoietic stem cell transplantation (allo-HSCT) for graft-versus-host disease (GVHD) prophylaxis. Two different ATG doses (7.5 or 10 mg/kg) were evaluated in comparison with a group without ATG therapy.MethodsWe retrospectively analyzed 132 patients who were transplanted with HSCT without ATG (non-ATG), or who received 7.5 mg/kg ATG (ATG-7.5) or 10 mg/kg ATG (ATG-10) prior to transplantation. The immune cells (CD3+CD4+ T cells, CD3+CD8+ T cells, CD19+ B cells and CD16+CD56+ NK cells) were examined in peripheral blood every three months post-HSCT for 12 months.ResultsCompared with non-ATG group, combined ATG-7.5/ATG-10 groups had significantly lower CD3+CD4+ T cells and higher CD3+CD8+ T cells at 3, 6, 9, 12 months post-HSCT; thus, displaying a lower CD4/CD8 ratio in the ATG groups compared to non-ATG group. The ratio of CD19+ B cells was statistically lower (at 3rd month, p = .014; at 6th month, p = .025) in combined ATG-7.5/ATG-10 groups at 3 and 6 months post-HSCT, but not at 9 and 12 months after HSCT. The ratios of CD3+CD4+ T cells, CD3+CD8+ T cells, CD19+ B cells and CD16+CD56+ NK cells were similar between the ATG-7.5 and ATG-10 groups at all examined time points. The overall survival (OS), progression-free survival (PFS), relapse and acute GVHD (aGVHD) were comparable among recipients without ATG therapy and with ATG-7.5 or/and ATG-10 therapies. Multivariate analysis revealed that immune cells ratios were not independent factors affecting prognosis.ConclusionThe ATG therapy at higher and lower doses led to a delayed reconstitution of T cells and the inversion of CD4/CD8 ratio for at least one year after HSCT. 相似文献
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Merkel细胞癌是一种罕见的、具有高度侵袭性的皮肤神经内分泌癌,好发于老年人的日光暴露部位,尤其是头颈部(41%~50%),其次是四肢(32%~38%)。Merkel细胞癌可与鳞状细胞癌、鲍温病、基底细胞癌等皮肤肿瘤合并发生。我们报道一例发生在非光暴露部位的Merkel细胞癌合并原位鳞状细胞癌,并对相关文献进行复习。 相似文献
3.
患者,男,41岁。双手指先后出现单个淡黄色丘疹、斑块半年,组织病理见泡沫细胞团块状浸润,免疫组化示泡沫样组织细胞CD68(+)、S100(-),查血血脂升高。诊断结节性黄瘤病。经规范降脂治疗,8个月随访未复发。 相似文献
4.
患者,男,67岁。鼻部增生性斑块4个月,有外伤史。实验室检查:组织病理可见真菌孢子,真菌镜检可见硬壳小体,真菌培养与菌种鉴定为卡氏枝孢瓶霉。予伊曲康唑、热敷治疗,患者治疗第1个月后原皮损部位出现的增生性皮疹,继续原治疗方案3个月,增生性皮疹萎缩,基本痊愈。出现增生性皮疹的原因猜测为伊曲康唑治疗后,皮损部位的真菌细胞膜功能受损,大量异种蛋白被机体识别,加重了局部的炎症反应,具体原因还需要进一步研究。 相似文献
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BackgroundEarly recurrence (ER) after radical resection of hepatocellular carcinoma (HCC) affects the prognosis of patients. Gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) can improve the detection rate of small HCC. This study innovatively introduces a new quantitative index combined with qualitative index to compare the differences in clinical and imaging characteristics between ER and non-ER groups and evaluate the feasibility of Gd-EOB-DTPA-enhanced MRI in predicting ER.MethodsA total of 68 patients with HCC confirmed by operation and pathology in the Shandong Cancer Hospital and Institute were included retrospectively. All participants were examined by Gd-EOB-DTPA-enhanced MRI within 3 weeks before surgery. Regular follow-up was performed every 2 months within 1 year after operation. Among them, 18 cases with new lesions were in ER group, and 50 cases without new lesions were in non-ER group. The clinical and imaging data of the 2 groups were collected, and the differences of clinical data and preoperative MRI signs between the ER group and non-ER group were compared. The predictive factors of ER after HCC were analyzed by multivariate logistic regression.ResultsThe quantitative parameter lesion-to-liver contrast enhancement ratio (LLCER) can predict the pathological grade of HCC (P=0.023). The results of univariate analysis between the ER group and non-ER group showed that there were significant differences in pathological grade (P=0.008), lesion morphology (P=0.011), peritumoral low signal intensity in hepatobiliary phase (HBP) (P<0.001), satellite nodules (P<0.001), and LLCER (P<0.001) between the 2 groups. Multivariate logistic regression analysis showed that HBP peritumoral low signal intensity [odds ratio (OR) =7.214, 95% confidence interval (CI): 1.230–42.312, P=0.029], satellite nodules (OR =9.198, 95% CI: 1.402–60.339, P=0.021), and parameter LLCER value (OR =0.906, 95% CI: 0.826–0.995, P=0.039) were independent predictors of ER of HCC after resection.ConclusionsPreoperative Gd-EOB-DTPA enhanced MRI has important predictive value for early recurrence after radical resection of hepatocellular carcinoma. 相似文献
8.
目的:探讨TFPI-2基因在胃癌组织中的表达及其临床意义。方法:收集临床胃癌患者术后大体标本64例,采用免疫组织化学方法检测TFPI-2蛋白在胃癌组织和正常胃黏膜组织中的表达,采用RT-PCR法检测TFPI-2 mRNA在胃癌组织和正常胃黏膜组织中的表达。结果:TFPI-2蛋白在正常胃黏膜组织中的表达高于胃癌组织(P0.05),无淋巴结转移胃癌组织的TFPI-2蛋白表达高于有淋巴结转移的胃癌组织(P0.05)。TFPI-2 mRNA在正常胃黏膜组织中的表达明显高于胃癌组织(P0.05),无淋巴结转移胃癌组织的TFPI-2 mRNA表达高于有淋巴结转移的胃癌组织(P0.05)。结论:TPFI-2基因是胃癌发生、侵袭和转移的重要调节因子,其低表达与胃癌淋巴结转移的生物学行为密切相关。 相似文献
9.
《Biomedical and environmental sciences : BES》2019,32(12):914-921
ObjectiveIncreased carotid artery intima-media thickness (CIMT) and carotid plaque as manifestations of carotid atherosclerosis have been used as markers of cardiovascular disease (CVD). The components of metabolic syndrome (MetS) are linked to CVD, but the association between MetS and CVD is controversial.MethodsA total of 8,933 Chinese adults aged 40 years or older from 2010 to 2014 were selected from the Jidong and Kailuan communities. MetS was defined by the International Diabetes Federation criteria. CIMT and carotid plaque were measured using color Doppler ultrasound. Logistic regression models were used to assess the association of MetS with carotid plaque and CIMT.ResultsMetS was found among 3,461 (3,461/8,933) participants. The odds ratio and 95% confidence internal (CI) for carotid plaques in participants with MetS was 1.16 (1.03–1.30). The risk of carotid plaques increased with the number of MetS components. The average CIMT was higher in participants with MetS (β = 0.020, 95% CI, 0.014–0.027) and in participants with more MetS components.ConclusionIndividuals with MetS are at an increased risk for carotid atherosclerosis compared to those without MetS. 相似文献
10.
目的 探讨老年人颈动脉狭窄与脑白质结构网络拓扑属性之间的关系。方法 选取济南地区颈动脉狭窄老年人101例为研究对象,根据北美症状性颈动脉内膜切除试验法(NASCET)分为轻(n=35)、中(n=34)、重度狭窄(n=32)组。采用确定性纤维追踪技术构建研究对象的脑白质结构网络;基于图论分析方法研究轻、中、重度狭窄组的脑白质结构网络拓扑属性之间的差异;运用多元线性回归分析颈动脉狭窄程度与脑白质结构网络拓扑属性之间的关系。结果 重度狭窄组局部效率(Eloc)低于轻、中度狭窄组(P均<0.001),其最短路径长度(Lp)大于轻、中度狭窄组(P<0.001,P=0.016);中、重度狭窄组的聚类系数(Cp)低于轻度狭窄组(P=0.009,P<0.001);重度狭窄组的小世界属性(σ)低于轻度狭窄组(P=0.01)。多元线性回归分析结果显示,颈动脉狭窄程度分别与Eloc、Cp、σ呈负相关(Eloc:中度狭窄组β=-0.026,P=0.002,重度狭窄组β=-0.060,P<0.001;Cp:中度狭窄组β=-0.018,P=0.007,重度狭窄组β=-0.031,P<... 相似文献