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《The journal of sexual medicine》2015,12(3):720-727
IntroductionTreatment satisfaction of men receiving phosphodiesterase 5 inhibitors (PDE5) for erectile dysfunction (ED) and their partners is essential to successful long‐term therapy.AimThis study aims to assess treatment satisfaction, in men with a partial response to on‐demand (PRN) PDE5 and their female partners, following tadalafil 5 mg once daily or placebo.MethodsThe study was randomized, double‐blind, parallel, and placebo‐controlled in men primarily with mild to moderate ED. Treatment satisfaction was assessed following a 4‐week maximum dose PRN lead‐in, 4‐week nondrug washout, and treatment through 12 weeks. Men were ≥18 years old with ED for ≥3 months and International Index of Erectile Function Erectile Function score of ≥17 and <26 at screening and <26 following PRN lead‐in.Main Outcome MeasuresTreatment satisfaction was assessed using the Treatment Satisfaction Scale (TSS) for patients and partners. TSS domain scores range from 0 to 100, with higher values indicating greater satisfaction. Statistical comparisons were made using analysis of covariance.ResultsTreatment satisfaction was significantly greater with tadalafil once daily vs. placebo across all TSS domains for both patients and their partners (all P < 0.001). For patients, mean scores for the TSS domains Confidence to Complete Sexual Activity and Satisfaction with Orgasm ranged from 53.7 to 57.8 after the PRN lead‐in and 26.7 to 31.9 following the nondrug washout. Following randomized treatment, scores for tadalafil and placebo were 55.4 and 32.6, respectively, for Confidence to Complete Sexual Activity and 57.5 and 37.9, respectively, for Satisfaction with Orgasm. Results were comparable for other TSS domains and between men and their partners.ConclusionsTreatment satisfaction was comparable for tadalafil 5 mg once daily and PRN PDE5 for both patients and female partners, suggesting that tadalafil once daily is a viable therapy option for men with ED who had a partial response to PRN PDE5 therapy. Burns PR, Rosen RC, Dunn M, Baygani SK, and Perelman MA. Treatment satisfaction of men and partners following switch from on‐demand phosphodiesterase type 5 inhibitor therapy to tadalafil 5 mg once daily. J Sex Med 2015;12:720–727. 相似文献
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《European Journal of Radiology Extra》2007,61(1):15-18
Alveolar soft part sarcoma is a rare malignancy mainly localized in the deep soft tissue of the extremities. This is the first report of an alveolar soft part sarcoma originating from the sphincter ani externus. A 27-year-old pregnant woman presented with a tumour located in the right ischiorectal fossa which had rapidly enlarged during pregnancy 6 years after first detection. Admitted to our hospital, she presented with a continuous strong vaginal bleeding, multiple pulmonal metastases and an inoperable local tumour mass. Palliative chemotherapy was unsuccessful, control of local bleeding was only possible with multiple embolisations. The patient died 43 months after initial diagnosis. Our intention is to point out the remarkable origin, a rapid tumour growth during pregnancy, and the possibility of controlling massive tumour bleeding by embolisation. 相似文献
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《IBS, Immuno》2005,20(6):360-371
Influence of maternal smoking on newborn's behaviour: determination urinary nicotine metabolites levels in mothers and infants.Objective. – Effects of smoking during pregnancy on newborn's behaviour at 2 or 3 days. Intoxication? Withdrawal?Population and method. – Urinary cotinine levels were measured using DPC® technique in 142 mothers during labour and in their 138 normal, full-term newborns kept with their mothers at about 3 days. Infants' Finnegan scores were estimated, Lamour/Barraco tests, too.Results. – There are significant correlations: maternal cotinine (ng/mg) = 382,67 + 264,79 cigarettes/day, R = 0,70, P < 0,001; newborn cotinine (ng/mg) = 74,28 + 68,49 cigarettes/day, R = 0,69, P < 0,001; newborn cotinine (ng/mg) = 57,59 + 0,18 maternal cotinine (ng/mg), R = 0,73, P < 0,001. Newborns' cotinine concentrations (47% corresponds with smokers' levels) are with breast-milk 4,94 times lower than that of their mothers vs 3,65 with artificial milk. Incidence of colic increases (P = 0,008) and the neurologic scores average decreases (P = 0,059).Conclusions. – Newborns' high cotinine levels, digestive and neurologic symptoms modification suggest tobacco intoxication. Therefore withdrawal would appear later. Breast-milk seems to accelerate cotinine elimination. 相似文献
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《Anaesthesia and Intensive Care Medicine》2007,8(5):194-199
Epidural blockade in children has become more popular for postoperative analgesia in recent years owing to increased experience, greater confidence and the development of appropriate equipment. In the UK, approximately 2000 lumbar epidural and continuous caudal blocks are performed each year. Spinal anaesthesia remains popular for babies at risk of postoperative apnoea, but is being superseded by light general anaesthesia with desflurane or sevoflurane combined with caudal blockade. Contraindications to neuraxial blockade include patient or parental refusal, coagulation abnormalities, septicaemia, raised intracranial pressure, meningitis, infection at the entry site, allergy to local anaesthetics, myelomeningocele (spina bifida) and abnormal sacral anatomy for a caudal epidural. 相似文献
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