Genetic characterization of 19 X-STRs in Sierra Leone population from Freetown

International Journal of Legal Medicine - A total of 550 individuals (265 males and 285 females) from Sierra Leone, a west-African coastal country, were genotyped using the Microreader™ 19X...     

Forensic parameters and genetic structure analysis of 30 autosomal InDels of the population in Freetown,Sierra Leone

International Journal of Legal Medicine - As the origin of modern humanity, African populations show high genetic diversity and are attracting increasing academic attention. However, populations...     

Serum hepatitis B surface antigen correlates with fibrosis and necroinflammation: A multicentre perspective in China

The kinetics of serum hepatitis B surface antigen (HBsAg) during the natural history of hepatitis B virus (HBV) infection has been studied, but the factors affecting them remain unclear. We aimed to investigate the factors affecting HBsAg titres, using data from multicentre, large‐sized clinical trials in China. The baseline data of 1795 patients in 3 multicentre trials were studied, and the patients were classified into 3 groups: hepatitis B early antigen (HBeAg)‐positive chronic HBV infection (n = 588), HBeAg‐positive chronic hepatitis B (n = 596), and HBeAg‐negative chronic hepatitis B (n = 611). HBsAg titres in the different phases were compared, and multiple linear progression analyses were performed to investigate the implicated factors. HBsAg titres varied significantly in different phases (P = .000), with the highest (4.60 log10 IU/mL [10%‐90% confidence interval: 3.52 log10 IU/mL‐4.99 log10 IU/mL]) in patients with HBeAg‐positive chronic HBV infection. In all phases, age and HBV DNA were correlated with serum HBsAg level. In HBeAg‐positive chronic hepatitis B patients, a negative correlation between HBsAg titres and fibrosis stage was observed. Alanine amonitransferase or necroinflammatory activity was also correlated with HBsAg titres in HBeAg‐negative chronic hepatitis B patients. In conclusion, decreased HBsAg titres may be associated with advancing fibrosis in HBeAg‐positive chronic hepatitis B patients or increased necroinflammation in those with HBeAg‐negative chronic hepatitis B. Our findings may help clinicians better understand the kinetics of HBsAg and provide useful insights into the management of this disease.     

Walking characteristics of runners with a transfemoral or knee-disarticulation prosthesis

BackgroundRunning with prostheses has become a common activity for amputees participating in sports and recreation. However, very few studies have characterized the kinematic and kinetic parameters of walking in individuals with amputation who are runners. Thus, this study attempts to elucidate the kinematics and kinetics of walking in runners with a unilateral transfemoral amputation or knee-disarticulation.MethodsThis study experimentally compares the prosthetic and intact limbs of runners with prostheses as well as compares the findings against the limbs of age-matched able-bodied individuals while walking. Fourteen runners with a unilateral transfemoral amputation or knee-disarticulation were recruited and 14 age-matched able-bodied individuals were prepared using gait database. Spatiotemporal, kinematic, and kinetic parameters of walking were analyzed using a 3-demensional motion capture system.ResultsThe results showed that the peak ankle positive power at pre-swing and peak hip positive power from loading response to mid stance in the intact limb were significantly larger than that in the prosthetic limb. Moreover, to compensate for missing anatomical functions on the prosthetic limb, it appeared that the intact limb of the runners generated larger peak joint power by producing more ankle plantarflexor and hip extensor moments while walking.InterpretationThis study demonstrated that the runners rely on their intact limb while walking. Training of hip extensor muscles of the intact limb may be beneficial for these individuals.     

Association between CD95L polymorphism and cervical cancer risk: evidence from a meta-analysis

Several studies have assessed the association of CD95L polymorphism with cervical cancer risk, but the data lack the power to provide compelling evidence. In this study, we aimed to clarify the association through a meta-analysis. A comprehensive search was conducted in PubMed, Embase, and Web of Science. The fixed-effects model was used to calculate odds ratio (OR) with 95 % confidence intervals (CIs). A total of five papers with six case–control studies were derived and finally included in this meta-analysis. The overall estimate did not reveal any significant association between CD95L ?844C/T polymorphism and cervical cancer risk. Subgroup analysis in Asian population indicated nonsignificant nevertheless potentially increased risk in CC genotype carriers in comparison with the carriers of CT?+?TT genotypes (OR_{CC vs. CT?+?TT}?=?1.16, 95 % CI?=?0.99–1.36, P for heterogeneity?=?0.231). Based on current epidemiological studies, this meta-analysis suggests that CD95L polymorphism may not be a risk factor contributing to cervical cancer development.