一种新的T波终点定义方法及其在QT间期检测中的应用

T波终点识别是ECG信号QT间期检测中的关键技术。由于T波末端呈对数衰减及易受杂音叠加的影响,使得高精度的T波终点识别显得困难。定义T波末端衰减率至某一阈值δ的时刻为T波终点,并将此法应用于QT间期的自动检测。以T波顶点为标识,将其后的0.2 s数据叠加成一个平均信号φ(t),以函数φ^(t)=Aeαt拟合φ的末端,并利用最小二乘法确定其参数。将此φ函数作为模板去匹配心电图的T波可获得相应的A和α值,并通过微分运算得出T波终点的位置。利用此方法进行QT间期检测,显示出良好的准确性和鲁棒性。     

A new cytosolic DNA-recognition pathway for DNA-induce~ inflammatory responses

Innate recognition of DNA within intracellular compartments or thecytoplasm leads to activation of the immune system, which can result in defense against DNA virus infections or the initiation of pathological responses to self-DNA. In the past several years, the field of DNA sensing has undergone an immense expansion. Many DNA sen- sors have been proposed, including cGAMP synthase （cGAS）, DNA-depen- dent activator of interferon （IFN）-regula- tory factors （also named Z-DNA binding protein 1）, absent in melanoma 2 （MM2）, leucine-rich repeat （in Flightless I） inter- acting protein-1, DExD/H box helicases （DHX9 and DHX36） and IFN-inducible protein IFI16^1-3 （Figure 1）.     

AQP1和AQP5在原发性输卵管癌中的表达及临床意义

目的:探讨水通道蛋白AQP1和AQP5在原发性输卵管癌中的表达及临床意义。方法:采用免疫组织化学法检测37例原发性输卵管癌、15例正常输卵管组织AQP1和AQP5的表达。结果:AQP1主要表达在原发性输卵管癌癌巢周围间质毛细血管和微血管的内皮细胞上,AQP5表达于癌细胞质内及输卵管上皮细胞质。AQP1和AQP5在原发性输卵管癌中呈高表达,与正常输卵管AQP1和AQP5比较有统计学差异(P<0.001),Ⅲ,Ⅳ期输卵管癌AQP1的表达明显高于Ⅰ、Ⅱ期(P<0.01),但在组织学分级及淋巴转移间无统计学差异。AQP5的表达在不同组织学分级、临床分期及淋巴转移间无统计学差异。结论:AQP1和AQP5的高表达可能与原发性输卵管癌的发生、发展有密切关系。     

养血当归胶囊治疗功能性痛经临床疗效观察

目的:探讨养血当归胶囊治疗功能性痛经的临床疗效。方法:经本院确诊功能性痛经患者191例,随机分为两组,治疗组112例,对照组79例,两组患者年龄、病程、病情均无统计学差异(P>0.05)。对照组:于经前7d口服布洛芬胶囊,一次300mg,一天2次,15d为一疗程,连续服用两个月经周期;治疗组:于经前7d口服养血当归胶囊,一次3粒,一天3次,15d为一疗程,连续服用两个月经周期。结果:治疗组112例患者,服用两个疗程后,治愈15例,显效48例,有效33例,总有效率达到85.7%,治愈率13.4%,不良反应1例,不良反应发生率0.89%;对照组79例患者,服用两个疗程后,治愈1例,显效19例,有效45例,总有效率82.3%,治愈率1.3%,不良反应9例,不良反应发生率12.6%。两组比较,总有效率无统计学差异(P>0.05);治愈率治疗组明显高于对照组,有统计学差异(P<0.01);不良反应发生率治疗组明显低于对照组,有统计学差异(P<0.01)。结论:养血胶囊治疗功能性痛经疗效显著,治愈率高,副作用少,值得临床推广使用。     

Analysis of related factors affecting prognosis of shunt surgery in patients with secondary normal pressure hy- drocephalus

Objective： The management of se- condary normal pressure hydrocephalus （sNPH） is controversial. Many factors may affect the surgery effect. The purpose of this study was to identify the possible fac- tors influencing prognosis and provide theoretical basis for clinical treatment of sNPH. Methods： A retrospective study was carried out to investigate the results of 31 patients with sNPH who under- went ventriculoperitoneal shunt surgery from January 2007 to December 2011. We processed the potential influencing factors by univariate analysis and the result further by mul- tivariate logistic regression analysis. Results： Factors including age, disease duration and Glasgow coma scale （GCS） score before surgery significantly influenced the prognosis of sNPH （P〈0.05）. Further logistic regression analysis showed that all the three factors are independent influencing factors. Conclusion： Age, disease duration and GCS score before surgery have positive predictive value in estimating favorable response to surgical treatment for sNPH.