低剂量电子计算机断层扫描对疑似急性下呼吸道感染老年患者的临床诊断价值及安全性

目的研究低剂量电子计算机断层扫描（CT）对疑似急性下呼吸道感染老年患者的临床诊断价值及其安全性。 方法收集2016年9月至2018年8月广州中医药大学深圳医院（福田）收治的92例疑似急性下呼吸道感染老年患者为研究对象，按随机数字表法分为观察组和对照组，每组各46例。其中对照组患者采用常规剂量CT扫描；观察组患者采用低剂量CT扫描。比较两组患者的诊断效能及辐射剂量，分析低剂量CT对急性下呼吸道感染者的诊断价值。 结果对照组和观察组患者CT检查对急性下呼吸道感染的阳性检出率分别为86.96%和82.61%，差异无统计学意义（χ² = 0.733、P = 0.392）。两组患者CT检查对急性下呼吸道感染诊断的灵敏度、特异度、阳性预测值以及阴性预测值差异均无统计学意义（P均> 0.05）。观察组患者平均辐射剂量为（1.28 ± 0.26）mSv，显著低于对照组[（3.12 ± 0.36）mSv]，差异有统计学意义（t = 28.102、P < 0.001）。 结论低剂量CT对疑似急性下呼吸道感染老年患者诊断价值与常规剂量CT检查相似，且辐射剂量小、安全性高。     

敲低BTF3基因表达对膀胱癌细胞T24生物学功能的影响

目的:探究BTF3基因对人膀胱癌细胞株T24生物学功能的影响。方法:通过慢病毒感染的方法，构建BTF3基因低表达的T24细胞株。通过体外平板克隆实验检测克隆形成，MTT检测细胞增殖，流式细胞术检测细胞凋亡。结果:RT-PCR和Western blotting证实BTF3低表达的T24细胞株构建成功。与对照组的细胞相比，敲低BTF3的表达能够抑制T24细胞克隆形成和细胞增殖，促进细胞凋亡。结论:我们的研究结果证明了BTF3在人膀胱癌细胞株T24中的重要性，提示BTF3不仅可能与膀胱癌的发生有关，而且可能成为膀胱癌潜在的治疗靶点和生物标记物。     

温针灸脾胃经治疗亚健康的疗效观察

〔摘 要〕 目的：探讨温针灸脾胃经治疗亚健康的疗效。 方法：选取深圳宝兴医院 2012–2018 年收治的 131 例亚健康患者， 随机分为观察组（66 例）和对照组（65 例）。观察组选取主穴：双足三里、上巨虚、下巨虚、阴陵泉，配合三阴交及气海 穴，并用温针灸脾胃经的方法；对照组口服谷维素，两组均治疗 4 个疗程，观察每个疗程治疗后的疗效。 结果：两组患者 第１疗程治愈率与有效率比较，差异无统计学意义（P ＞ 0.05）。第 2、3、4 疗程比较，观察组优于对照组，差异具有统 计学意义（P ＜ 0.05）。观察组组内不同疗程比较，治愈率有不同程度上升，差异具有统计学意义（P ＜ 0.05）。 结论：用温针灸脾胃经方法治疗脾胃阳虚型亚健康有效，治疗次数越多，效果越佳。     

冠状静脉向动脉转化的研究进展

冠状动脉粥样硬化性心脏病(CHD)病理特征为不稳定粥样硬化斑块破裂或糜烂基础上血小板聚集、并发血栓形成、冠状动脉痉挛收缩、微血管栓塞导致急性或亚急性心肌供氧的减少和缺血加重,有研究表明冠状静脉可向冠状动脉转化。本文综述了血管生成的分类、冠状静脉向动脉转化的过程、冠状静脉向动脉转化的临床意义和潜在治疗靶点的探索,为今后冠状动脉再生提供治疗依据。     

Characterizing the propagation pathway of neuropathological events of Alzheimer's disease using harmonic wavelet analysis

Empirical imaging biomarkers such as the level of the regional pathological burden are widely used to measure the risk of developing neurodegenerative diseases such as Alzheimer's disease (AD). However, ample evidence shows that the brain network (wirings of white matter fibers) plays a vital role in the progression of AD, where neuropathological burdens often propagate across the brain network in a prion-like manner. In this context, characterizing the spreading pathway of AD-related neuropathological events sheds new light on understanding the heterogeneity of pathophysiological mechanisms in AD. In this work, we propose a manifold-based harmonic network analysis approach to explore a novel imaging biomarker in the form of the AD propagation pattern, which eventually allows us to identify the AD-related spreading pathways of neuropathological events throughout the brain. The backbone of this new imaging biomarker is a set of region-adaptive harmonic wavelets that represent the common network topology across individuals. We conceptualize that the individual's brain network and its associated pathology pattern form a unique system, which vibrates as do all natural objects in the universe. Thus, we can computationally excite such a brain system using selected harmonic wavelets that match the system's resonance frequency, where the resulting oscillatory wave manifests the system-level propagation pattern of neuropathological events across the brain network. We evaluate the statistical power of our harmonic network analysis approach on large-scale neuroimaging data from ADNI. Compared with the other empirical biomarkers, our harmonic wavelets not only yield a new imaging biomarker to potentially predict the cognitive decline in the early stage but also offer a new window to capture the in-vivo spreading pathways of neuropathological burden with a rigorous mathematics insight.     

Autophagy-regulating miRNAs: potential targets for obesity and related metabolic disorders

1. Download : Download high-res image (137KB)
2. Download : Download full-size image

     

简化生物功能性义齿修复牙列缺失的临床效果评价

  目的  评价使用简化生物功能性义齿（simplified biofunctional prosthetic denture，SBPD）修复牙列缺失的疗效及患者满意度。  方法  收集深圳大学总医院牙列缺失拟行全口义齿修复的患者26例，随机分为两组，分别采用传统全口义齿（conventional complete denture，CCD）修复方法（n = 13）和SBPD修复方法（n = 13）制作全口义齿，于戴牙后即刻、戴牙后1个月和戴牙后3个月填写义齿满意度视觉模拟评分量表（Visual analogue scale，VAS）进行满意度调查。  结果  戴牙后即刻、戴牙后1个月和戴牙后3个月，在咀嚼功能、舒适性及固位功能方面应用SBPD修复方法制作的全口义齿满意度显著高于CCD方法制作的全口义齿（P < 0.05）。  结论  应用SBPD修复方法制作全口义齿能够取得比较好的临床效果，值得进一步实践和推广。     

Efficacy and safety of endoscopic resection in treatment of small gastric stromal tumors: A state-of-the-art review

Gastrointestinal stromal tumors can occur in any part of the gastrointestinal tract, but gastric stromal tumors (GSTs) are the most common. All GSTs have the potential to become malignant, and these can be divided into four different grades by risk from low to high: Very low risk, low risk, medium risk, and high risk. Current guidelines all recommend early complete excision of GSTs larger than 2 cm in diameter. However, it is not clear whether small GSTs (sGSTs, i.e., those smaller than 2 cm in diameter) should be treated as early as possible. The National Comprehensive Cancer Network recommends that endoscopic ultrasonography-guided (EUS-guided) fine-needle aspiration biopsy and imaging (computed tomography or magnetic-resonance imaging) be used to assess cancer risk for sGSTs detected by gastroscopy to determine treatment. When EUS indicates a higher risk of tumor, surgical resection is recommended. There are some questions on whether sGSTs also require early treatment. Many studies have shown that endoscopic treatment of GSTs with diameters of 2-5 cm is very effective. We here address whether endoscopic therapy is also suitable for sGSTs. In this paper, we try to explain three questions: (1) Does sGST require treatment? (2) Is digestive endoscopy a safe and effective means of treating sGST? and (3) When sGSTs are at different sites and depths, which endoscopic treatment method is more suitable?     

颌骨及上颌窦Burkitt淋巴瘤1例报告及文献复习

Burkitt淋巴瘤也称为非洲淋巴瘤,多发于非洲儿童。本文报告1例发生于双侧下颌骨及左侧上颌骨及上颌窦的Burkitt淋巴瘤,并结合相关文献,对该病的发病因素、临床特征、诊断和鉴别诊断、治疗原则及预后等进行讨论。