全文获取类型
收费全文 | 23594篇 |
免费 | 1439篇 |
国内免费 | 180篇 |
专业分类
耳鼻咽喉 | 74篇 |
儿科学 | 698篇 |
妇产科学 | 637篇 |
基础医学 | 2005篇 |
口腔科学 | 147篇 |
临床医学 | 2280篇 |
内科学 | 11016篇 |
皮肤病学 | 129篇 |
神经病学 | 796篇 |
特种医学 | 287篇 |
外科学 | 3151篇 |
综合类 | 774篇 |
现状与发展 | 3篇 |
一般理论 | 2篇 |
预防医学 | 1537篇 |
眼科学 | 142篇 |
药学 | 857篇 |
4篇 | |
中国医学 | 61篇 |
肿瘤学 | 613篇 |
出版年
2024年 | 32篇 |
2023年 | 902篇 |
2022年 | 1261篇 |
2021年 | 1603篇 |
2020年 | 1255篇 |
2019年 | 740篇 |
2018年 | 1051篇 |
2017年 | 999篇 |
2016年 | 957篇 |
2015年 | 863篇 |
2014年 | 1738篇 |
2013年 | 1270篇 |
2012年 | 1279篇 |
2011年 | 1234篇 |
2010年 | 1104篇 |
2009年 | 1126篇 |
2008年 | 851篇 |
2007年 | 908篇 |
2006年 | 829篇 |
2005年 | 737篇 |
2004年 | 651篇 |
2003年 | 556篇 |
2002年 | 476篇 |
2001年 | 447篇 |
2000年 | 304篇 |
1999年 | 272篇 |
1998年 | 156篇 |
1997年 | 163篇 |
1996年 | 154篇 |
1995年 | 148篇 |
1994年 | 116篇 |
1993年 | 76篇 |
1992年 | 113篇 |
1991年 | 75篇 |
1990年 | 77篇 |
1989年 | 68篇 |
1988年 | 64篇 |
1987年 | 36篇 |
1986年 | 41篇 |
1985年 | 36篇 |
1984年 | 36篇 |
1983年 | 39篇 |
1982年 | 49篇 |
1981年 | 45篇 |
1980年 | 42篇 |
1979年 | 41篇 |
1978年 | 29篇 |
1977年 | 35篇 |
1976年 | 26篇 |
1975年 | 23篇 |
排序方式: 共有10000条查询结果,搜索用时 703 毫秒
11.
《Clinical therapeutics》2022,44(7):1012-1025
Statins, or 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, are the mainstay of treatment for hypercholesterolemia as they effectively reduce LDL-C levels and risk of atherosclerotic cardiovascular disease. Apart from hyperglycemia, dyslipidemia and HDL dysfunction are known risk factors for neuropathy in people with obesity and diabetes. Although there are case reports of statin-induced neuropathy, ad hoc analyses of clinical trials and observational studies have shown that statins may improve peripheral neuropathy. However, large randomized controlled trials and meta-analyses of cardiovascular outcome trials with statins and other lipid-lowering drugs have not reported on neuropathy outcomes. Because neuropathy was not a prespecified outcome in major cardiovascular trials, one cannot conclude whether statins or other lipid-lowering therapies increase or decrease the risk of neuropathy. The aim of this review was to assess if statins have beneficial or detrimental effects on neuropathy and whether there is a need for large well-powered interventional studies using objective neuropathy end points. 相似文献
12.
13.
14.
15.
16.
《Journal of clinical densitometry》2020,23(3):459-464
Background: Individuals with cerebral palsy (CP) are at increased risk for obesity and obesity-related complications. Studies of total body fat in those with CP are inconsistent and studies of abdominal fat are lacking in children with CP. The objective of this study was to determine if ambulatory children with spastic CP have greater central adiposity compared to typically developing children. Methodology: Eighteen ambulatory children with spastic CP (n = 5 girls; 8.6 ± 2.9 yr) and 18 age-, sex-, and race-matched typically developing children (controls; 8.9 ± 2.1 yr) participated in this cross-sectional study. Children with CP were classified as I or II using the Gross Motor Function Classification System. Dual-energy X-ray absorptiometry assessed body composition, including total body, trunk and abdominal fat mass, fat-free mass, fat mass index (FMI), and fat-free mass index (FFMI). Results: There were no group differences in fat mass, fat-free mass, FMI, and FFMI in the total body, fat mass, fat-free mass, and FFMI in the trunk, or fat mass, visceral fat mass, and subcutaneous fat mass in the abdomen (p > 0.05). Compared to controls, children with CP had higher trunk FMI, abdominal FMI, and visceral FMI (p < 0.05). Although marginally insignificant (p = 0.088), children with CP had higher subcutaneous FMI. Conclusions: Ambulatory children with spastic CP have elevated central adiposity, especially in the visceral region, despite no differences in measures of total body fat. How this relates to cardiometabolic disease progression in those with CP requires further investigation. 相似文献
17.
18.
BackgroundEvidence suggests that GABA may reduce pancreatic inflammation, protect β-cells from autoimmune destruction, and potentiate the regeneration of new β-cells in the setting of type 1 diabetes mellitus (T1DM). The enzyme GAD, also expressed in human pancreatic β-cells, is an antigenic target of reactive T cells. We hypothesized that treatment of children with recent onset T1DM with GABA or combination GABA with GAD will preserve β-cell function and ameliorate autoimmune dysregulation.MethodsThis is a one-year, prospective, randomized, double-blind, placebo-controlled trial. Ninety-nine patients aged 4–18 years with newly diagnosed T1DM are randomized into three treatment groups: 1) oral GABA twice daily in addition to two injections of recombinant GAD enzyme, 2) oral GABA plus placebo GAD injections, or 3) placebo GABA and placebo GAD. Patients are evaluated at baseline and months 1, 5, 8 and 12. Mixed meal tolerance testing is performed at all but the 8-month visit. Laboratory studies will assess indices of beta and alpha cell function, glycemic control, immunophenotyping, and diabetes-related autoantibodies.ResultsThe primary outcome is the effect on pancreatic β-cell function as measured by meal-stimulated c-peptide secretion compared between the treatment groups before and after one year of treatment. Secondary outcomes include: 1) fasting and meal stimulated glucagon and proinsulin levels, 2) response in insulin usage by participants, 3) indices of immune cell function, and 4) effect on autoantibodies GAD65, ICA512, and ZnT8.Conclusions: This trial will determine the safety and efficacy of GABA and combination GABA/GAD therapy to delay T1DM progression in children. 相似文献
19.
20.