垂宁方治疗泌乳素型垂体瘤的临床疗效观察

【摘要】 目的 探讨垂宁方治疗泌乳素(PRL)型垂体腺瘤的临床疗效,为临床应用提供借鉴依据。方法 将2014年1月至2015年1月收治的60例PRL型垂体瘤随机分为A组、B组和C组。A组患者采用垂宁方进行治疗,B组患者采用溴隐亭进行治疗,C组患者采用溴隐亭联合垂宁方进行治疗;治疗6个月及1年时对患者的瘤体积、血清PRL水平及中医症候积分量表得分进行对比评价。结果 治疗6个月及1年时C组患者肿瘤大小改善情况明显优于A组和B组,差异有统计学意义（P<0.05）;治疗后3组患者血清PRL水平均显著降低（P<0.05）,C组血清中PRL水平改善程度显著高于其余两组（P<0.05）,且开始治疗后C组患者PRL水平均明显低于A组和B组,差异具有统计学意义（P<0.05）;经治疗后C组患者中医证候评价结果明显优于其余两组,差异具有统计学意义（P<0.05）。结论 垂宁方治疗PRL型垂体瘤具有理想的治疗效果,可有效抑制瘤体生长,降低患者血清中泌乳素水平,改善患者预后。     

用于远程心电监护系统的心电信号自动分析和诊断方法

提出了一种基于远程心电监护系统的心律分析和诊断方法。该方法首先以多数据缓冲方式整合分包传输的心电数据;然后以心电数据的二阶差分值为主要依据,自动检测R波波峰;最后依据检测结果,对受试者心律进行初步诊断。测试结果表明,本方法能够满足远程心电监护系统的准确、实时和稳定等要求。     

Treatment strategy for early gastric cancer

Gastric cancer ranks the second leading cause of cancer-specific mortality worldwide. With a poor prognosis, 5-year survival rate of gastric cancer is less than 20%-25% in the USA, Europe, and China [1]. However, early gastric cancer(EGC) offers an excellent (over 90%) chance of cure based on surgical resection [2]. As the increasing detection of EGC, more treatment options have been developed both curatively and minimally invasively to maintain a good quality of life(QOL). One of the advanced therapeutic techniques is endoscopic dissection. Improvements in surgical treatment include minimizing lymph node dissection, reconstruction methods, laparoscopy-assisted surgery, and sentinel node navigation surgery(SNNS) [3]. With technological advances, even Natural Orifice Transluminal Endoscopy Surgery (NOTES) and robotic surgery are expected to represent the next revolution [4]. However, there still remains much dispute among these treatments, which arouses further clinical trials to verify. Update of the treatments, controversial indications, prognosis and current strategies for EGC are discussed in this review.     

医院核心竞争力的培养原则和条件

医院获得长期竞争优势是由医院拥有的核心竞争力决定的。文章通过对医院核心竞争力概念及内涵的研究,提出了核心竞争力的培养原则和培养条件。     

医院文化与医院核心竞争力

医院独有的文化和综合实力为依托的核心竞争力,是医院兴旺发达的生命之源。本文介绍了医院文化的产生背景,与医院核心竞争力的关系,并对如何用医院文化建设提升医院核心竞争力的问题进行探讨。     

分步离心和梯度离心制备大鼠脑突触体方法的比较

通过比较了单层蔗糖分步离心和不连续蔗糖梯度离心制备的大鼠脑突触体对5-羟色胺和去甲肾上腺素的再摄取能力。结果表明,采用分步离心法可减少制备突触体的时间,降低操作难度,所得脑突触体具有有效蛋白含量较高、稳定性较好的优势。该法所制备的突触体对相应递质的特异性摄取能力有所提高。     

酒石酸拉索昔芬的合成

6-甲氧基-1-四氢萘酮与1-[2-(4-溴苯氧基)乙基]吡咯烷缩合后,经三溴化吡啶鎓溴代,与苯硼酸进行Suzuki偶合、钯炭催化加氢、48%氢溴酸脱甲基后,经D-酒石酸拆分成盐得酒石酸拉索昔芬,总收率约15%[以1-[2-(4-溴苯氧基)乙基]吡咯烷计]。     

AKT/ERK activation is associated with gastric cancer cell resistance to paclitaxel

Paclitaxel (PTX) has shown encouraging activity in the treatment of advanced gastric cancer (GC). However, the fact that more than half of GC patients respond poorly to PTX-based chemotherapies demonstrates the urgent need for biomarkers of PTX sensitivity in GC patients. In the present work, three GC cell lines (BGC-823, HGC-27 and NCI-N87) with different sensitivities to PTX were subjected to DNA microarray analysis. The significantly differentially expressed genes and microRNAs (miRs) were identified and pathway signatures for PTX sensitivity were proposed. Ingenuity Pathway Analysis results showed that the differentially expressed genes were mainly enriched in the ErbB signaling pathway and other pathways. Additionally, the AKT/ERK signaling pathway, which is the pathway downstream of ErbB, was predicted to be active in PTX-resistant GC cell lines. ErbB3 overexpression and AKT/ERK activation in PTX-resistant cell lines were validated, respectively, by quantitative PCR and immunoblotting. Furthermore, 10 miRs were dramatically differently expressed in the three GC cell lines, and a miR-gene network was constructed from these data. Our work uncovered a reliable signature for PTX sensitivity in GC and potential therapeutic targets for GC treatments.     

PGAA,PGAI and NT with cold neutrons: Test measurement on a meteorite sample

First comprehensive analysis with PGAA, Prompt Gamma-ray Activation Imaging (PGAI) and neutron tomography (NT) techniques at the research reactor FRM II was tested on a piece of the Allende meteorite.With the PGAA method the bulk elemental composition of the heterogeneous meteorite was determined. Due to the small dimension of the sample, only the 2D elemental distribution of the object was derived with position sensitive PGAI analysis. As an example 2D maps for Si, Fe and Mg are presented. Neutron tomography of the meteorite was carried out with the same cold neutron beam.     

Ultrasound-Guided Supraclavicular Brachial Plexus Block for Analgesia during Endovascular Treatment of Dysfunctional Hemodialysis Fistulas

PurposeTo evaluate prospectively the efficacy and safety of ultrasound (US)-guided supraclavicular brachial plexus block (BPB) for analgesia during endovascular treatment of dysfunctional hemodialysis fistulas.Materials and MethodsUS-guided supraclavicular BPB was performed before endovascular treatment of dysfunctional hemodialysis fistulas in 40 consecutive patients. After BPB, standard interventional procedures were performed for treatment of dysfunctional hemodialysis fistulas. A visual analog scale (0–10) was used to assess pain related to performance of BPB immediately after the endovascular procedure. Patient satisfaction and operator satisfaction during the procedure were also assessed after the procedure.ResultsSatisfactory regional anesthesia and analgesia were achieved in all patients without a need for supplemental intravenous analgesia. The mean onset time for complete block was 5.4 minutes ± 2.6. Pain scores were 0 (no pain) in 26 patients and 1–3 (mild, annoying pain) in 14 patients. The patient’s satisfaction with pain control was recorded as satisfied (very well) in all cases. The operator’s satisfaction with this anesthetic technique was also recorded as satisfied (very well) in all cases. Complications related to the block procedure did not occur in any patient.ConclusionsUS-guided supraclavicular BPB can be used safely to provide analgesia during endovascular treatment of dysfunctional hemodialysis fistulas in adult patients.