86例异位妊娠的超声诊断价值

目的：探讨B超对异位妊娠的诊断价值。方法：对2004年1月～2009年1月的86例异位妊娠患者，采用超声诊断仪进行检查、分析。结果：超声检查的86例异位妊娠患者，诊断符合84例，确诊率为97．6％，误诊2例，误诊率为2．4％。结论：超声检查有着无创性、可重复性等不可比拟的优越性，为异位妊娠患者的诊断及治疗提供了可靠的依据。     

基于骨和无有机成分骨与羟基磷灰石压缩性能实验比较的强度分析

目的分析判定以珊瑚为基体,通过水热交换法制成的羟基磷灰石植入体内后的强度是否可以达到活体骨的水平。方法实验测量羟基磷灰石、含有机成分的骨、无有机成分的骨的压缩极限应力。通过对比羟基磷灰石、骨及无有机成分的骨的压缩强度差别,确定胶原纤维对骨压缩强度的作用,进而应用经验模型预估人造羟基磷灰石在一定空隙度(0.1～0.5)范围变化时的强度。结果羟基磷灰石、骨及无有机成分的压缩强度分别为14.1 GPa、207 GPa和31.7 GPa。结论去除骨中的有机成分后其压缩强度降低约80%。水热交换法制成的羟基磷灰石抗压强度可能高于骨内羟基磷灰石,这种骨替代材料植入体内后,随着骨和纤维组织在内部生长,其强度有可能达到活体骨的水平。     

Reconstruction of Soft Tissue Defects in the Hand with a Free Anterolateral Thigh Deep Fascia Flap

ObjectiveTo report our experience in the reconstruction of soft tissue defects in the hand with a free anterolateral thigh deep fascia flap and describe the clinical outcomes.MethodsThis study was a retrospective trial. From November 2016 to January 2020, six patients (four men and two women) with soft tissue defects in the hand were included in this study. The average age of the patients was 33.7 ± 12.7 years (range, 20 to 50 years). All patients underwent reconstructions with free anterolateral thigh deep fascia flaps. Relevant clinical characteristics were recorded prior to surgery. The size and thickness of the deep fascia flap and the thickness of the skin were measured intraoperatively. The survival of the flaps and skin grafts and the occurrence of infection were recorded after the operation. At follow‐up, donor site complications and postoperative effects were evaluated according to the outcome satisfaction scale. The pain in the injured hand was assessed using the visual analog scale.ResultsThe average body mass index (BMI) was 26.6 ± 1.7 kg/m² (range, 23.9 to 28.7 kg/m²). The defect sizes ranged from 5 cm × 5 cm to 13 cm × 8 cm (average, 53.1 ± 27.9 cm²). The six anterolateral thigh deep fascia flaps ranged from 7 cm × 6 cm to 14 cm × 9 cm in size (average, 71.8 ± 29.1 cm²). The thicknesses of skin ranged from 25 mm to 40 mm (average, 32.5 ± 4.8 mm), and the thicknesses of the deep fascia flaps ranged from 2 mm to 3 mm (average, 2.5 ± 0.5 mm). After the operation, the blood supply of the deep fascia flap was normal in all cases. The second‐stage skin grafts of most patients survived completely. The skin graft in one case was partially necrotic and healed after a dressing change. No infection occurred. At follow‐up (average, 16.3 ± 6.9 months), there was only a linear scar and no loss of sensation at the donor site of each patient. According to the outcome satisfaction scale, the outcome satisfaction score ranged from 6 to 8 (average, 7.2 ± 0.9), all of which were satisfactory. Apart from one patient who reported mild pain, all the other patients reported no pain. Three typical cases are presented in this article.ConclusionsThe free anterolateral thigh deep fascia flap, which is suitable for reconstruction of soft tissue defects in the hand, can provide very good outcomes both functionally and aesthetically.     

抗柯萨奇B中药胶囊治疗病毒性心肌炎的临床疗效评价

目的观察抗柯萨奇B心肌炎胶囊(ACCM)治疗病毒性心肌炎(VM)的临床疗效.方法将120例VM患者随机分成ACCM组(用ACCM治疗,60例)和对照组(西药常规治疗,60例),进行对比观察.结果ACCM组总有效率85%,明显优于对照组的57%(P<0.05).治疗后ACCM组的心悸、反复感冒、胸闷、胸痛、气短、乏力、头晕等症状的恢复明显优于对照组.结论ACCM是治疗VM的一种高效、价廉及使用方便的中药制剂, 无明显不良反应.     

小梁切除术联合自体巩膜植入术治疗青光眼的临床研究

目的观察小梁切除术联合自体巩膜植入术治疗青光眼的临床疗效。方法对12例(12眼)青光眼患者施行小梁切除术联合自体巩膜植入术。术后观察眼压、视力、滤过泡形态、并发症等,并做超声生物显微镜(UBM)观察。结果经3～18mo的随访,术后视力11眼(92%)维持不变或提高。眼压由术前平均(36.15±11.39)mmHg降至术后1a平均(13.21±4.98)mmHg,有非常显著性差异(P<0.01),末次随访眼压≤21mmHg者11眼(92%),其中9眼形成弥散性滤过泡,术后前房轻度变浅4眼,术后3～7dUBM检查睫状体脱离2眼,无其它并发症发生。结论小梁切除术联合自体巩膜植入术,能有效降低眼压,经济安全术后视力稳定,值得临床应用推广。     

乳腺包裹性乳头状癌三例并文献复习

目的:提高对乳腺包裹性乳头状癌（EPC）的认识。方法:回顾性分析2015、2020年河北省人民医院收治且确诊为EPC 3例患者的临床资料,并复习相关文献。结果:3例患者均为绝经后老年女性。2例患者超声表现为囊实性团块。病理检查均表现为界限清楚、有厚的纤维包膜所包围的囊性病灶,囊内以纤细的乳头状结构为主,中央为缺乏肌上皮...     

荞麦花叶提取物对S180荷瘤小鼠的辅助治疗作用

目的:研究荞麦花叶提取物(extraction of buckwheat flower and leaf,EBFL)对肿瘤的辅助治疗作用,并探讨其可能的机制。方法:建立小鼠S180肿瘤模型;分别ig荞麦花叶提取物200,400 mg.kg-1及与环磷酰胺(CTX)联合给药14 d,实验重复3次。测定荷瘤小鼠的生存期、肿瘤抑制率、白细胞计数、胸腺指数、脾指数,同时测定荷瘤小鼠血清中白细胞介素-2(IL-2),肿瘤坏死因子-α(TNF-α)水平。结果:与模型组相比,EBFL对肿瘤抑制作用不明显,但可使荷瘤小鼠生存期明显延长,25 d生存率以CTX+EBFL-H组最高(35%),其次是EBFL-H(25%)和EBFL-L(20%);与CTX阳性对照组比较,EBFL能明显抑制CTX所致白细胞数量减少及免疫器官指数降低(P<0.05,P<0.01);EBFL可提高IL-2水平,但对TNF-α水平无影响。结论:EBFL可改善荷瘤小鼠生存质量,延长生存期,减轻CTX的毒性,其机制可能是通过提高机体免疫力实现的。     

解聚复肾宁治疗早期2型糖尿病肾病

目的: 探讨解聚复肾宁治疗早期糖尿病肾病（DN）的临床疗效。 方法: 研究对象为我院收治的120例早期2型DN患者,将其随机分为解聚复肾宁组、厄贝沙坦组、解聚复肾宁+厄贝沙坦组、对照组。每组各30例,12周为1疗程,观察各组治疗前后相关指标的变化。 结果: 解聚复肾宁组治疗后空腹血糖、24 h尿微量白蛋白排泄率、血肌酐、糖化血红蛋白等指标显著好转,血清和尿液中血管紧张素Ⅱ（AngⅡ）,结缔组织生长因子（CTGF）均显著降低,解聚复肾宁和厄贝沙坦联合治疗明显优于两类药物单独应用（P<0.05）。 结论: 解聚复肾宁对早期2型DN疗效确切,可延缓病情进展,提高患者的生活质量,值得临床推广使用。     

解偶联蛋白在脑缺血疾病中的作用研究进展

解偶联蛋白(uncoupling proteins,UCPs)是一类位于线粒体内膜上的阴离子载体蛋白,属于线粒体载体蛋白超家族。到目前为止,已经发现并确认UCPs同系物为5种,即UCP1～UCP5,中枢神经系统中主要含有UCP2,UCP4和UCP5 3种亚型,已经证实其对于脑缺血后的氧化应激、线粒体膜电势及ATP绝对水平的维持具有重要的作用,本文主要将UCPs在脑缺血疾病中相关作用进行综述,希望可以为脑缺血疾病的治疗提供新的研究思路。