应用新型球囊Hyperglide或Hyperform辅助弹簧圈技术栓塞治疗颅内宽颈动脉瘤(附22例分析)

目的探讨采用新型MTI球囊重塑技术栓塞治疗颅内宽颈动脉瘤的可行性及有效性。方法总结22例26个宽颈动脉瘤的栓塞治疗经验。均采用新型球囊Hyperglide或Hyperform置于载瘤动脉处,同时将微导管置于动脉瘤内,充盈球囊以封闭瘤颈口后将合适的弹簧圈推送进入动脉瘤内,重复进行充盈球囊和填塞过程,直至动脉瘤致密填塞。结果19例23个动脉瘤成功填塞;1例前交通动脉瘤因血管迂曲致球囊不能到位而改用其他技术栓塞;另1例前交通动脉瘤因球囊选择不当,瘤颈封堵不完全,导致部分弹簧圈移位进入载瘤动脉;1例动脉瘤术中破裂出血,病人死亡。结论新型球囊重塑技术有助于达到宽颈动脉瘤致密、有效的栓塞。     

Study of electroacupuncture with different frequencies for the treatment of headache and anxiety-depression symptoms in patients with migraine: A randomized clinical trial: 不同频率电针改善偏头痛患者头痛及焦虑抑郁症状的差异性研究-随机临床试验

ObjectiveTo observe the effects of electroacupuncture (EA) with varied frequencies on headache and anxiety-depression symptoms in patients with migraine and to screen optimal frequency of EA for patients with such conditions.DesignSingle-center, randomized, controlled clinical trial was designed, and the outcome assessors and statisticians were blinded. The patients with migraine were randomized into 2 Hz EA group, 100 Hz EA group and sham-stimulation group. In each group, the changes in migraine attacks, days with headache, the scores of visual analogy scale (VAS), self-rating anxiety scale (SAS), self-rating depression scale (SDS) and migraine-specific quality-of-life questionnaire (MSQ), as well as the dosage of analgesics were observed at the baseline, during treatment, in 1, 2 and 3 months of follow-up separately.SettingPatients were enrolled in the Third Affiliated Hospital of Zhejiang Chinese Medical University, between 1^st August 2018 and 31^st July 2021.ParticipantsSixty-five migraine patients with or without aura.InterventionsIn the EA groups, the acupoints were bilateral Fengchi (GB20), Gongxue (Extra), Sizhukong (TE23), Taiyang (EX-HN5), Shuaigu (GB8), Waiguan (TE5) and Yanglingquan (GB34). Electric stimulation was exerted at GB20 and Gongxue (Extra), with 2 Hz and 100 Hz separately. In the sham-stimulation group, the shallow acupuncture was operated at the sites 1 cm lateral to GB20 and Gongxue (Extra), and on the radial side of TE5 and GB34. The output wires were cut off after attached to the acupoints. The patients in each group received the treatment 3 times weekly, once every two days, for consecutive 4 weeks. The complete intervention was composed of 12 treatments.Main outcome measuresChanges in numbers of migraine attacks at treatment phase (week 1 to week 4) from the baseline(week -4 to week 0) in patients of each groupResults(1) Changes in migraine attacks and days with headache: In the 2 Hz EA and 100 Hz EA groups, the changes for migraine attacks and days of headache were higher significantly when compared with that in the sham-stimulation group at the same time stage (P < 0.05). There was no statistical difference between two EA groups. (2) Changes of VAS score: In the 2 Hz EA and 100 Hz EA groups, the changes of VAS score were significantly higher when compared with that in the sham-stimulation group at the same time stage (P < 0.05). There was no statistical difference between two EA groups. (3) Assessment of anxiety and depression: The differences in the changes of SAS and SDS scores had no statistical significance in patients of each group at each assessment stage (P > 0.05). (4) Assessment on the quality of life: Compared with the sham-stimulation group at the same time stage, the improvement in MSQ score was increased significantly during treatment in patients of the 2 Hz EA and 100 Hz groups (P < 0.05). There was no statistical difference between two EA groups. (5) Assessment on safety and compliance: The patients of each group had sound compliance. There was no adverse events during trial, suggesting promising safety of treatment.ConclusionEA may effectively reduce the migraine attacks, and the days and intensity of headache, presenting promising safety. However, there was no significant improvement on anxiety-depression symptoms, and no significant difference between high and low frequencies of EA treatment in relieving headache and anxiety/depression symptoms in the patients with migraine.Trial registrationChiCTR1800017259     

辨证治疗中风病248例临床分析

本文通过对２４８例中风病临床分型分析，以气虚血瘀证最多，占３８．３１％，其次为阴虚风动证，肝阳暴亢，风火上扰证。本组病人不论是出血性中风，还是缺血性中风，均采用中药辨证治疗基础上，口服中成药及静脉滴注活血化瘀针剂以加强活血化瘀、涤痰通络这一治疗法则，总有效率为８４．２７％，其中出血性中风和缺血性中风的总有效率分别为８６．９５％和８３．２４％，对血液流变学、脑出血患者治疗前后脑ＣＴ对照观察，认为 一     

急性上消化道出血112例临床疗效分析

采用国家中医药管理局颁布的《中医血证治疗常规》治疗急性上消化道出血112例，取得了较好疗效，总有效率达94．6％。进行了证和疗效，原发病和疗效，病情程度和疗关系的分析。说明中医血证治疗效常规在临床实践中是切实可行的。     

湖北麻城2000～2002年农村妇女自杀死亡流行病学分析

目的 分析农村妇女自杀死亡的流行病学特点及其自杀原因，为制定预防对策提供科学依据。方法 采用描述性流行病学方法分析湖北麻城2000年～2002年15a以上妇女自杀死亡病例249例，并与八年前该地区农村妇女自杀情况进行比较。结果 该地区农村妇女自杀年龄分布呈“马鞍”现象，人际冲突、患病自感难愈、经济困难为自杀的前三位原因。与丈夫冲突导致自杀的比例比八年前该地研究结果显著增高，且是20～39a组自杀死亡的首位原因；15～29a组自杀比例显著下降，而50～69a组自杀比例显著上升。结论 农村妇女自杀死亡是由多种因素造成的，应引起高度重视并制定有效的综合干预措施。     

基于Internet的生物信息资源快速查找与利用

生物信息学是现代生命科学与信息科学、计算机科学、数学、统计学、物理学、化学等学科相互渗透而高度交叉形成的一门新兴前沿学科.生命科学的所有信息均可由计算机和因特网来进行储存、分析和传输.因特网为我们提供了大量的有关生物信息相关的数据、工具、文献、软件等资源.本文根据笔者的实践经验,对因特网上生物信息资源进行了整理和分类,总结了因特网上获取生物信息资源的途径及其利用,介绍了一些快速查找方法与技巧,以便读者更迅速更准确利用因特网上生物信息资源.     

乳腺癌分期辨证规范化——一个中医乳房病学与时俱进的重要课题

乳腺癌的发病率近年来呈上升趋势,在经济发达地区已经成为女性发病率最高的恶性肿瘤。长期的临床实践表明中医药在乳腺癌治疗中有着不可或缺的作用。但其理论模式比较滞后,制约着中医药治疗乳腺癌的临床、教学与科研的发展。本文从临床疾病谱的变化、现代医学治疗乳腺癌存在的不足以及目前临床实际存在的问题,阐述了中医药治疗乳腺癌分期辨证规范化的制订和实施的重要性与迫切性,同时也分析了乳腺癌分期辨证规范化研究的基础、思路和方法。     

参麦注射液中人参皂苷Rg1和Re药代动力学研究

目的研究参麦注射液中人参皂苷Rg₁和Re人体药代动力学。方法采用已建立的LC/MS/MS法同时测定人血浆中人参皂苷Rg₁和Re浓度，并计算其药代动力学参数。结果人参皂苷Rg₁和Re线性范围为1.023-1 023 μg·L^-1和1.05-1 050 μg·L^-1，方法回收率在99%-105%和99%-104%，日内、日间RSD值均小于15%。参麦注射液60 mL经静脉滴注后人参皂苷Rg₁和Re的药时曲线均符合二房室开放模型，T_1/2α分别为0.28 h和0.10 h，T_1/2β分别为2.1 h和1.2 h。结论该法简便、灵敏、特异，适用于血浆中人参皂苷Rg₁和Re浓度的测定。参麦注射液中人参皂苷Rg₁和Re在人体内血药浓度较低，分布和消除速度较快，药代动力学行为符合二房室模型。     

芒果苷对胰岛素抵抗HepG2细胞糖脂代谢的影响

目的:分析芒果苷(MGF)对胰岛素抵抗HepG2细胞(IR-HepG2细胞)糖脂代谢的影响,并探讨潜在机制.方法:以人肝癌HepG2细胞为对象,以1 mmol/L棕榈酸+2 mmol/L油酸联合培养建立IR-HepG2细胞模型.以盐酸二甲双胍为阳性对照,分别检测低、中、高浓度MGF(125、250、500μmol/L)...     

全膝关节置换术后疤痕区皮肤偶发分枝杆菌感染一例

患者,女,68岁。左膝全膝关节置换术后5年,左膝胫骨结节手术疤痕表皮破溃3天。伤口拭子细菌培养示偶发分枝杆菌。从发病时间、影像提示假体周围软组织感染性病变、多次手术探查均考虑筋膜层完整,我们认为本患者属于术后外界环境种植。给予抗结核药物治疗及植皮手术,患者逐渐好转。