Intrathoracic infections in Hodgkin lymphoma (HL) patients may cooperate with HL to trigger hemophagocytic lymphohistiocytosis: A retrospective study

Hodgkin lymphoma (HL)-related hemophagocytic lymphohistiocytosis (HLH) has been reported in the literature; however, there is almost no literature on the factors related to HL triggering HLH.One hundred forty patients with HL were retrospectively analyzed. The incidence of HL-related HLH (we call HL-related HLH as HL-HLH). And all HL-HLH patients in our cohort had HLH as the first manifestation and its clinical characteristics and the role of intrathoracic infection (ITI) in triggering HLH are discussed.The 140 patients with HL mainly included mixed-cellularity classic HL (MCCHL) in 81 (57.9%), nodular sclerosis classic HL (NSCHL) in 36 (25.7%), and lymphacyte-rich classic HL in 14 (10.0%) patients. Of the 137 patients who underwent chest computed tomography scans on admission, 44 had ITI, and most of these ITI were mildly ill and had no respiratory symptoms. Among 140 HL patients, 8 patients from MCCHL were diagnosed as HL-HLH. Among 81 MCCHL patients, 26 patients with ITI had a significantly higher incidence of HL-HLH than those without ITI (26.9% vs 1.8%, P = .002). The median survival time of 8 cases of HL-HLH was only 2 months.When HL patients were first admitted to the hospital, 5.7% had HLH as the first manifestation, and 32.1% had ITI. These ITI can cooperate with HL to trigger HLH, despite their mild illness. The prognosis of HL-HLH was poor.     

108例MB麻风初治MDT 24个月BI阴转分析

目的探讨MB麻风病人初治MDT 24个月细菌B I阴转变化情况。方法采用WHO推荐的MDT MB两年方案对新登记的108例MB患者进行疗前、疗中、疗后查菌对比。结果涂片查菌B I 24个月平均下降68.2%,完全阴转26例(24.07%),有82例(75.93%)在疗程结束时仍查菌阳性。结论采用MDT治疗麻风患者,能够在较短限期内改善临床症状,但要试图通过药物改变机体的排菌率以达到细菌快速阴转是不现实的。提示MB病人初治MDT MB两年方案后,仍需加强疗后监测至少5年,有条件时应采用MDTMB至临愈或施行监测加DDS单疗巩固,不应盲目判愈或停止监测。     

Status and influencing factors of patients with kinesiophobia after insertion of peripherally inserted central catheter: A cross-sectional study

This study aimed to investigate the current status and influencing factors of kinesiophobia in patients after insertion of peripherally inserted central catheter (PICC).A total of 240 patients with PICC were included. Their postinsertion status and influencing factors were investigated using the general information questionnaire, Tampa Scale of Kinesiophobia (TSK), Medical Coping Modes Questionnaire, Numerical Rating Scale, and Self-rating Anxiety Scale.The mean TSK score was 36.49 ± 4.19 points, and 89 patients (37.08%) had kinesiophobia. Multiple linear regression analysis showed that factors such as education level, age, monthly income level, catheterization history, face, pain level, anxiety, and number of needle insertions influenced postoperative kinesiophobia in patients with PICC (P < .05). The total variation in the TSK score was 71.8%.The incidence of kinesiophobia was relatively high after PICC insertion. The medical staff needs to undertake targeted intervention measures to help minimize kinesiophobia after PICC insertion, allowing patients to perform scientifically correct functional exercises and attain physical recovery.     

bFGF对慢性酒精中毒大鼠肝组织ATP酶活力的影响

目的观察碱性成纤维细胞生长因子（bFGF）对慢性酒精中毒大鼠肝组织Na^＋-K^＋-ATP酶活力和Ca^2＋-Mg^2＋-ATP酶活力的影响,探讨bFGF对慢性酒精中毒所致的肝损伤的保护作用。方法选择成年Wistar雄性大鼠,采用白酒灌胃建立慢性酒精中毒模型,慢性酒精中毒模型建立成功的大鼠随机抽签法分为酒精中毒对照组、生理盐水（NS）对照组和bFGF治疗组。另10只不灌白酒作为正常对照组。bFGF治疗组大鼠白酒灌胃的同时,1h后按12μg/kg剂量肌肉注射,共14d。各组大鼠到相对应的时间点取出肝组织制成匀浆,测定肝组织匀浆中Na^＋-K^＋-ATP酶活力和Ca^2＋-Mg^2＋-ATP酶活力。结果与正常对照组相比,慢性酒精中毒后大鼠肝组织中Na^＋-K^＋-ATP酶活力及Ca^2＋-Mg^2＋-ATP酶活力均明显降低（P〈0.05）;经bFGF治疗后肝组织中Na^＋-K^＋-ATP酶活力和Ca^2＋-Mg^2＋-ATP酶活力均明显高于酒精中毒对照组及NS对照组（P〈0.05）。结论 bFGF能提高慢性酒精中毒肝组织中Na^＋-K^＋-ATP酶活力及Ca^2＋-Mg^2＋-ATP酶活力,提示bFGF对慢性酒精中毒所致的肝损伤具有保护作用。     

公立医院管理体制改革的模式和特点

管理体制是公立医院改革的关键点.公立医院管理体制改革的本质是管理权和监督权的结构调整.文章首先将公立医院管理体制分为融合型和分立型两种模式,阐述两种管理体制的主要特点和基本逻辑.提出了推进融合型公立医院管理体制改革的政策建议,即以供需矛盾为客观形势、以管制失灵为假设、以下放管理权为关键、以上收监督权为保障、以活力和秩序均衡为目的、以利义兼得为结果的制度重构过程.     

Nutrition education and changes in nutrition behavior among the 65-74-year-old population of Eastern Finland

This study examined the sources of nutrition information in eastern Finland in 1982. We considered the quality of the information available, and the usability of this information, and reported changes in nutrition behavior among the population 65–74 years of age. The respondents identified TV and radio as the main sources of nutrition information. Compared to men, women had more often read about nutrition issues in newspapers, magazines, and books. The elderly population had been able to understand the information, but only half of them had been able to follow the instructions. The proportion of the elderly population that reported having made some changes in their nutrition habits ranged from 8% to 35% of males and from 16% to 57% of females, depending upon the habit queried. Lower fat consumption was associated not only with decreased fat intake over the previous year, but also with other reported positive changes among both sexes. Not smoking was also related to positive changes in nutrition in both sexes. The various positive health habits appear to reinforce each other, at least among the population we studied.     

海尔福口服液对O2^-清除率的实验研究

目的:探讨海尔福口服液对超氧阴离子自由基(O2-)的清除效果及其机理。方法:用AP-TEMED系统比色法测定海尔福口服液对O2-的清除率,并与维生素C及金银花提取液作对比分析。结果:海尔福口服液(内含金银花生药0.1g/ml)、金银花水提取液(含生药0.1g/ml)、维生素C(浓度1.0mg/ml)对O2-的清除率分别是(92.71±2.79)、(81.15±3.81)、(92.67±5.46),加样量分别为1.0、0.5、0.25、0.125ml时,它们的相关系数分别为0.9697、0.9959、0.9988,有直线相关关系;三种存放时间不同的金银花提取液对O2-的清除率分别是(81.15±3.81)、(87.70±1.41)、(37.94±11.79),差异显著(P<0.05和<0.01);海尔福口服液生产过程中的不同阶段对O2-的清除率无显著性差异(P>0.05);海尔福口服液的其余主要原料如茯苓、甘草等对O2-的清除率均较低。结论:海尔福口服液及其主要原料之一金银花提取液在体外对O2-均有明显的清除作用,其效果与浓度为1.0mg/ml的维生素C溶液接近;金银花原料短期存放功效无明显变化,长期存放对O2-的清除率明显降低;海尔福口服液在生产过程中的不同阶段对O2-的清除率无明显变化。     

腹直肌外侧入路与髂腹股沟入路切开复位内固定治疗幼儿Torode-Zieg Ⅳ型骨盆骨折的疗效比较

目的:比较腹直肌外侧入路与髂腹股沟入路切开复位内固定治疗幼儿Torode-Zieg Ⅳ型骨盆骨折的临床疗效。方法:采用回顾性队列研究分析2012年6月至2019年6月右江民族医学院附属医院和南方医科大学第三附属医院收治的12例幼儿Torode-Zieg Ⅳ型骨盆骨折患者临床资料,其中男6例,女6例;年龄13~36个月［...     

B超引导下微创经皮肾镜取石术治疗肾结石363例报告

目的:探讨运用超声引导下微创经皮肾镜取石术治疗肾结石的疗效及适应证。方法:回顾性分析2006年4月～2009年2月间采用超声引导下微创经皮肾镜取石术治疗肾结石患者363例共367只肾的临床资料。结果:363例367只肾中,B超定位引导下成功穿刺并建立人工取石通道者360例364只肾(99.18%);一期手术取石342例,二期手术22例;一次清石成功率为82.83%(304/367肾),11例(3.00%)需二次取石手术,49例术后1个月需辅以ESWL治疗。全部患者术后解除结石梗阻。手术平均时间约118min,出血量在20～550ml之间,平均130ml,平均住院日11.6d。结论:B超引导下微创经皮肾镜取石术治疗肾结石成功率高,创伤小,安全可靠,值得在临床上推广使用。