视网膜与松果体相关关系研究现状

就近年关于对视网膜与松果体在胚胎期的发生与形成、在成年时期的结构与功能等诸多方面的相似性进行了探讨，同时对两者的相互关系与相互影响进行了分析。随着对该领域不断深入的探讨，将有益于对视觉的重新认识和眼科临床的发展。     

玻璃体切除术治疗严重眼外伤34例观察

目的:观察玻璃体切除术治疗严重眼外伤的临床效果。方法:应用玻璃体切除术治疗严重眼外伤34例(35眼)。结果:本组34例(35眼)中,术后视力提高者29例(30眼,86%),在0.05以上者18例(18眼,51%),4例复发视网膜脱离,3例再手术成功。结论:玻璃体切除术是目前治疗严重眼外伤较为理想的方法,对恢复视功能起到一定作用。     

Effects of dietary fiber and protein on rat erythrocyte insulin-receptor interaction

The metabolic effects of cellulose on insulin receptor interaction (IRI) was studied at 10 and 20 percent protein levels in male weanling Sprague Dawley rats. One hundred and four (104) rats were divided into 8 groups of 13 each and randomly put on various dietary treatments as already reported elsewhere [Fed. Proceed. 1985; 44(5):6367]. Animals for radioreceptor studies (n=5 per group) were fed for 8 weeks. Blood samples were obtained from the rats via cardiac puncture under nembutal anesthesia. Erythrocyte IRI and serum insulin levels (IN) were measured by a standardized radioreceptor assay (10) and radioimmunoassay respectively. Fiber and protein intake had significant effect on IRI (p<0.01) and IN (p<0.05). Specific percent 125_I-insulin binding (SIB) was higher in the 20% protein group at all fiber levels while in the fiber free groups higher SIB was observed in the 10% protein group (p<0.01). At both protein levels, maximum SIB was observed at the 5% fiber level. While SIB in the absence of fiber was observed to be strictly a function of receptor site concentration (Ro) binding in the presence of fiber was a function of both Ro and empty site affinity (Ke). Fiber intake appears to interfere with the negative cooperative nature of the receptor sites by slowing down the rate of changing affinity from a high Ke to the limiting K_f (filled site affinity) state as receptor occupancy [Y=Long [B]/Ro] increases. While no significant effect of calorie was observed on e and _f, caloric intake (Cal) showed a positive correlation (r=0.8, p<0.001) with IN and a negative (r=0.32, p<0.02) correlation with Ro. It is concluded that: (I) diet can modulate erythrocyte IRI in growing animals, (II) the metabolic effects of dietary fiber depend on the combination with other nutrients, (III) adequate protein nutrition is essential for plasma membrane function at the cell receptor level in growing animals and (IV) the increase in IRI by dietary fiber is a function of both e, Ro and the sustenance of the average affinity of these homogeneous class of receptor sites in the high affinity states.     

2001-2013年邯郸市他汀类药物不良反应分析

目的了解邯郸市各医院使用的他汀类药物不良反应（ADR）发生情况,为临床合理用药提供依据。方法对邯郸市药品不良反应监测机构上报的2001--2013年他汀类药物不良反应登记资料进行回顾性统计分析。结果ADR累及多个系统一器官,主要包括肝胆、胃肠、肌肉骨骼及神经系统,其他系统相对少见。严重不良反应以肝损害最常见;不同他汀类ADR有所差异,辛伐他汀主要累及肌肉骨骼、胃肠系统和肝胆系统,阿托伐他汀主要累及肝胆和神经系统,氟伐他汀主要累及胃肠系统。结论目前在临床上应用的他汀类药物在常规剂量范围内均有ADR发生,应规范降脂用药剂量和时限,减少不良反应发生。     

辛伐他汀治疗冠心病患者下肢动脉粥样硬化斑块疗效观察

目的探讨辛伐他汀40mg/d对冠心病患者下肢动脉粥样硬化的影响。方法将96例经冠状动脉造影和下肢动脉超声诊断的冠心病下肢动脉粥样硬化患者随机分为辛伐他汀40mg组及辛伐他汀20mg组,每组48例,于给药前、给药3个月和9个月后采用高频超声检测下肢动脉,记录下肢动脉内膜中层厚度（IMT）。结果辛伐他汀20mg或40mg治疗3个月和9个月后,40mg组较20mg组作用更为明显（P〈0.01）,治疗3个月和9个月后辛伐他汀40mg组的下肢动脉IMT均较治疗前明显下降（P〈0.01）,而辛伐他汀20mg组IMT无显著改变（P〉0.05）。结论辛伐他汀40mg/d对冠心病患者的下肢动脉粥样硬化斑块具有稳定和延缓作用。     

糖心合剂对2型糖尿病合并心功能不全患者心功能的影响

目的探讨糖心合剂对2型糖尿病合并心功能不全患者心功能的影响。方法将49例2型糖尿病合并心功能不全患者随机分为对照组20例、治疗组29例,对照组采用西药常规治疗(强心剂、利尿剂、血管紧素转换酶抑制剂、β受体阻滞剂及硝酸酯类药物),治疗组在对照组基础上口服糖心合剂4粒,每日3次,共治疗12周。比较两组的临床疗效,心脏超声检测治疗前后左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)、左室射血分数(EF)、左室短轴缩短率(FS)、E/A值,评价心功能。结果治疗组的临床总有效率为89.65%,对照组为60.00%,治疗组优于对照组(P<0.05);治疗组心功能各项指标均较治疗前明显改善,差异有统计学意义(P<0.05或P<0.01);对照组治疗后EF、FS较前有所好转(P<0.01),治疗组改善程度优于对照组(P<0.05或P<0.01)。结论糖心合剂能够改善2型糖尿病合并心功能不全患者的心功能。     

植物日光性皮炎一例

患者,女,49岁.大量进食"灰灰菜(藜叶)"及"曲菜(苣荬菜)"约4 h后,暴露于强烈日晒下约1 h,面颈部、双手背先后出现水肿性红斑伴瘙痒,皮损迅速发展,呼吸困难、意识恍惚.治疗:嘱其严格避光,给予泼尼松片、西替利嗪口服等,局部3％硼酸溶液湿敷,夫西地酸乳膏、曲咪新乳膏外用.1个月后随访,患者面颈部痂皮完全脱落,皮疹...     

多层螺旋CT重建术在周围型小肺癌诊断中的应用

目的探讨多层螺旋CT后处理技术在周围型小肺癌诊断中的价值。方法收集经病理证实的周围型小肺癌（直径≤20 mm）36例。全部行MSCT扫描,分别以MPR、SSD、VR技术进行重建,并与横断面薄层扫描对比分析。结果MPR在显示血管集束征、分叶征、细短毛刺征,SSD显示胸膜凹陷,VR显示血管集束征、分叶征中的敏感性均较横断薄层扫描提高10%以上。结论MSCT后处理技术在显示肺癌征象上较横断面图像具有较高的价值,特别是多种后处理方法联合应用对诊断周围型小肺癌意义重大。     

普拉洛芬滴眼液在LASEK术中的应用

目的：观察普拉洛芬在LASEK术中应用的效果。

方法：选取2011-05/08来我院行LASEK手术患者56例112眼。随机分为实验组(使用普拉洛芬)和对照组。对两组患者术后的刺激症状进行1wk对比研究。

结果：两组在控制术后刺激症状方面有明显差异。实验组未见特殊的不良反应及并发症。

结论：普拉洛芬眼液是控制LASEK术后刺激症状的安全有效的药物。