神经梅毒的MRI表现

目的：寻找提示神经梅毒的MRI表现的特点。方法：回顾性分析8例经临床证实的神经梅毒患者的MRI表现,并归纳其特点。结果：所有患者MRI表现为病变广泛弥散,至少累及2个脑叶以上,表现为T1WI低信号,T2WI高信号影,FLAIR上呈高信号。5例同时累及幕上、幕下,6例累及灰白质,所有病例DWI呈等或稍高信号影,均存在脑萎缩征象。其中5例行增强扫描,所见病变均未见明显强化。结论：MRI表现：同时累及幕上、幕下及灰白质,DWI上为等或稍高信号及同时合并脑萎缩,增强扫描未见明显强化者,应注意排除神经梅毒。     

子宫颈癌的MRI诊断及分期

目的探讨MRI分期在子宫颈癌诊断和治疗中的临床意义。方法对我院妇科子宫颈活检证实的72例子宫颈癌患者于临床症状出现后行MRI检查。由二位MRI诊断医师分别对每例患者的图像资料进行分析记录，包括病灶的部位、大小、浆膜有否受累、是否侵及子宫旁、周围器官是否侵及和淋巴结肿大情况，并依据Sironi’s提出的分期方法进行了MRI分期。根据MRI的分期结果，51例子宫颈癌接受了手术治疗，并将手术后病理分期结果与MRI的分期结果进行了比较。结果72例活检证实的子宫颈癌，MRI均发现了病灶。51例手术病例中，44例的MRI分期结果与术后病理分期结果相吻合。总的MRI分期的符合率为86．4％。结论对Ⅰa期以上的子宫颈癌，MRI均可以显示病灶，并可以进行合理分期。如把子宫颈癌的MRI分期合理应用于子宫颈癌的诊治，对其治疗方法的选择有重要意义。     

Lipomatous Hypertrophy of the Interatrial Septum: A Rare Cause of Right Ventricular Impairment

Abstract We report a case of a 70‐year‐old woman admitted with symptoms of decompensated heart failure. Magnetic resonance imaging revealed lipomatous hypertrophy of the interatrial septum with partial upper right atrial inflow obstruction, partial obstruction of the right ventricular outflow tract, and excessive accumulation of adipose tissue in the pericardial space. The patient underwent excision of the septal lipomatous mass, which relieved the right ventricular outflow obstruction. (J Card Surg 2010;25:171‐174)     

脑膜尾征”：与脑膜瘤相关的MR强化表现

目的分析脑膜瘤脑膜尾征的MR表现及组织学特点。方法对32例脑膜瘤患者均行MR平扫及增强扫描。结果32例34个脑膜瘤病灶中有23个病灶（67.6%）显示脑膜尾征,且与肿瘤的大小与位置无关。结论脑膜尾征是脑膜瘤在MR增强扫描时较常见和特有的表现,而且脑膜尾征与肿瘤侵犯脑膜部分相关。     

双源CT灌注成像在肝转移瘤TACE前后的临床应用研究

目的通过双源CT灌注成像观察肝转移瘤的血流动力学特征、肝动脉栓塞化疗(transcatheter hepatic arterial chemoembolization,TACE)后肝转移瘤灌注参数特征和改变,以及双源CT灌注成像评价TACE的效果。方法应用第二代西门子双源CT对28例肝转移瘤患者在TACE前和TACE后25~35d行CT灌注扫描检查。测量治疗前后肝转移瘤和周围正常肝实质的CT灌注参数。结果 TACE前肝转移瘤CT灌注参数肝动脉灌注量(hepatic arterial perfusion,ALP)、肝动脉灌注指数(hepatic perfusion index,HPI)、门静脉灌注量(portal vein perfusion,PVP)均大于周围正常肝实质,血流量(blood flow,BF)、血容量(blood volumn,BV)、表面通透性(permeability surface,PMB)均小于周围正常肝实质(P<0.05)。TACE后肝转移瘤CT灌注参数BF、BV、PMB、ALP均较TACE前减低,PVP、HPI均较TACE前增高(P<0.05);TACE后肝转移瘤PVP、HPI均大于周围正常肝实质,BF、BV、PMB、ALP均小于周围正常肝实质(P<0.05)。结论第二代双源CT灌注成像能够客观反映肝转移瘤的血流动力学特征,并能够评价TACE前后肝转移瘤的血供变化,为临床治疗提供有价值的指导。     

An ultra-sensitive T2-weighted MR contrast agent based on Gd3+ ion chelated Fe3O4 nanoparticles

An ultra-sensitive T₂-weighted MR imaging contrast agent was prepared based on Fe₃O₄ nanoparticles and Gd³⁺ ions (Fe₃O₄@Gd). Amino modified Fe₃O₄ nanoparticles were conjugated to diethylenetriamine pentaacetic acid, and finally coordinated with Gd³⁺ ions. The nanoparticles had a uniform morphology with a size of 100 nm and a Gd/Fe mass ratio of 1/110. The r₂ (transverse relaxivity) of the Fe₃O₄ nanoparticles increased from 131.89 mM⁻¹ s⁻¹ to 202.06 mM⁻¹ s⁻¹ after coordination with Gd³⁺ ions. MR measurements showed that the aqueous dispersion of Fe₃O₄@Gd nanoparticles had an obvious concentration-dependent negative contrast enhancement. Hepatoma cells were selected to test the cytotoxicity and MR imaging effect. The application of Fe₃O₄@Gd nanoparticles as contrast agents was also exploited in vivo for T₂-weighted MR imaging of rat livers. All the results showed the effectiveness of the nanoparticles in MR diagnosis.

An ultra-sensitive T₂-weighted MR imaging contrast agent was prepared based on Fe₃O₄ nanoparticles and Gd³⁺ ions (Fe₃O₄@Gd).