全文获取类型
收费全文 | 2466篇 |
免费 | 132篇 |
国内免费 | 84篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 18篇 |
妇产科学 | 40篇 |
基础医学 | 370篇 |
口腔科学 | 41篇 |
临床医学 | 303篇 |
内科学 | 175篇 |
皮肤病学 | 14篇 |
神经病学 | 159篇 |
特种医学 | 80篇 |
外国民族医学 | 1篇 |
外科学 | 146篇 |
综合类 | 252篇 |
现状与发展 | 2篇 |
预防医学 | 284篇 |
眼科学 | 18篇 |
药学 | 371篇 |
6篇 | |
中国医学 | 316篇 |
肿瘤学 | 79篇 |
出版年
2024年 | 2篇 |
2023年 | 28篇 |
2022年 | 41篇 |
2021年 | 110篇 |
2020年 | 104篇 |
2019年 | 88篇 |
2018年 | 109篇 |
2017年 | 65篇 |
2016年 | 71篇 |
2015年 | 80篇 |
2014年 | 168篇 |
2013年 | 162篇 |
2012年 | 189篇 |
2011年 | 160篇 |
2010年 | 151篇 |
2009年 | 138篇 |
2008年 | 91篇 |
2007年 | 175篇 |
2006年 | 145篇 |
2005年 | 84篇 |
2004年 | 75篇 |
2003年 | 73篇 |
2002年 | 70篇 |
2001年 | 57篇 |
2000年 | 32篇 |
1999年 | 52篇 |
1998年 | 40篇 |
1997年 | 29篇 |
1996年 | 28篇 |
1995年 | 25篇 |
1994年 | 23篇 |
1993年 | 14篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1990年 | 1篇 |
排序方式: 共有2682条查询结果,搜索用时 15 毫秒
61.
62.
64.
《The journal of sexual medicine》2015,12(6):1481-1489
IntroductionThe conception of collagenase Clostridium histolyticum (CCH) as treatment for Peyronie's disease (PD) was a vital first step in providing a nonsurgical, minimally invasive FDA-approved treatment for men with PD.AimTo review the origins, clinical research history, and ultimately FDA approval of collagenase as PD treatment.MethodsA PubMed search using (Peyronie's or Peyronie) AND collagenase, and limited to clinical research studies, returned nine papers that were examined in the current review.ResultsCollagenase as a PD treatment arose in response to a lack of effective nonsurgical treatments and the incomplete understanding of underlying PD etiology. Awareness of dense collagen in PD scarring and parallel initial exploration of collagenase to treat herniated lumbar discs coincided with and inspired laboratory-based investigation of collagenase effects on excised PD plaque tissue. The foundational conceptual work and the critical development of purified injectable collagenase allowed the pursuit of clinical studies. Progression of clinical studies into large-scale robust trials culminated in two important outcomes: development of the first validated, PD-specific measure of psychosexual function, the Peyronie's Disease Questionnaire, and the first FDA-approved treatment for PD.ConclusionsCollagenase therapy began as an attempt to modify the structure of PD-related tunica albuginea scarring, despite the lack of a fundamental understanding of the scar's origin. If we wish to advance PD treatment beyond this first effective step, the future needs to bring us full circle to the starting point: We need a greater understanding of the control of collagen deposition and wound healing in men with PD. Gelbard MK, Chagan L, and Tursi JP. Collagenase Clostridium histolyticum for the treatment of Peyronie's disease: The development of this novel pharmacologic approach. J Sex Med 2015;12:1481–1489. 相似文献
65.
Juan He Man-Si Yang Wen-Xiang Wang Zheng-Hui Li Waill Ahmed Mohamed Elkhateeb Ting-Chi Wen Hong-Lian Ai Tao Feng 《RSC advances》2018,9(1):128
A bioguided separation on the cultures of the potato endophytic fungus Bipolaris eleusines led to the isolation of two anti-phytopathogenic (Alternaria solani) sesquiterpenoid-xanthone adducts, namely bipolins I and J (1 and 2). Their structures were established via extensive spectroscopic analysis. Compounds 1 and 2 exhibit potent inhibitory activity against A. solani with MIC values of 8 and 16 μg mL−1, respectively.Two sativene sesquiterpenoid-xanthone adducts from potato endophytic fungus Bipolaris eleusines 相似文献
66.
Derong Luo Yi Zeng Xiong Chen Ping Xia Guangyong Xie Qingliang You Li Zhang Tingcheng Li Xiangdan Li Aiqing Zhang 《RSC advances》2018,8(13):6954
Binuclear and multinuclear complexes have attracted much attention due to their unique catalytic performances for olefin polymerization compared with their mononuclear counterparts. In this work, a series of phenyl-bridged bis-β-carbonylenamine [O−NSR] (R = alkyl or phenyl) tridentate ligands and their binuclear titanium complexes (Ti2L1–Ti2L5) were synthesized and characterized by 1H NMR, 13C NMR, FTIR and elemental analysis. The molecular structure of ligand L2 (R = nPr) and its corresponding Ti complex Ti2L2 were further investigated by single-crystal X-ray diffraction, which showed that each titanium coordinated with six atoms to form a distorted octahedral configuration along with the conversion of the ligand from β-carbonylenamine to β-imino enol form. Under the activation of MMAO, these complexes catalyzed ethylene polymerization and ethylene/α-olefin copolymerization with extremely high activity (over 106 g mol (Ti)−1 h−1 atm−1) to produce high molecular weight polyethylene. At the same time, wider polydispersity as compared with the mononuclear counterpart TiL6 was observed, indicating that two active catalytic centers may be present, consistent with the asymmetrical crystal structure of the binuclear titanium complex. Furthermore, these complexes possessed better thermal stability than their mononuclear analogues. Compared with the complexes bearing alkylthio sidearms, the complex Ti2L5 bearing a phenylthio sidearm exhibited higher catalytic activity towards ethylene polymerization and produced polyethylene with much higher molecular weight, but with an appreciably lower 1-hexene incorporation ratio. Nevertheless, these bis-β-carbonylenamine-derived binuclear titanium complexes showed much higher ethylene/1-hexene copolymerization activity and 1-hexene incorporation ratios as compared with the methylene-bridged bis-salicylaldiminato binuclear titanium complexes, and the molecular weight and 1-hexene incorporation ratio could be flexibly tuned by the initial feed of α-olefin commoners and catalyst structures.Phenyl-bridged bis-β-carbonylenamine binuclear titanium complexes were synthesized, characterized and used to catalyze ethylene (co)polymerization with extremely high activity. 相似文献
67.
W. W. He X. H. Yan Y. M. Liang Y. F. Long C. Pan J. L. Zhao L. Chen W. Xiong Q. X. Liu 《RSC advances》2018,8(22):12146
Flexible transparent electrodes (TEs) are important for new electronic devices. This paper reports a scalable, cost effective Ag nanowires (AgNWs) TE, which is made of a SnO2·xH2O and AgNWs composite layer and a flexible polyethylene terephthalate (PET) bottom layer by a solution method at room temperature. The AgNWs/SnO2·xH2O composite TEs reveal a significant reduction of four orders in magnitude of sheet resistance, from 90 kΩ sq−1 to 12 Ω sq−1, while retaining transmittance of about 92% at 550 nm. This could be owing to the significant reduction of contact resistance for the weld-like junction of bound AgNWs. Compared with others, this method is characterized by filling gaps of the silver nanowire network with SnO2·xH2O. In addition, the adhesive forces between the AgNWs and the substrate are improved. This could be attributed to strong adhesion of SnO2·xH2O with the substrate. Moreover, this foldable transparent electrode is applicable for any non-planar surfaces and ultimately for future wearable optoelectronic devices.This paper reports one of a scalable, cost effective Ag nanowires (AgNWs) TE, which reveals a significant reduction of four orders in magnitude of sheet resistance, from 90 kΩ sq−1 to 12 Ω sq−1, while keep transmittance of about 92% at 550 nm. 相似文献
68.
Qijun Wang Shu Zhou Song Xiao Feifei Wei Xuezhu Zhao June Qu Hairen Wang 《RSC advances》2018,8(27):14775
Perovskites, which have excellent electrocatalytic properties, are promising for use in heterogeneous catalysis. However, the design and development of green and effective electrocatalysts for environmental water treatment remains an arduous challenge. To overcome such difficulties, we present a facile sol–gel method for the design and preparation of a series of perovskite-activated carbon (AC) composites (La1−xNdxFeO3@AC) for the degradation of methyl orange (MO) by heterogeneous electro-Fenton reactions. Furthermore, the as-made La0.6Nd0.4FeO3@AC composite anode had the strongest oxidation ability and stability, with MO wastewater and COD removal rates reaching 99.81% and 96.66% within 10 minutes, respectively. As far as we know, the La1−xNdxFeO3@AC composites can be regarded as a series of the most effective catalysts for the degradation of MO to date.We present a facile sol–gel method for the design and preparation of a series of perovskite-activated carbon composites (La1−xNdxFeO3@AC) for the degradation of methyl orange. 相似文献
69.
70.
A valid method based on heat-assisted slurry sampling graphic furnace atomic absorption spectrometry (HASS-GFAAS) was developed for the accurate determination of trace Pb in food standard reference materials (SRMs). The HASS technique significantly improved Pb recovery and precision compared to conventional slurry sampling techniques. The optimized HASS procedure was performed as follows: first, the sample (particle size ≤ 150 μm) was diluted with 0.05% (v/v) Triton X-100 containing 2% HNO3 and 1% H2O2 followed by heating for 20 min at 120 °C on a heating block. Next, the obtained slurry was sonicated in an autosampler cup, and finally, the slurry was introduced into a graphite tube and analyzed by the GFAAS with a Pb electrodeless discharge lamp (EDL). Calibration with aqueous standard solutions was used for Pb determination in food samples. The characteristic mass and limit of detection for Pb based on the integrated absorbance for a 2% (m/v) sample were 12 ± 0.6 pg and 0.003 mg kg−1, respectively. The accuracy (95.1–102% recovery) and good precision (0.1–3.6%) of this procedure are illustrated by the results obtained for the 12 food reference materials. The proposed method is suitable for determination of trace Pb in solid food samples. 相似文献