全文获取类型
收费全文 | 5706篇 |
免费 | 255篇 |
国内免费 | 23篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 113篇 |
妇产科学 | 112篇 |
基础医学 | 730篇 |
口腔科学 | 66篇 |
临床医学 | 321篇 |
内科学 | 1467篇 |
皮肤病学 | 171篇 |
神经病学 | 439篇 |
特种医学 | 134篇 |
外科学 | 1038篇 |
综合类 | 19篇 |
一般理论 | 1篇 |
预防医学 | 93篇 |
眼科学 | 42篇 |
药学 | 292篇 |
中国医学 | 19篇 |
肿瘤学 | 904篇 |
出版年
2023年 | 48篇 |
2022年 | 21篇 |
2021年 | 123篇 |
2020年 | 84篇 |
2019年 | 89篇 |
2018年 | 103篇 |
2017年 | 91篇 |
2016年 | 118篇 |
2015年 | 112篇 |
2014年 | 156篇 |
2013年 | 202篇 |
2012年 | 308篇 |
2011年 | 419篇 |
2010年 | 223篇 |
2009年 | 181篇 |
2008年 | 383篇 |
2007年 | 402篇 |
2006年 | 337篇 |
2005年 | 409篇 |
2004年 | 400篇 |
2003年 | 364篇 |
2002年 | 330篇 |
2001年 | 56篇 |
2000年 | 76篇 |
1999年 | 93篇 |
1998年 | 98篇 |
1997年 | 86篇 |
1996年 | 88篇 |
1995年 | 79篇 |
1994年 | 74篇 |
1993年 | 46篇 |
1992年 | 43篇 |
1991年 | 47篇 |
1990年 | 31篇 |
1989年 | 27篇 |
1988年 | 27篇 |
1987年 | 18篇 |
1986年 | 16篇 |
1985年 | 15篇 |
1984年 | 15篇 |
1983年 | 8篇 |
1982年 | 7篇 |
1981年 | 13篇 |
1980年 | 23篇 |
1979年 | 10篇 |
1978年 | 15篇 |
1977年 | 15篇 |
1975年 | 11篇 |
1973年 | 8篇 |
1971年 | 6篇 |
排序方式: 共有5984条查询结果,搜索用时 31 毫秒
21.
22.
Luong Dong Cao Ishiwada Naruhiko Takeda Nobue Kohno Yoichi 《Pediatrics international》2004,46(4):419-424
BACKGROUND: Haemophilus influenzae (H. influenzae) is the most frequent bacterial pathogen of respiratory tract infections in children. Detection of antimicrobial susceptibility of H. influenzae is necessary for institution of appropriate antibiotic treatments. METHODS: A total of 281 strains of H. influenzae isolated from sputum samples of 281 pediatric patients with respiratory tract infections were recruited for study. Antibiotic susceptibility was determined by assessing minimum inhibitory concentrations (MIC) of antimicrobial agents. MIC were measured by utility of Agar dilution susceptibility test. RESULTS: Of the total, 38 (13.5%) strains produced beta-lactamase (BLP), 56 (19.9%) strains were beta-lactamase non-producing, ampicillin resistant (BLNAR). The overall resistant proportion to ampicillin was 33.4%. The data indicated that sulbactam/ampicillin, cefotaxime, ceftriaxone and cefditoren are effective against BLP strains. In addition, a high prevalence of BLNAR H. influenzae strains was identified, with an overall isolation rate of 19.9%. Those strains mainly demonstrated intermediate level to ampicillin (ampicillin-MIC = 3.13 micro g/mL for most of BLNAR strains). However, antimicrobial activities of cefotaxime, ceftriaxone and cefditoren against those strains were slightly diminished. Recovery rate of BLP strains was varied by years, peaking at 19.5%. In particular, a trend of yearly increase in frequency of BLNAR strains was observed. CONCLUSION: Frequency of BLNAR strains causing respiratory infections has been dramatically increasing, which can diminish antibiotic activities of not only ampicillin but also of some cephems. 相似文献
23.
Yoichi Kikuchi Taku Sakurada Masato Suzuki Tomoyasu Hirano Katsuyuki Kusajima 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2004,52(8):375-378
Off-pump coronary artery bypass grafting has become an attractive surgical alternative for myocar-dial revascularization because
of the advantage of myocardial protection and other benefits of patients. However, it is still regarded as a controversial
treatment for the coronary artery disease accompanied by atrial fibrillation (AF). A significant number of patients in need
of coronary revascularization have chronic AF. Although the Cox-Maze III procedure is the gold standard for the surgical treatment
of AF, few of these patients undergo AF operations at the time of their coronary bypass grafting. We report herein a case
of the pulmonary vein isolation to eliminate the AF by means of epicardial radiofrequency ablation combined with 2 vessels
coronary artery bypass grafting on the beating heart with the aid of cardiopulmonary bypass. 相似文献
24.
Takafumi Nagaoka Yoichi Katayama Toshikazu Kano Kazutaka Kobayashi Hideki Oshima Chikashi Fukaya Takamitsu Yamamoto 《Neuromodulation》2007,10(3):206-215
Objective. Employing [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) to assess the correlation between the effect of deep brain stimulation (DBS) on the subthalamic nucleus (STN) and the regional cerebral metabolic rate of glucose (rCMRGlc) in advanced Parkinson's disease patients (N = 8). Materials and Methods. On the basis of patients’ diary records, we performed FDG‐PET during the off‐period of motor activity with on‐ or off‐stimulation by STN‐DBS on separate days and analyzed the correlation between changes in motor symptoms and alterations in the rCMRGlc. Result. When FDG‐PET was performed, the motor score on the unified Parkinson's disease rating scale (UPDRS) was 64% lower with on‐stimulation than with off‐stimulation (p < 0.001, Wilcoxon single‐rank test). STN‐DBS increased the rCMRGlc in the posterior part of the right middle frontal gyrus, which corresponded to the premotor area, and the right anterior lobe of the cerebellum (p < 0.005, paired t‐test). No region exhibited a decrease in rCMRGlc. Among the items of the UPDRS motor score, the changes in resting tremor and rigidity of the left extremities showed a significant correlation with the changes in rCMRGlc observed in the right premotor area (p < 0.02 and p < 0.05, respectively, Spearman's rank correlation). Conclusions. STN‐DBS either activates the premotor area or normalizes the deactivation of the premotor area. These FDG‐PET findings obtained are consistent with the idea that STN‐DBS modifies the activities of neural circuits involved in motor control. 相似文献
25.
A 68‐year‐old man, who had no remarkable past medical history, was referred to a hospital because of disorientation and right‐sided hemiparesis. On magnetic resonance imaging, a contrast‐enhanced tumor in the left frontal lobe with perifocal edema was noted. He underwent left frontal lobectomy. Microscopic examination revealed infiltrative atypical astrocytes showing increased cellularity, distinct nuclear atypia, and many mitotic figures, while microvascular proliferation and necrosis were absent. Thus, the tumor was histologically diagnosed as anaplastic astrocytoma. It was of note that cytoplasmic eosinophilic granules were observed in approximately 25% of neoplastic cells. The granules were positively immunostained with anti‐αB‐crystallin antibody, and the other histochemical and immunohistochemical results also corresponded to Rosenthal fibers. The MIB‐1 labeling index of the highest area of the tumor was 22%, while that of granular cells was 2.1%. An ultrastructural study revealed amorphous electron‐dense structures attached to intermediate filament bundles, compatible with Rosenthal fibers. Such structures are relatively common in oligodendroglial tumors; however, they are extremely rare in astrocytic tumors. Fluorescence in situ hybridization targeted against chromosome 1 failed to demonstrate allelic loss of the short arm. The present case should also be discriminated from granular cell astrocytoma. We review related literature and discuss the significance of granules in gliomas. 相似文献
26.
Risk of gallstones following gastrectomy in Japanese men 总被引:3,自引:0,他引:3
Yoichi Ikeda Koichi Shinchi Suminori Kono Kenji Tsuboi Keizo Sugimachi 《Surgery today》1995,25(6):515-518
The risk of gallstones developing after gastrectomy in middle-aged Japanese men was investigated in a study of 2,738 men aged between 48 and 56 years who underwent both gallbladder ultrasonography (US) and a barium study of the upper digestive tract. It was revealed that 61 men had gallstones, 37 had had their gallbladder removed previously, and 55 had a history of gastrectomy. The prevalence of gallstones was 3.5 times higher in the men who had previously undergone gastrectomy (7.7%) than in those who had not (2.2%) (P=0.03). Moreover, gallstones tended to be more prevalent in those who had undergone Billroth II gastrectomy (12.5%) compared with those who had undergone Billroth I gastrectomy (5.6%); however, the difference was not significant. These results indicate that gastrectomy using either Billroth I or Billroth II reconstruction predisposes to gallstone formation. Nevertheless, it was estimated that prior gastrectomy was responsible for no more than 5% of gallstones in the study population. 相似文献
27.
Reed Jon A.; Nador Roland G.; Spaulding David; Tani Yoichi; Cesarman Ethel; Knowles Daniel M. 《Blood》1998,91(10):3825-3832
28.
Hiroyoshi Suzuki Taisuke Otsuki Yuzo Iwasaki Ryuichi Katakura Hideshi Asano Mamoru Tadokoro Yoichi Suzuki Fumiaki Tezuka Hidehiro Takei 《Neuropathology》2002,22(1):40-47
The present case report describes a case of ganglioglioma with a distinct sarcomatous component in the left temporal lobe of a 59‐year‐old Japanese man. Neoplastic neuroglial tissue contained both benign and anaplastic glial components with a MIB‐1 labeling index of 0.1% and 12.0%, respectively. Sarcomatous tissue adjacent to the anaplastic glial tissue was dominated by pleomorphic fibroblastic cells with a MIB‐1 labeling index of 10.8%. They were immunoreactive for smooth muscle actin, type IV collagen, and alpha 1 antitrypsin, but not for desmin and CD34. Interestingly, some of the sarcomatous cells were double‐positive for smooth muscle actin and GFAP. The p53 protein had accumulated in the anaplastic astrocytes and sarcomatous cells, but direct DNA sequencing of PCR products failed to detect any mutation in the p53 gene (from exon 4 to exon 10). 相似文献
29.
Abdullah Bereket Thomas A. Wilson Sandra L. Blethen Yoichi Sakurai David N. Herndon Robert R. Wolfe Charles H. Lang 《Clinical endocrinology》1996,44(5):525-532
OBJECTIVE Little information is available regarding the regulation of serum acid-labile subunit (ALS) in human disease. We have studied alterations in serum ALS of the insulin-like growth factor (IGF) ternary complex in children with untreated insulin-dependent diabetes mellitus (IDDM) and subjects with severe burns before and after insulin therapy. In addition, we have investigated the effect of insulin plus GH on serum ALS in burn patients. DESIGN Serum samples were obtained from children with newly diagnosed and untreated IDDM before the initiation of insulin therapy and 1 month thereafter. Serum samples were also obtained from adult patients with severe burns who were on a continuous infusion of a carbohydrate-rich enteral diet via nasogastric and duodenal catheters under basal conditions, after a 1-week period of continuous insulin infusion, and after an additional week of insulin plus recombinant GH. PATIENTS Twenty children and adolescents with untreated IDDM, aged 1.2–16 years, and 6 young adult patients with severe burns aged 17–28 years were studied longitudinally. Control sera were obtained from age, sex and pubertal status matched subjects (for children with IDDM) and from fed healthy adults. MEASUREMENTS Serum insulin, GH, cortisol and IGF-I were measured by radioimmunoassay, and serum ALS levels were assessed by Western immunoblot before and after treatment periods. RESULTS Serum ALS levels were lower in untreated children with IDDM (69 ± 6% of control children). Insulin therapy significantly increased serum ALS (79 ± 5%, P<0.05) in these children. Patients with severe burns also had lower serum ALS levels (79 ± 10% of control adults). After one week of insulin therapy serum ALS levels increased to 90 ± 15% of control values (P<0.05). Addition of GH to insulin therapy for another week did not significantly further increase serum ALS levels (95 ± 27%). Serum IGF-I concentrations increased nearly 2.5-fold in diabetic subjects and fourfold in burn subjects at the end of the study periods. There were no proteolytic fragments of ALS in the sera studied. The deglycosylation pattern of ALS did not differ between diabetic and control sera. CONCLUSION Serum ALS levels were diminished in children with untreated IDDM and were partially restored after the initiation of insulin therapy. Serum ALS levels were also diminished in patients with severe burn injury and restored by insulin treatment. Addition of GH to insulin therapy did not significantly increase serum ALS levels over levels obtained during insulin therapy alone. These decreases in serum ALS were smaller than the decrease in serum IGF-I concentrations in both conditions, suggesting that IGF-I is the limiting factor for the ternary complex formation in the catabolic states. Insulin may regulate circulating ALS levels in catabolic states and helps to restore the IGF system. 相似文献
30.
Yonson Ku Masahiro Tominaga Takeshi Iwasaki Tetsushi Kitagawa Ichiro Maeda Masafumi Shiotani Shinya Kusunoki Yoko Maekawa Masahiro Samizo Takumi Fukumoto Yoshikazu Kuroda Shozo Hirota Yoichi Saitoh 《Surgery today》1996,26(5):305-313
The results of treating 12 consecutive patients with unresectable colorectal hepatic metastases with a hepatic arterial infusion of high-dose Adriamycin, 100–120 mg/m2, using hepatic venous isolation (HVI) and charcoal hemoperfusion (CHP) are reported herein. Adriamycin was administered over 5–15 min under extracorporeal drug elimination by HVI-CHP. HVI was percutaneously accomplished by either the double-balloon technique using a Fogarty occlusion catheter (8/22F) or a balloon-tipped catheter (16F). During the infusion, isolated hepatic venous blood was filtered by CHP and pumped into the left axillary vein. There were no lethal complications, and good hemodynamic tolerance to HVI-CHP was confirmed. Tumor liquefaction accompanied by a sharp decrease in serum carcinoembryonic antigen levels by more than 50% of pretreatment levels was observed in 6 of the 12 patients 1 month after treatment. Apart from chemical hepatitis, which developed in 11 (92%) of the patients, the Adriamycin toxicities were well controlled following the development of nausea and vomiting in 2 patients (17%), leukopenia <2,000/mm3 in 3 (25%), and gastric ulcer in 1 (8%). These results indicate that this method is a safe and useful procedure for otherwise hazardous high-dose intraarterial chemotherapy in patients with unresectable hepatic tumors. 相似文献