Moderne Therapie beim frühen Mammakarzinom

best practice onkologie - Moderne Therapieformen beim frühen Mammakarzinom beziehen sich nicht nur auf optimierte und innovative systemtherapeutische Interventionen, sondern beinhalten auch...     

Zervixkarzinom

The introduction of cytological screening has led to a reduction in the incidence of cervical cancer in Germany and there is reason to hope that human papillomavirus (HPV) inoculation will lead to a further reduction. In recent years there have also been technical and conceptual improvements even for the primary treatment of patients with manifest cancer. This article presents the current approaches in diagnostics and therapy and the contribution of magnetic resonance imaging (MRI) and positron emission tomography (PET) for pretherapeutic staging and minimally invasive techniques for reduction of operative trauma will be discussed. Total mesometrial resection (TMMR) is a new but controversial surgical technique based on a tumor spread model within morphological entities. Initial data indicate that TMMR in combination with therapeutic lymphadenectomy guarantees local and regional control even in cases with histopathological risk factors.     

Uterine Leiomyome

Myomas of the uterus are benign tumors which very often occur among fertile women. In addition to surgical intervention other treatment modalities include medicinal (endocrine) and radiological interventions. This overview will review, discuss and evaluate these modalities.     

Survivors of primary breast cancer 5 years after surgery: follow-up care,long-term problems,and treatment regrets. Results of the prospective BRENDA II-study

Archives of Gynecology and Obstetrics - This study aims to answer the questions where breast cancer patients in Germany receive follow-up care (with what types of doctors) and what are the...     

Mastectomy trends for early-stage breast cancer: A report from the EUSOMA multi-institutional European database

IntroductionRecent single-institution reports have shown increased mastectomy rates during the last decade. Further studies aiming to determine if these reports could be reflecting a national trend in the United States of America (US) have shown conflicting results. We report these trends from a multi-institutional European database.Patients and methodsOur source of data was the eusomaDB, a central data warehouse of prospectively collected information of the European Society of Breast Cancer Specialists (EUSOMA). We identified patients with newly diagnosed unilateral early-stage breast cancer (stages 0, I or II) to examine rates and trends in surgical treatment.ResultsA total of 15,369 early-stage breast cancer cases underwent surgery in 13 Breast Units from 2003 to 2010. Breast conservation was successful in 11,263 cases (73.3%).Adjusted trend by year showed a statistically significant decrease in mastectomy rates from 2005 to 2010 (p = 0.003) with a progressive reduction of 4.24% per year. A multivariate model showed a statistically significant association of the following factors with mastectomy: age <40 or ⩾70 years, pTis, pT1mi, positive axillary nodes, lobular histology, tumour grade II and III, negative progesterone receptors and multiple lesions.ConclusionOur study demonstrates that a high proportion of patients with newly diagnosed unilateral early-stage breast cancer from the eusomaDB underwent breast-conserving surgery. It also shows a significant trend of decreasing mastectomy rates from 2005 to 2010. Moreover, our study suggests mastectomy rates in the population from the eusomaDB are lower than those reported in the US.