全文获取类型
收费全文 | 251215篇 |
免费 | 54226篇 |
国内免费 | 5296篇 |
专业分类
耳鼻咽喉 | 3715篇 |
儿科学 | 6590篇 |
妇产科学 | 3001篇 |
基础医学 | 40941篇 |
口腔科学 | 8702篇 |
临床医学 | 30951篇 |
内科学 | 51253篇 |
皮肤病学 | 11497篇 |
神经病学 | 25515篇 |
特种医学 | 11559篇 |
外国民族医学 | 24篇 |
外科学 | 35367篇 |
综合类 | 11414篇 |
现状与发展 | 17篇 |
一般理论 | 56篇 |
预防医学 | 14524篇 |
眼科学 | 5826篇 |
药学 | 22731篇 |
64篇 | |
中国医学 | 5653篇 |
肿瘤学 | 21337篇 |
出版年
2024年 | 184篇 |
2023年 | 1484篇 |
2022年 | 2120篇 |
2021年 | 8529篇 |
2020年 | 9071篇 |
2019年 | 14882篇 |
2018年 | 15035篇 |
2017年 | 15439篇 |
2016年 | 16868篇 |
2015年 | 19115篇 |
2014年 | 20574篇 |
2013年 | 21974篇 |
2012年 | 19526篇 |
2011年 | 19391篇 |
2010年 | 17935篇 |
2009年 | 12870篇 |
2008年 | 12681篇 |
2007年 | 11293篇 |
2006年 | 10430篇 |
2005年 | 9652篇 |
2004年 | 8093篇 |
2003年 | 7549篇 |
2002年 | 6639篇 |
2001年 | 5434篇 |
2000年 | 4778篇 |
1999年 | 3681篇 |
1998年 | 1736篇 |
1997年 | 1448篇 |
1996年 | 1054篇 |
1995年 | 1056篇 |
1994年 | 811篇 |
1993年 | 613篇 |
1992年 | 1128篇 |
1991年 | 983篇 |
1990年 | 876篇 |
1989年 | 791篇 |
1988年 | 640篇 |
1987年 | 638篇 |
1986年 | 488篇 |
1985年 | 470篇 |
1984年 | 320篇 |
1983年 | 223篇 |
1982年 | 166篇 |
1981年 | 193篇 |
1980年 | 154篇 |
1979年 | 254篇 |
1978年 | 176篇 |
1976年 | 148篇 |
1974年 | 162篇 |
1973年 | 144篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
71.
Peng‐fei Lei Shi‐long Su Ling‐yu Kong Cheng‐gong Wang Da Zhong Yi‐he Hu 《Orthopaedic Surgery》2019,11(5):914-920
Three‐dimensional (3D) printing technology, virtual reality, and augmented reality technology have been used to help surgeons to complete complex total hip arthroplasty, while their respective shortcomings limit their further application. With the development of technology, mixed reality (MR) technology has been applied to improve the success rate of complicated hip arthroplasty because of its unique advantages. We presented a case of a 59‐year‐old man with an intertrochanteric fracture in the left femur, who had received a prior left hip fusion. After admission to our hospital, a left total hip arthroplasty was performed on the patient using a combination of MR technology and 3D printing technology. Before surgery, 3D reconstruction of a certain bony landmark exposed in the surgical area was first performed. Then a veneer part was designed according to the bony landmark and connected to a reference registration landmark outside the body through a connecting rod. After that, the series of parts were made into a holistic reference registration instrument using 3D printing technology, and the patient's data for bone and surrounding tissue, along with digital 3D information of the reference registration instrument, were imported into the head‐mounted display (HMD). During the operation, the disinfected reference registration instrument was installed on the selected bony landmark, and then the automatic real‐time registration was realized by HMD through recognizing the registration landmark on the reference registration instrument, whereby the patient's virtual bone and other anatomical structures were quickly and accurately superimposed on the real body of the patient. To the best of our knowledge, this is the first report to use MR combined with 3D printing technology in total hip arthroplasty. 相似文献
72.
73.
Responsive feeding (RF) has been recognized as necessary to prevent all forms of malnutrition including stunting and childhood obesity. Specific RF guidelines have been developed, but it is unclear how RF behaviours can be monitored systematically. Therefore, developing valid and reliable abbreviated and pragmatic RF scales is an important global priority. This is challenging, as RF is a construct with multiple dimensions including recognizing and responding to hunger and satiety cues, providing a nurturing environment during feeding episodes, and understanding how feeding needs evolve as a function of the developmental stage of the young child. Further, RF is embedded within the responsive parenting framework that in addition to RF includes sleep, soothing and play routines and the interconnections between them. A recent pioneer study conducted in a rural area of Cambodia validated an 8‐item RF scale through direct feeding observations of 6‐ to 23‐month‐old infants at home, as part of two cross‐sectional surveys conducted before and after a complementary feeding intervention. It is important for similar research to be conducted elsewhere to find out if it is possible or not to develop a core RF scale that is valid and reliable and that has adequate specificity and sensitivity for application in community studies and population surveys globally. As highlighted in this article, different definitions of RF have been used in the field; thus, it is important to reach consensus on a single definition to help move this research area forward. 相似文献
74.
75.
Guo-Chao Zhong Yang Peng Kang Wang Lun Wan You-Qi-Le Wu Fa-Bao Hao Jie-Jun Hu Hai-Tao Gu 《International journal of cancer. Journal international du cancer》2020,147(6):1577-1586
Epidemiological studies on magnesium intake and primary liver cancer (PLC) are scarce, and no prospective studies have examined the associations of magnesium intake with PLC incidence and mortality. We sought to clarify whether higher magnesium intake from diet and supplements was associated with lower risks of PLC incidence and mortality in the US population. Magnesium intake from diet and supplements was evaluated through a food frequency questionnaire in a cohort of 104,025 participants. Cox regression was employed to calculate hazard ratios for PLC incidence and competing risk regression was employed to calculate subdistribution hazard ratios for PLC mortality. Restricted cubic spline regression was employed to test nonlinearity. We documented 116 PLC cases during 1,193,513.5 person-years of follow-up and 100 PLC deaths during 1,198,021.3 person-years of follow-up. Total (diet + supplements) magnesium intake was found to be inversely associated with risks of PLC incidence (hazard ratiotertile 3 vs. 1: 0.44; 95% confidence interval: 0.24, 0.80; ptrend = 0.0065) and mortality (subdistribution hazard ratiotertile 3 vs. 1: 0.37; 95% confidence interval: 0.19, 0.71; ptrend = 0.0008). Similar results were obtained for dietary magnesium intake. Nonlinear inverse dose–response associations with PLC incidence and mortality were observed for both total and dietary magnesium intakes (all pnonlinearity < 0.05). In summary, in the US population, a high magnesium intake is associated with decreased risks of PLC incidence and mortality in a nonlinear dose–response manner. These findings support that increasing the consumption of foods rich in magnesium may be beneficial in reducing PLC incidence and mortality. 相似文献
76.
Bhavana Pothuri Allison L. Brodsky Joseph A. Sparano Stephanie V. Blank Mimi Kim Dawn L. Hershman Amy Tiersten Brian F. Kiesel Jan H. Beumer Leonard Liebes Franco Muggia 《Cancer chemotherapy and pharmacology》2020,85(4):741-751
Poly(ADP-ribosyl) polymerases (PARPs) are nuclear enzymes with roles in DNA damage recognition and repair. PARP1 inhibition enhances the effects of DNA-damaging agents like doxorubicin. We sought to determine the recommended phase two dose (RP2D) of veliparib with pegylated liposomal doxorubicin (PLD) in breast and recurrent gynecologic cancer patients. Veliparib and PLD were administered in a standard phase 1, 3 + 3 dose-escalation design starting at 50 mg veliparib BID on days 1–14 with PLD 40 mg/mg2 on day 1 of a 28-day cycle. Dose escalation proceeded in two strata: A (prior PLD exposure) and B (no prior PLD exposure). Patients underwent limited pharmacokinetic (PK) sampling; an expansion PK cohort was added. 44 patients with recurrent ovarian or triple negative breast cancer were enrolled. Median age 56 years; 23 patients BRCA mutation carriers; median prior regimens four. Patients received a median of four cycles of veliparib/PLD. Grade 3/4 toxicities were observed in 10% of patients. Antitumor activity was observed in both sporadic and BRCA-deficient cancers. Two BRCA mutation carriers had complete responses. Two BRCA patients developed oral squamous cell cancers after completing this regimen. PLD exposure was observed to be higher when veliparib doses were > 200 mg BID. The RP2D is 200 mg veliparib BID on days 1–14 with 40 mg/m2 PLD on day 1 of a 28-day cycle. Anti-tumor activity was seen in both strata. However, given development of long-term squamous cell cancers and the PK interaction observed, efforts should focus on other targeted combinations to improve efficacy. 相似文献
77.
Hyo-Kon Kim Sung-Han Ha Gi-Jun Lee Sun-O Yu Jung-Rae Kim 《Clinics in Orthopedic Surgery》2015,7(3):414-417
Synovial chondromatosis is a rare lesion in the wrist, but some cases in the distal radioulnar joint have been reported and previous case reports emphasize joint calcifications, shown on preoperative plain radiographs. We report an extremely uncommon case of synovial chondromatosis in the pisotriquetral joint, in which radiographs and magnetic resonance imaging did not demonstrate apparent calcified bodies. In our case, for the accurate diagnosis and treatment, surgical exploration of the joint and synovectomy with removal of loose bodies was performed. 相似文献
78.
79.
80.
Primary cutaneous anaplastic large cell lymphomas with 6p25.3 rearrangement exhibit particular histological features 下载免费PDF全文