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Manav Mehta Hanna Schell Carolin Schwarz Anja Peters Katharina Schmidt-Bleek Agnes Ellinghaus Hermann J. Bail Georg N. Duda Jasmin Lienau 《Archives of orthopaedic and trauma surgery》2011,131(1):121-129
Introduction
The objectives of this study were to (1) establish a reproducible atrophic non-union model in rats by creation of a segmental femoral bone defect that allows, (2) in-depth characterization of impaired healing, and (3) contrast its healing patterns to the normal course. Hypothesis was that a 5-mm bone defect in male rats would deviate from uneventful healing patterns and result in an atrophic non-union. 相似文献79.
ADF Winter School—An exciting concept of the Arbeitsgemeinschaft Dermatologische Forschung to connect young scientists and clinician scientists in Dermatology at the top of Germany 下载免费PDF全文
Amir S. Yazdi Meltem Barlin Katharina Böhm Fabian Gendrisch Saeedeh Ghorbanalipoor Stefanie Häberle Annamarie Hamel Svea Hüning Clemens Hüttner Irina Iwanova Theodora Kanaki Susanne Kimeswenger Nadine Lohmann Saira Munir Sukalp Muzumdar Manuel Pedro Pereira Patricia Peking Kristin Plesser Adriana Rendon Maximilian Rentschler Carolin Schlumprecht Anna Smorodchenko Martin Stock Jessica Tillmanns Ugur Uslu Kamran Ghoreschi Martin Glatz Stephan Grabbe Manfred Kunz Ralf Ludwig Karin Scharffetter‐Kochanek Karin Loser 《Experimental dermatology》2017,26(3):292-294
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Carolin Fella Greg F. Walker Manfred Ogris Ernst Wagner 《European journal of pharmaceutical sciences》2008,34(4-5):309-320
PEGylation which is reversed after the therapeutic agent reaches the target cell presents an attractive feature for drug, protein or nucleic acid delivery. Amine-reactive, endosomal pH cleavable polyethylene glycol aldehyde-carboxypyridylhydrazone, N-hydroxysuccinimide esters (PEG-HZN-NHS) were synthesized and applied for bioreversible surface shielding of DNA polyplexes. Monofunctional mPEG-HZN-NHS was synthesized by reacting succinimidyl hydraziniumnicotinate with mPEG-butyraldehyde (20 kDa). Bifunctional OPSS-PEG-HZN-NHS was synthesized analogously via a omega-2-pyridyldithio-PEG (10 kDa) propionaldehyde intermediate. Polyethylenimine (PEI) polyplexes were reacted with the pH-sensitive (mPEG-HZN-NHS) or the corresponding stable (mPEG-NHS) reagent. Both types of polyplexes remained shielded at pH 7.4 as demonstrated by particle size and zeta potential measurements after 4h of incubation at 37 degrees C. Polyplex deshielding at endosomal pH 5 was observed only with the mPEG-HZN-NHS shielded particles. This was confirmed by fluorescence correlation spectroscopy using the analogous Alexa-488 fluorescently labeled bifunctional PEGylation reagents. Luciferase gene transfections with epidermal growth factor (EGF) containing polyplexes using EGF-receptor overexpressing hepatoma HUH7 cells showed an up to 16-fold enhancement in gene expression with the reversibly shielded polyplexes as compared to stably shielded polyplexes. Consistently, the reversibly shielded polyplexes mediated also an enhanced tumor specific in vivo transgene expression after intravenous administration in a subcutaneous HUH7 tumor model in SCID mice. 相似文献