Katalaseuntersuchungen bei Neurosyphilis

Zusammenfassung Katalasebestimmungen im Liquor cerebrospinalis lassen erkennen, daß bei Syphilis — im Gegensatz zu nichtsyphilitischen Erkrankungen mit normalem und pathologischem Liquorbefund — sehr häufig das Auftreten dieses Fermentes nachweisbar ist. In besonders großer Zahl läßt sich bei den Fällen von Neurosyphilis ein positiver Katalasebefund feststellen, aus dem auf eine Steigerung der Reduktions-Oxydationsvorgänge im Zellstoffwechsel des Zentralnervensystems als Folge der Spirochätenwirkung geschlossen wird.Im Hautdialysat findet sich bei Syphilis — im Gegensatz zu hautgesunden und hautkranken Kontrollfällen, ferner von Fällen mit nichtsyphilitischen Erkrankungen der inneren Organe und des Zentralnervensystems — ein häufiger Katalaseschwund, wiederum in besonders großer Zahl bei den Fällen von Neurosyphilis.Diese gegensätzlichen Veränderungen in Liquor und Hautdialysat bei Neurosyphilis lassen die Möglichkeit von Beziehungen zwischen Haut und Gehirn vermuten, insofern als bei einer Steigerung der Reduktions-Oxydationsprozesse im Zentralnervensystem eine Erniedrigung derselben in der Haut stattfindet.Vortrag auf der 58. Versammlung Südwestdeutscher Neurologen und Psychiater am 10. VI. 1933 in Baden-Baden.     

Erwiderung

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Zur Kenntnis des angeborenen lymphangiektatischen Ödems

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The Relationship between Organizational Leadership for Safety and Learning from Patient Safety Events

ObjectiveTo examine the relationship between organizational leadership for patient safety and five types of learning from patient safety events (PSEs).ConclusionsWe find support for the relationship between patient safety leadership and patient safety behaviors such as learning from safety events. Formal leadership support for safety is of particular importance in small organizations where the economic burden of safety programs is disproportionately large and formal leadership is closer to the front lines.     

VDAC and ERα interaction in caveolae from human cortex is altered in Alzheimer's disease

Voltage-dependent anion channel (VDAC) is a mitochondrial porin also found in the neuronal membrane (pl-VDAC), where its function may be related to redox homeostasis and apoptosis. Murine models have evidenced pl-VDAC into caveolae in a complex with estrogen receptor alpha (mERα), which participates in neuroprotection against amyloid beta (Aβ), and whose integration into this hydrophobic domain remains unclear. Here, we have demonstrated in caveolae of human cortex and hippocampus the presence of pl-VDAC and mERα, in a complex with scaffolding caveolin-1 which likely provides mERα stability at the plasma membrane. In Alzheimer's disease (AD) brains, VDAC was accumulated in caveolae, and it was observed in dystrophic neurites of senile plaques, whereas ERα was expressed in astrocytes surrounding the plaques. Together with previous data in murine neurons demonstrating the participation of pl-VDAC in Aβ-induced neurotoxicity, these data suggest that the channel may be involved in membrane dysfunctioning observed in AD neuropathology.     

Verhandlungen Ärztlicher Gesellschaften

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Sj?gren syndrome in childhood

The authors report on the case of a 7-year-old girl with keratoconjunctivitis sicca. The diagnostic difficulties are discussed and the literary data on Sj?gren's syndrome in childhood are summarized.     

Zur Fermentibiologie und Fermentdiagnostik der Syphilis

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Retrospective assessment of potential interaction between levofloxacin and warfarin

Objective There is currently a controversy regarding interactions between levofloxacin and warfarin. The aim of this study was to determine the clinical relevance of this interaction in our setting. Setting A university hospital in Barcelona, Spain. Methods We carried out a retrospective evaluation of all patients hospitalized in our hospital during the period 2000–2005, selecting all those concomitantly treated with levofloxacin and warfarin for the study. The following data were compiled: demographic information, concomitant medication, comorbid conditions, and relevant analytical parameters, particularly the international normalized ratio (INR), including values taken before, during, and after concomitant administration of the two study drugs. Patients for whom INR values during concomitant administration were not available were excluded. Differences in INR before and during the potential interaction, and before and after the interaction were analyzed with the Wilcoxon t test using SPSS (V12.0). In addition, patients were stratified according to presence or not of toxic habits (smoking/alcohol consumption) to investigate the possible impact of these factors on the interaction under study. Results Among the 30 patients identified, 9 were excluded because INR data during concomitant administration of warfarin and levofloxacin were not available. Statistical analysis demonstrated significant increase in INR (P = 0.001) following addition of levofloxacin to warfarin therapy. Conclusions. The results of this study reaffirm the hypothesis that concomitant administration of levofloxacin and warfarin leads to INR increase; hence close monitoring of INR is advisable when patients are prescribed this combination of drugs. This paper has not been submitted elsewhere in similar form, and all authors have contributed significantly to the publication. All authors are aware of the submission and agree with it.