浅谈高校学报的出版工作

浅谈高校学报的出版工作《镇江医学院学报》编辑部赵峰，陈海林，汪玉芳自从北京大学从１９世纪末诞生以来，我国现代规模的高校已有１００多年历史了。高校学报自１９０６年苏州东吴大学创办《东吴月报》至今，也有９０年了。目前，我国的高等院校已有１０００多所，公开...     

非血缘关系造血干细胞移植61例分析

Objective To study the therapeutic effectiveness, associated complications and related factors of unrelated allogeneic hematopoietic stem cell transplantation (URD-HSCT). Methods Sixty-one patients with malignant hematological diseases received URD-HSCT. All cases were subjected to myeloablative or nonmyeloablative conditioning regimen according to primary diseases. Among 61 patients, 21 were donor-recipient 6/6 HLA-matched, 5 were 5/6 HLA antigen-matched, 24 were 1 HLA gene subtype-mismatched, 11 were 2 HLA gene subtype-mismatched. Eighteen patients were ABO-compatible with donors, while 43 ABO-incompatible with donors. The median of infused donor nucleated cells was 4.5×108/kg, and the median of CD34+ cells were 4.3×106/kg. The graft-versus-host disease (GVHD) prevention regimens were based on short-term MTX, cyclosporin A and mycophenolate mofetil (MMF) regimen. Forty-nine cases also received CD25 Mab on the day of transplantation, and the day 4 after transplantation. Nine cases were also administrated with antilymphocyte globulin (ALG) or antithymocyte globulin (ATG). Two cases received ALG and CD25 Mab. Results Among 61 patients, 59 cases were successfully engrafted, which was identified by blood type, chromosome test and DNA polymorphism. Twenty-three cases developed grade Ⅱ～Ⅳ acute GVHD. Twenty-five patients experienced chronic GVHD. Infection of bacterial and/or fungal within 100 days after URD-HSCT was documented in 48 cases. Thirty-six cases had cytomegalovirus infection. Major infection site was lower respiratory tract. Eighteen cases died after URD-HSCT, and the 2-year disease-free survival rate was (68.0±6.4)%. Among these 18 deaths, 12 cases died because of transplantation related complications with the transplantation related mortality (TRM) being 19.7 %, and the remaining 6 cases died of relapse with the relapse rate being 9. 8 %, respectively. Conclusions URD-HSCT is an effective therapeutic strategy for malignant hematopoietic diseases when related donor is not available Acute GVHD and infection are risk factors of therapeutic effect and prognosis after URD-HSCT. Early prediction and prevention of acute GVHD and infection are essential problems to overcome.     

甲氨蝶呤和复方米非司酮联用治疗异位妊娠的观察

目的:探讨甲氨蝶呤与复方米非司酮联合治疗异位妊娠的临床效果及护理措施。方法:将120例异位妊娠患者随机分为研究组和对照组,研究组采用甲氨蝶呤联合复方米非司酮治疗,对照组则采用甲氨蝶呤联合米非司酮治疗,分析其疗效。结果:观察组与对照组总有效率经统计学分析,差异有统计学意义(P<0.05)。研究组见1例肝功能异常,停药后好转;对照组有2例出现恶心、呕吐等胃肠道反应,停药后好转。药物副作用发生率组间无统计学差异(P>0.05)。结论:复方米非司酮联合甲氨蝶呤治疗异位妊娠,显著提高了治疗成功率,使用方便,值得临床推广应用。     

番茄红素蜂胶胶囊改善大鼠前列腺增生的实验研究

目的:探究番茄红素蜂胶胶囊对去势雄性大鼠前列腺增生的改善作用。方法:雄性去势SD大鼠,皮下注射丙酸睾丸素建立前列腺增生模型,灌胃给予番茄红素蜂胶胶囊,考察其对大鼠前列腺湿质量、前列腺体积、SOD、MDA水平及前列腺组织结构的影响。结果:高剂量番茄红素蜂胶胶囊能降低前列腺增生大鼠的前列腺指数(PI)及前列腺增生率(P0.05),并提高组织中SOD活力(P0.05)。结论:番茄红素蜂胶胶囊具有改善实验性前列腺增生的作用。     

医学论文参考文献著录的常见问题与正确使用

医学论文参考文献著录的常见问题与正确使用学报编辑部汪玉芳，陈海林参考文献是医学论文必不可少的一个重要组成部分，藉此可评估论文的学术水平，可追溯该一领域中的最新研究成果及其概况。便于信息的交流、存储、检索和利用。因此，参考文献的利用及著录规范化显得非常...     

应激时大鼠肝脏MDA含量及GSH—Px活性的变化

采用捆扎大鼠四肢淹水制成应激模型，观察大鼠应激１ｈ，２ｈ，３ｈ肝脏脂质过氧化形成和氧自由基清除系统活动的变化，结果显示：随着应激时间延长，肝脏中丙二醛（ＭＤＡ）含量逐步增加；同时，谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）的活性亦升高，但在应激３ｈ时ＧＳＨ－Ｐｘ活性有所下降，提示：应激时大鼠体内氧化和抗氧化能力均加强。     

ApoE3／2血浆表型脂蛋白对淋巴细胞的作用

采用生化和细胞培养的方法观察了ＡｐｏＥ３／２表型血浆脂蛋白不同组分对植物血凝素（ＰＨＡ）诱导的淋巴细胞增生的影响，以及低密度脂蛋白（ＬＤＬ）和极低密度脂蛋白（ＶＬＤＬ）对淋巴细胞产生白细胞介素２（ＩＬ－２）水平的影响。结果显示载脂蛋白Ｅ（ＡｐｏＥ）３／２表型血浆脂蛋白均不同程度地抑制ＰＨＡ诱导的淋巴细胞的体外增生，并且ＬＤＬ和ＶＬＤＬ均可明显降低淋巴细胞产生ＩＬ－２的水平。实验提示脂蛋白抑制淋巴细胞产生ＩＬ－２可能是引起体外淋巴细胞增生抑制的一个重要原因。     

66例成人骨髓增生异常综合征的诊断分析

目的进一步认识骨髓增生异常综合征（MDS）的临床和实验室诊断特点,提高诊断率。方法回顾性分析了本院收治的66例成人MDS患者的临床和实验室检查资料。结果66例患者中,3系均减少者36例、2系减少者21例,1系减少者9例。其中WBC增加者4例,PLT增加者6例,WBC和PLT均增加者1例。骨髓细胞学检查示增生活跃为51例,均有不同程度的病态造血表现,增生减低型MDS骨髓病理学较骨髓细胞学检测诊断率高。染色体核型异常检出4例（25％）,以RAEB居多。结论完善细胞学、骨髓涂片、病理学及遗传学的检查,对MDS的诊断、治疗方案和预后评估均具有重要的作用。     

DAE方案治疗急性非淋巴细胞性白血病81例

目的探讨DAE方案治疗急性非淋巴细胞白血病的疗效。方法以2006年6月至2012年6月在本科住院治疗的81例急性非淋巴细胞性白血病患者为研究对象,所有入选患者均采用诱导缓解的DAE方案。结果急性非淋巴细胞白血病患者分型以M5型最多;初治组患者完全缓解率（68.29%）高于复发组（52.50%）。结论 DAE方案在初治组的临床疗效较复发组好。