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排序方式: 共有346条查询结果,搜索用时 281 毫秒
61.
Augusto Faria Andrade Kleiton Silva Borges Veridiana Kiill Suazo Lenisa Geron Carolina Alves Pereira Corrêa Angel Mauricio Castro-Gamero Elton José Rosas de Vasconcelos Ricardo Santos de Oliveira Luciano Neder José Andres Yunes Simone dos Santos Aguiar Carlos Alberto Scrideli Luiz Gonzaga Tone 《Investigational new drugs》2017,35(1):124-124
62.
Kratz JM Andrighetti-Fröhner CR Leal PC Nunes RJ Yunes RA Trybala E Bergström T Barardi CR Simões CM 《Biological & pharmaceutical bulletin》2008,31(5):903-907
The synthetic n-alkyl esters of gallic acid, also known as gallates, are widely employed as antioxidants by food and pharmaceutical industries. Besides the antioxidant activity, other biological activities have been described for this group of molecules, mainly anticancer, antibacterial and antifungal properties. In the present study, the anti-herpes simplex virus (HSV)-2 activity of gallic acid and pentyl gallate was evaluated followed by the determination of the site of antiviral activity of these compounds. Our results demonstrated that both compounds reduced HSV-2 replication in a concentration-dependent manner when either incubated with the virus prior to the addition of the mixture to cells, or added to and incubated with cells after their infection. In summary, the anti-HSV-2 activity of gallic acid and pentyl gallate was ascribed to their virucidal effect on virus particles, a change that was likely accompanied by partial inhibition of the virus attachment to cells and its subsequent cell-to-cell spread activity. This suggests that these compounds can be regarded as promising candidates for development as topical anti-HSV-2 agents. 相似文献
63.
M. El Sayah V. Cechinel-Filho T. R. Pinheiro R. A. Yunes J. B. Calixto 《Inflammation research》1999,48(4):218-223
OBJECTIVE: This study describes the in vitro action of the hydroalcoholic extract and the 1,7-dihydroxy-2,3-dimethoxy xanthone isolated from P. cyparissias on agonist and ovalbumin induced contractions in trachea, from normal and actively sensitised guinea pigs. RESULTS: The hydroalcoholic extract of P. cyparissias (0.125 to 1 mg/ml), incubated with the guinea-pig trachea for 20 min, had no effect on the resting tone of the preparations, but caused a concentration-dependent, reversible and non competitive inhibition of contractions induced by acetylcholine, histamine, compound 48/80, bradykinin, substance P, prostaglandin E2 and the stable analogue of thromboxane A2 mimetic U 46619. The calculated mean IC50 values for the hydroalcoholic extract were: 0.37, 0.51, 0.06, 0.32, 0.48, 0.3 and 0.17 mg/ml, respectively. Also, the extract of P. cyparissias (0.125 to 0.5 mg/ml) antagonised, in a graded manner (IC50 of 0.46 mg/ml) ovalbumin-induced contractions in guinea-pig trachea obtained from animals which had been actively sensitised to this antigen. Pre-incubation of the preparations with the purifed xanthone isolated from P. cyparssias (2.5 to 80 microg/ml; 10.0 to 310.0 microM) caused significant and concentration-dependent, reversible and noncompetitive inhibition of the contractile responses elicited by acetylcholine, histamine, bradykinin, substance P, U 46619 and prostaglandin E2. The calculated mean IC50 values for these effects were: 132.0, 73.0, 9.2, 32.0, 110.6 and 66.0 microM, respectively. At very high concentrations (I55.0-620.0 microM) the xanthone also antagonised contraction induced by KCl in guinea-pig trachea (IC50 of 190.0 microM). CONCLUSIONS: Taken together these and our previous in vivo results are consistent with the view that the active principles present in P. cyparissias, including the 1,7-dihydroxy-2,3-dimethoxy xanthone, antagonise, in a non competitive but, reversible manner the contractions induced by chemical inflammatory mediators in the guinea pig trachea in vitro. Thus, these results might explain at least in part, the medicinal use of this plant in the management of inflammation, asthma and allergy. 相似文献
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66.
Lemes GA Kersanach R Pinto Lda S Dellagostin OA Yunes JS Matthiensen A 《Ecotoxicology and environmental safety》2008,69(3):358-365
Biological degradation of cyanobacterial hepatotoxin microcystins in estuarine and coastal water samples from the Patos Lagoon estuarine system, a coastal lagoon situated at the southernmost region of Brazil, was observed. Samples of natural surface water were spiked with purified and semi-purified microcystins (MC-LR and [D-Leu(1)]MC-LR) and their concentrations were monitored by HPLC analysis. After 15 days, the toxins were no longer detectable and after 43 days less than 90% of the initial concentration added to the samples was detected by ELISA. The average degradation rates and the exponential decay rate constants from inside and outside of the estuary were similar. A microcystin degradative bacterium was isolated from the estuarine region. Partial sequence of the 16S rDNA showed a 96% homology with the Burkholderia genus. This genus belongs to the beta subdivision on proteobacteria. This is the first report showing the genus Burkholderia as a cyanobacterial toxin degrader. 相似文献
67.
Venkat R. Ramachandran MS EE Issa M.S. Panahi PhD EE Ali A. Milani MS EE 《Journal of magnetic resonance imaging : JMRI》2010,31(1):46-55
Purpose:
To recover speech corrupted by functional magnetic resonance imaging (fMRI) acoustic noise using two‐channel adaptive speech enhancement techniques.Materials and Methods:
Speech corrupted by noise generated from a 3 T MRI scanner was recorded using diffuse‐field microphones and a data acquisition board. Multiband and subband adaptive speech enhancement methods are used to recover the speech signal from the recordings. Normalized least mean squares (NLMS) algorithm was used for updating the filter coefficients in each band.Results:
The methods are successful in enhancing the speech quality. They are successful in improving the convergence rate of the adaptive filter. Multiband and subband methods have a similar performance in terms of noise reduction and in the subjective tests. The subband method introduces less speech distortion compared to the multiband method. The subband method requires a lower number of computations per sample.Conclusion:
Adaptive speech enhancement techniques are effective in reducing fMRI background noise in the recordings. Based on the analysis, we conclude that subband‐based methods are more suited for enhancing speech corrupted by fMRI noise. J. Magn. Reson. Imaging 2010;31:46–55. © 2009 Wiley‐Liss, Inc. 相似文献68.
Correlates of methamphetamine use among young Iranians: Findings of a population‐based survey in 2013 下载免费PDF全文
69.
Shirin Panahi Adish Ezatagha Elena Jovanovski Alexandra Jenkins Feral Temelli Thava Vasanthan 《Journal of the American College of Nutrition》2013,32(6):442-449
Background: The blood glucose-lowering effects of β-glucan from oats and barley depend on the amounts consumed and their rheological properties. This has been recently challenged with growing evidence that the food matrix may also be an important factor in predicting its physiological response.Objective: The objective of this study was to examine the effects of varying doses of β-glucan from oats and barley and added to a snack bar on postprandial glycemia.Design: In a randomized crossover study, 12 healthy males and females consumed one of 8 snack bars containing 0 (control), 1.5, 3, and 6 g of β-glucan derived from oats or barley or 3 white bread controls. All treatments contained 50 g of available carbohydrate. Blood glucose concentrations were measured after ingestion of the treatments over 2 hours.Results: Incorporation of 1.5 to 6 g of β-glucan into snack bars had no additional glucose-lowering benefits irrespective of dose and source compared to the control bars (0 g β-glucan), suggesting that both the solid food matrix and composition of the bars may play a role in their effects on glycemic response. All bars reduced blood glucose area under the curve (AUC) by an average of 25% (p < 0.05) compared to the mean of the 3 white bread controls.Conclusion: Adding β-glucan from oats and barley to the snack bar formulation used in this study did not yield any additional benefits beyond the glucose-lowering effects of the snack bars themselves. 相似文献
70.
Zargari O Kimyai-Asadi A Fathalikhani F Panahi M 《International journal of dermatology》2003,42(8):608-612
BACKGROUND: Paederus dermatitis develops when beetles of the genus Paederus (often called rove beetles) are crushed on the skin, releasing the vesicant pederin. These beetles are found in many tropical and subtropical habitats. METHODS: We describe 156 patients who presented to a dermatology clinic in the Guilan province of northern Iran during a 6-month period (May-October 2001). RESULTS: The peak time of presentation was in September, and the face and neck were the most common sites of involvement. Clinically, the most common presentation comprised geographic erythematous plaques with micropustules. In three-quarters of patients, more than one lesion was present. Kissing lesions were seen in 5% of cases, and 15% of patients developed diffuse desquamation. The majority of patients resided within 1 km of rice fields and used fluorescent lighting at home. In half of the cases, another family member was also affected. CONCLUSIONS: Paederus dermatitis is a common skin condition in northern Iran. We believe that increased public awareness of this condition can decrease mucocutaneous exposure to pederin. 相似文献