全文获取类型
收费全文 | 1451篇 |
免费 | 67篇 |
国内免费 | 151篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 59篇 |
妇产科学 | 11篇 |
基础医学 | 134篇 |
口腔科学 | 28篇 |
临床医学 | 190篇 |
内科学 | 329篇 |
皮肤病学 | 48篇 |
神经病学 | 39篇 |
特种医学 | 341篇 |
外科学 | 70篇 |
综合类 | 24篇 |
预防医学 | 45篇 |
眼科学 | 20篇 |
药学 | 162篇 |
1篇 | |
中国医学 | 5篇 |
肿瘤学 | 160篇 |
出版年
2024年 | 1篇 |
2023年 | 7篇 |
2022年 | 2篇 |
2021年 | 21篇 |
2020年 | 17篇 |
2019年 | 15篇 |
2018年 | 24篇 |
2017年 | 23篇 |
2016年 | 21篇 |
2015年 | 29篇 |
2014年 | 52篇 |
2013年 | 52篇 |
2012年 | 63篇 |
2011年 | 55篇 |
2010年 | 52篇 |
2009年 | 52篇 |
2008年 | 50篇 |
2007年 | 137篇 |
2006年 | 53篇 |
2005年 | 50篇 |
2004年 | 21篇 |
2003年 | 12篇 |
2002年 | 28篇 |
2001年 | 35篇 |
2000年 | 15篇 |
1999年 | 26篇 |
1998年 | 78篇 |
1997年 | 77篇 |
1996年 | 71篇 |
1995年 | 63篇 |
1994年 | 43篇 |
1993年 | 52篇 |
1992年 | 9篇 |
1991年 | 17篇 |
1990年 | 12篇 |
1989年 | 55篇 |
1988年 | 31篇 |
1987年 | 33篇 |
1986年 | 27篇 |
1985年 | 23篇 |
1984年 | 21篇 |
1983年 | 14篇 |
1982年 | 29篇 |
1981年 | 15篇 |
1980年 | 18篇 |
1979年 | 7篇 |
1978年 | 4篇 |
1977年 | 16篇 |
1976年 | 28篇 |
1975年 | 13篇 |
排序方式: 共有1669条查询结果,搜索用时 312 毫秒
21.
22.
23.
SB Cho JH Kim S Cho JM Park YK Park SH Oh 《Journal of the European Academy of Dermatology and Venereology》2011,25(1):64-67
Background The clinical characteristics of vitiligo in children and adolescents with an emphasis on thyroid dysfunction have only been reported in a few studies. Objective The purpose of this study was to examine the characteristics of children and adolescents with vitiligo and compare the incidence of thyroid dysfunction between them and controls without vitiligo at the same age. Methods A retrospective analysis of 324 Korean children and adolescents with vitiligo was performed. The results of thyroid function screening tests in them (n = 254) were compared with controls (n = 122). Results Of the total 324 children and adolescents with vitiligo, vitiligo vulgaris was the most common type (42.3%) and the most commonly involved site was the face (54.6%). A total of 15 of 254 (5.9%) patients screened for thyroid function were diagnosed with thyroid disease (four had Hashimoto’s thyroiditis; two, Graves’ disease; seven, subclinical hypothyroidism; and two, subclinical hyperthyroidism). None of the 50 patients with segmental vitiligo showed any thyroid dysfunction (P = 0.047). There was no significant difference in the incidence of thyroid disease between children and adolescents with vitiligo and the control group, in which seven of 122 (5.7%) showed thyroid dysfunction. Conclusion In this study, we demonstrated the characteristics of children and adolescents with vitiligo and also observed no significant difference in the incidence of thyroid disease between children and adolescents with vitiligo and the control group. 相似文献
24.
25.
26.
Byung Woog Kang Jong Gwang Kim Yee Soo Chae Han Ik Bae Ohkyoung Kwon Ho Young Chung Wansik Yu Hong Suk Song Yu Na Kang Seung Wan Ryu Kyung Hee Lee Young Kyung Bae Joon Hyuk Choi Se Won Kim Hun‐Mo Ryoo Chang‐Ho Cho Hyun‐Dong Chae Kyun Woo Park Mi Jin Gu Byung‐Jo Bae 《Asia-Pacific Journal of Clinical Oncology》2014,10(2):e40-e45
27.
28.
29.
Jeong-Im Sin Jung-Min Kim Sung Hwa Bae In Hee Lee Jong Sup Park Hun Mo Ryoo 《Molecular therapy》2009,17(5):906-913
Adoptive cytotoxic T lymphocyte (CTL) therapy has an important implication in treating cancer patients. Here, we investigate whether adoptive transfer of human papillomavirus (HPV) E7-specific CTL can enhance tumor chemoresponse using an established cervical cancer animal model. Cisplatin-based chemotherapy plus CTL therapy showed an improved therapeutic effectiveness, along with antitumor protective responses to a parental tumor cell rechallenge. Cisplatin treatment dose-dependently increased the expression of Fas, intercellular adhesion molecule (ICAM)-1, and major histocompatibility complex (MHC) class I antigens (Ags) on tumor cells in vitro. However, CTL-expressing FasL failed to improve antitumor activity in vitro and in animals, resulting from nonfunctional Fas expressed on tumor cells. In contrast, ethylene glycol tetraacetic acid (EGTA) treatment blocked increased sensitivity of cisplatin-treated tumor cells to CTL-mediated killing in vitro, suggesting an important role of the perforin/granzyme-mediated pathway for improved therapeutic effectiveness. This notion was further confirmed by perforin knockout animal studies. Thus, this study shows that (i) modulation of Ag (Fas, ICAM-1) expression by tumor cells has little effect on their increased sensitivity to CTL-mediated killing, (ii) improved therapeutic effectiveness is mediated mainly through the perforin/granzyme-mediated tumor killing pathway, and (iii) a combination of chemotherapy and adoptive E7-specific CTL transfer augments antitumor therapeutic activity in vivo. This finding may have important implications for treating HPV-associated cervical cancer. 相似文献
30.