β-FIBRINOGEN PROMOTER-455 G／A （HaeⅢ） POLYMORPHISM PREDICTION OF PLASMA FIBRINOGEN BUT NOT OF ISCHEMIC CEREBROVASCULAR DISEASE

Objective The-455 G/A (HaeⅢ) polymorphism of β-fibrinogen gene influences levels of plasma fibrinogen. We further investigated whether it influences the risk of isehemie cerebrovaseular disease. Methods We accumulated 134 acute isehemic eerebrovaseular disease (ICVD) eases and compared their -455 G/A status with a control group (n=166). The β-fibrinogen gene -455 G/A polymorphism was analyzed for all subjects by PCR-RFLP with the restrictive enzyme HaeⅢ. Results Plasma fibrinogen was higher in AA homozygous participants (341mg/dL) than in participants carrying the G allele: GA (290mg/dL), GG (298mg/dL) in the control group. Plasma fibrinogen was also higher in AA homozygous patients (353mg/dL) than in eases carrying the G allele: GA (287mg/dL), GG (302mg/dL) in the ICVD group. However, there was no significant association between β-fibrinogen gene -455 G/A polymorphism and ICVD group. Conclusions Although a small effect cannot be excluded, β-fibrinogen gene -455 G/A polymorphism is an independent predictor of plasma fibrinogen, but not of isehemie cerebrovaacular disease.     

跟骨骨折的手术治疗

目的 探讨跟骨骨折手术治疗方法。方法 采用外侧切口，通过跟骨外侧骨皮质开门．将骨折复位后植骨．重建钢板螺钉内固定术．治疗24例（26足)。结果 术后均获5～32个月随访，按门振武等评分际准．优17例，良5例，差2例．结论 严重跟骨骨折手术治疗效果较满意。     

颞叶癫痫颅内EEG记录定位与海马病理变化的关系

目的探讨颞叶癫痫颅内EEG记录与颞叶海马病变程度的关系。方法视频EEG证实为颞叶癫痫并经MRI检查的病人序贯进入本研究,采用硬膜下电极及深部电极联合纪录,确定领先发作释放(initialictaldischarge,IID)部位。37例病人中,无或轻度海马萎缩(hippocampalatrophy,HA阴性组)27例,中至中度HA(HA阳性组)者10例。海马病理变化依据MRI检查的海马容积测量及术后组织病理学的海马硬化分级。结果本组HA阴性组27例病人中,9例病人IID广泛出现在海马区、内侧旧皮层及外侧新皮层;3例在海马区及内侧古皮层;14例完全出现在海马区以外的颞叶皮层;仅1例局限于海马区。在HA阳性组中,90%的病人IID局限于海马区(P<0.05),在25例低级别海马硬化(HS)中,IID局限于海马区显著低于12例HS高级别病人(P<0.05)。结论颞叶癫痫的抽搐发作放电定位与海马的病理变化存在着密切关系,无HA和低级别HS病人的IID多出现在海马、颞叶内侧皮层、颞叶新皮层的部位,而HA明显者和高级别的HS病人出现的IID往往仅局限于海马(HF)。     

假体隆乳术后并发症的防治

目的探讨乳房假体隆乳术后并发症产生的相关因素及预防方法。方法对198例患者乳房假体隆乳术后1~17年出现的并发症进行分析,阐述防治措施,针对不同情况进行相应的处理。结果本组198例患者,其中92例患者随访半年至1年,除Ⅲ°包膜挛缩患者术后仍出现Ⅱ~Ⅲ°包膜挛缩外(包膜松解术后3例,包膜切除术后4例),余患者对治疗效果满意。结论乳房假体隆乳术后出现的并发症,多数是可以预防和治疗的,只要术中操作规范,对并发症及早准确的处理,是提高手术效果,减少并发症发生的有效方法。     

浅谈药剂学的备课

由于长期从事药剂学的教学工作，在备教材、备学生这2个重要方面积累了一些经验：寻找教材中存在的问题，然后适当地处理教材；找准学生真实的学习起点，为学生设计自主学习的方式，以便于更好地实施教学。     

急性重复性缺氧小鼠脑组织中儿茶酚胺类神经递质含量变化的研究

用高效液相-电化学检测器测定急性重复性缺氧小鼠脑组织中DOPA、DA、NE和Ep等儿茶酚胺类物质的含量。结果发现:与空白对照组(A组)比较,缺氧1次的实验对照组(B组)及急性重复缺氧4次实验组(C组),随缺氧次数增加,小鼠脑组织中的DA含量显着上升(P<0.01),NE、DOPA含量明显降低(P<0.05或<0.01);A组与急性重复4次缺氧后饲养2d的实验对照组(D组)小鼠脑组织中儿茶酚胺类含量接近,没有统计学意义(P=23.77).结果提示脑组织中儿茶酚胺类物质可能参与急性重复缺氧小鼠的耐缺氧能力的形成,而且是一个可逆的快反应。     

D16S80和D16S125两位点RFLP在多囊肾症状前诊断中的应用

给出了用“混合型”雅可比级数的泰勒平均逼近黎普希兹函数类的点态估计。     

上海地区女性生殖道人乳头瘤病毒感染的检测

应用地高辛甙元标记人乳头瘤病毒(HPV)-6,11,16和18探针,通过核酸杂交法检测上海地区女性患者HPV的感染。计活检组织标本128例,阴道脱落细胞130例,同时取样34例。斑点杂交结果表明活检组织中四种类型HPV的总阳性率:宫颈癌44％,宫颈间变66.7％,有间变史28.6％,外阴尖锐湿疣63％和慢性宫颈炎5.6％。阴道脱落细胞的各阳性率与之相近,同时取样的检测符合率为91.2％。Southern转移杂交结果提示:宫颈癌以HPV-16型为主,尖锐湿疣中的HPV为6和11型     

Recent microsurgical advances in China

For more than two decades, microsurgery has been developed, practiced, and refined in China. For the most part, this has taken place independent of a parallel process in the Western World. Only until recent years has there been some communication from China regarding this microsurgical experience. The authors believe that there is much yet to be learned from the wealth of Chinese experience in microsurgery, just as Chinese surgeons have gained valuable information from the West. The authors reviewed the microsurgical literature in China from 1983 to 1986, and present here what we regard to be of particular interest to American microsurgeons, including the areas of digital reconstruction, replantation, flap transfer and transposition, and microsurgical techniques and patient management. Some historical background in the development of Chinese microsurgery is also provided.