治疗忧郁症有新招:维生素B很可能是重中之重

近日,研究人员声称分析了新的研究结果之后,发现那些忧郁症患者可能在维生素B的新陈代谢方面有问题,他们初步推断对维生素B的补充会有助于缓解这种病情。这群来自挪威的研究者发现那些血液中高半胱胺酸含量较普通人更高的人更容易患忧郁症。高半胱胺酸是人体内新陈代谢的产物,而叶酸是一种公认的酸性物质,它有助于分解高半胱胺酸。在接受路透社采访时,卑尔根大学的伊格瓦·本节兰IngvarBjelland博士声称叶酸的缺乏或者由此导致新陈代谢紊乱,从某种程度上会导致一些人患忧郁症。     

Apopotic gene Bax expression in carotid plaque

The expression of BAX in carotid atherosclcrosis and its regulation is far from defined. Objectives To investigate BAX expression in stable/fibrous and instable/vulnerable carotid plaque and its clinical significance. Methods 25 cases of carotid plaque specimens obtained from endarterectomy were divided into two groups, stable/fibrous 14 cases, vulnerable/instable 11 cases; aortic artery and its branches from hepatic transplantation donors 6 case as control. The expression of proapoptotic BAX was detected by immunohistochemistry (IHC), in situ hybridization(ISH) and in situ TdT dUTP nick end labeling (TUNEL). Results 5 eases of BAX ( ) were detected by ICH and ISH, 4 case of TUNEL ( ) were detected by TUNEL in stable/fibrous carotid plaque, while 10 cases were BAX ( )by IHC(P<0.05) , 11 case by ISH and 9 case by TUNEL were detected in instable/vulnerable carotid plaque (P<0.01), respectively. The intensity of BAX ( ) cells by IHC and ISH was 8.63±2.62 and 10.32±3.12 in fibrous plaques, whereas 122±21.64 and 152±23.35 in vulnerable plaques, respectively. No expression of BAX was found in controlled group. Conclusion The higher expression of Bax in vulnerable carotid plaque may be one mechanisms in molecular pathogenesis of carotid atherosclerosis which affect plaque stability and be the cause of higher incidence of stroke than fibrous carotid plaques, the regulation of BAX expression in different stage of atherosclerosis may provide targets in gene therapy for carotid atherosclerosis.     

瘤蒂征在MRI诊断小脑桥脑角听神经瘤中的价值

听神经瘤是小脑桥脑角的常见、多发肿瘤,但有时易与其他肿瘤混淆.本研究分析了19例经手术病理证实的小脑桥脑角听神经瘤MRI表现,探讨"瘤蒂征"对小脑桥脑角听神经瘤的诊断价值.     

β2-ADRENERGIC RECEPTOR GENE POLYMORPHISM IN CHINESE NORTHERN ASTHMATICS

THEβ2-adrenergicreceptor(β2-AR)ishighlyexpre-ssedonairwaysmoothmusclecellsinlung,anddefectsinβ2-ARsignalpathwaywereinvolvedinthepathogenesisofasthma.1 Humanβ2-ARgeneisanintr-onlessgenewithacodingblockconsistingof1239nucleo-tidesonchromosome5q31-32,genome-widesearchforas-thmasusceptibilitylocishowedthatmarkersonthisregionhavebeenlinkedtoasthma-associatedphenotypesinvariousethnicpopulations.2 Reihsausetal3 firstdescribedninecod-ingregionpolymorphisms,particularly,thethreecommonaminoacidsu…     

模拟乡村医生考试综合试卷二(上)

A型试题 1.神经-骨骼肌接头处的化学递质是: A.多巴胺 B.去甲肾上腺素 C.肾上腺素 D.乙酰胆碱 E.血管活性肠肽 2.心肌在兴奋变化时所表现出的特点是: A.绝对小应期短 B.相对不应期短 C.有效不应期特别长 D.超常期特别长 E.低常期较长 3.维持胸腔内负压的必要条件     

推拿治疗小儿寰枢椎半脱位

寰枢椎半脱位系寰椎横韧带损伤或失稳导致寰椎向前或旋转移位。此病多见于儿童,如不及时治疗,会导致斜颈和面部发育不对称等终生痛苦。目前治疗方法有枕颏套牵引,复位后支架或石膏固定,以及寰枢椎融合术,但上述方法都不易取得患者配合,影响疗效。我们采用稳、准、轻巧的技术在短时间内达到寰枢关节解剖复位。现将40例的治疗报道如下。