君复康胶囊治疗帕金森病的临床研究

目的 评价君复康胶囊治疗帕金森病PD的价值。方法 选取44例符合PD诊断标准的PD患者，服用抗震颤药物2年以上。君复康组30例，美多巴组14例作为对照。治疗前后进行UPDRS评分。美多巴组和君复康组患者皆口服美多巴片连续服用6个月，君复康组除服用美多巴外，加用口服君复康胶囊连续服用6个月。结果 美多巴组治疗前后的UPDRS无显著差异（P〉0．05）；君复康组差异非常显著（P〈0．01）。美多巴组总有效率为35．7l％，君复康组总有效率为70％。两组间差异显著（χ^2=4．642，P〈0．05）。结论 君复康胶囊是治疗PD的有效辅助制剂。     

结直肠癌与息肉组织中Cyclin A和D1阳性细胞比例的比较

结直肠癌和结直肠息肉均为细胞增生性疾病,但前者为失控性生长,后者属于限制性生长。资料表明大多数结直肠癌来自腺瘤样息肉[1] 。为探索两者增生过程中细胞周期调控机制的改变,我们对结直肠癌与息肉组织中的细胞周期素A和D1 (Cy clinA、D1 )阳性细胞比例进行了检测、比较和分析。材料和方法1 .标本来源:所有标本均取自我院2 0 0 1年5月以来经常规病理诊断为乙状结肠、直肠息肉和乙状结肠、直肠癌病人的标本。结直肠息肉病人5 1例,平均年龄35 .7岁(2 5～6 8岁) ,男35例,女1 6例。位于乙状结肠2 1例,直肠30例。单个或2个息肉者39例,3个或3…     

APPLICATION OF SINGLE PHOTON EMMISSION COMPUTED TOMOGRAPHY TO CLINICAL STUDY ON THE THERAPEUTIC EFFECT OF ACUPUNCTURE IN TREATMENT OF CHILD CEREBRAL PARALYSIS

Subjective: To identify the practicability and clinical values of acupuncture in the treatment of child cerebral paralysis, try to provide visualized evidence and mechanisms for acupuncture treatment of this disease. Methods: 13 cerebral palsy children including 9 cases of spasmodic type, 2 cases of ataxia type and 2 cases of mixed type, 9 males and 4 females were subjected into this study. Acupoints used were Hegu (LI 4), Quchi (LI 11 ), Zusanli (ST 36) and Sanyinjiao (SP 6) that were punctured and stimulated electrically with parameters of frequency 2/15 Hz, electric current 5 mA, and duration of stimulation 30 min. Under monitoring of Siemens ECAM/ICON SPECT System, blood flow volumes of different brain regions were observed before, during and after elctroacupuncture (EA) stimulation of the above-mentioned acupoints. Results: SPECT revealed that in these 13 infantile patients, 18 regions of the brain in-cluding 12 in the frontal lobe and 6 in the temporal lobe presented insufficiency of blood perfusion and hypofunction; during EA, these cerebral regions and parietal lobe, visual cortex, thalamus, basal ganglion and cerebellum showed improvement in blood perfusion and function in different degrees. Results of the quantitative analysis on blood flow function changing rate (BFCR)% showed a significant increase in 83.3 % of the focal regions during EA. Conclusion: Acupuncture therapy can effectively improve cerebral blood perfusion of the focus and is of clinical value in treatment of infantile cerebral paralysis.     

高压氧治疗新生儿缺氧缺血性脑病的疗效分析

目的　观察分析高压氧（ＨＢＯ）治疗及常规治疗新生儿缺氧缺血性脑病（ｈｙｐｏｘｉｃ ｉｓｃｈｅｍ ｉｃｅｎｃｅｐｈａｌｏｐａｔｈｙ,ＨＩＥ）的疗效。方法　ＨＢＯ治疗组４８例,给予ＨＢＯ及常规护脑、对症治疗;治疗绝对压为０．１３～０．１５ ＭＰａ,氧浓度为６５％ ～９０％ ,每次６０～８０ 分钟（以上３ 项条件视年龄大小而异）,每天治疗１ 次,１０ 次为１ 个疗程,一般为１～２ 个疗程。常规治疗组４１ 例,给予常压下吸氧及同样护脑、对症治疗。结果　ＨＢＯ治疗组疗效为：显效１８ 例（３７．５％ ）,有效２７ 例（５６．２５％ ）、无效３ 例（６．２５％ ）,总有效率为９３．７５％ 。常规治疗组疗效为：显效８ 例（１９．５１％ ）,有效２４例（５８．５４％ ）、无效９ 例（２１．９５％ ）,总有效率为７８．０５％ 。两组显效率相比较,χ２ ＝ ３．８８　Ｐ＜ ０．０５;总有效率相比较,χ２ ＝ ４．７４　Ｐ＜ ０．０５,均有显著差异性。结论　对ＨＩＥ治疗的ＨＢＯ 治疗组疗效优于常规治疗组。     

高压氧对新生儿缺氧缺血性脑病血浆ET、CGRP、6-keto-PGF_(1α)及TXB_2浓度的影响

目的　探讨高压氧（ＨＢＯ）对新生儿缺氧缺血性脑病（ＨＩＥ）患者血浆内皮素（ＥＴ）、降钙素基因相关肽（ＣＧＲＰ）、前列环素（６－ｋｅｔｏ－ＰＧＦ１α）及血栓素Ｂ２ （ＴＸＢ２ ）浓度的影响。方法　ＨＢＯ组２０ 例,给予ＨＢＯ 及常规治疗;对照组２７ 例,只给常规治疗。ＨＢＯ 治疗使用透明单人氧舱,绝对压力为０．１３～０．１５ ＭＰａ,氧浓度为６５％ ～９０％ ,每次１ 小时,每天１ 次,１０ 次为１ 个疗程（一般进行１～２ 个疗程）;于患者出生第３ 天开始ＨＢＯ治疗。治疗前、出生后第５ 天及第９ 天分别取静脉血用放射免疫法测ＥＴ、ＣＧＲＰ、６－ｋｅｔｏ－ＰＧＦ１α及ＴＸＢ２ 浓度。结果　发现ＣＧＲＰ随新生儿出生后日龄增长,血浓度减低;但ＨＢＯ对ＥＴ、ＣＧＲＰ、６－ｋｅｔｏ－ＰＧＦ１α及ＴＸＢ２ 浓度无明显影响。结论　ＣＧＲＰ可能参与ＨＩＥ的病理生理过程,而ＨＢＯ治疗ＨＩＥ主要是通过其它机制发挥作用。