五味子素对四氯化碳染毒小鼠促进肝线粒体谷胱甘肽抗氧化状态的 …

AIM: To explore whether the methylenedioxy group and cyclooctadiene ring of the dibenzocyclooctadiene skeleton of schisandrins (Sch) play a role in the liver mitochondrial glutathione status enhancing activity. METHOD: The effects of three dibenzocyclooctadiene derivatives, Sch A, Sch B, Sch C, and a synthetic intermediate of Sch C, (dimethyl biphenyl dicarboxylate, DBD) on carbon tetrachloride (CCl4)-hepatotoxicity and liver mitochondrial glutathione status were examined in mice. RESULTS: Pretreating mice with intragastric Sch B, Sch C, or DBD 1.mmol.kg-1.d-1 for 3 d protected against CCl4-hepatotoxicity. The hepatoprotection afforded by Sch B or Sch C pretreatment was associated with increases in liver mitochondrial reduced glutathione (mtGSH) level and glutathione reductase (mtGRD) activity, an indication of enhanced mitochondrial glutathione status. In contrast, the hepatoprotective action of DBD was not accompanied by any detectable changes in mtGSH level and mtGRD activity. CONCLUSION: Both the methylenedioxy group and the cyclooctadiene ring of the dibenzocyclooctadiene molecule are important structural determinants in the enhancement of liver mitochondrial glutathione status.     

131例小儿急性黄疸型肝炎血清前白蛋白的测定

采用免疫扩散技术检测131例小儿急性黄疸型肝炎血清前白蛋白(PA),同时检测SGPT,其中急     

MALIGNANT BONE FIBR.OUS HISTIOCYTOMA REPORT OF 3 CASES

Three ca.ses of malignant bone fibrous his- tiocytoma are reported. They were identified on the basis of charact.eristic histopathologic fea.- tures, i.e. neoplastic histiocytes, fibroblast-like cells and multinuclear or mononuclear tumor giant cells, generally appearing very pleomorphic and bizarre and fibroblastic cells and collagen fibers arranged in storiform or matted fashion, as well as active phagocytosis, prominent mitosis and sprinkling of lymphocytes and plasma cell infiltration. The storiform pattern is considered the most characteristic feature, which may be of great help in differential diagnosis. The clinical manifestations, roentgenologic pictures and sur- gery results in 3 cases are also described.     

溃疡性结肠炎组织中粘际分子CD54,CD44的检测

为研究粘附分子在溃疡性结肠炎发病机制中的作用，应用流式的细胞订测定３４例ＵＣ患者活检组织及血液中粘附分子ＣＤ４４及细胞间粘附分子ＣＤ５４，并与２０例正常人对照。结果显示，ＵＣ患者组织和血液中ＣＤ４４、ＣＤ５４较正常人明显升高，缓解期ＵＣ患者上述指标较活动期显著下降，但仍明显高于正常人。本文结果显示粘附分子水平增加在ＵＣ的发病机制中起重要作用，对判断或监测ＵＣ患者病情进展及活动转归具有一定意义。     

两种鼻窦置换方法的临床对照

目的通过观察改良的鼻窦置换方法治疗慢性鼻窦炎的效果，探讨改良鼻窦置换方法的临床应用价值。方法将80例慢性全组鼻窦炎患者随机分为传统鼻窦置换组(A组)和改良鼻窦置换组(B组)各40例，观察治疗前后患者的自觉症状、临床表现和CT结果。结果治疗后两组患者的症状均有改善，A组治愈5例(12．5％)，总有效30例(75．0％)。B组治愈26例(65．0％)，总有效40例(100．0％)。结论通过对鼻窦置换方法的改进，可以提高慢性鼻窦炎的治疗效果。     

Apofix椎板夹内固定在寰枢椎不稳治疗中的应用

目的探讨Apofix椎板夹内固定在寰枢椎不稳治疗中的应用价值。方法2000年4月至2004年7月,在颈后路切开复位手术中采用Apofix椎板夹内固定植骨融合治疗寰枢椎不稳30例。男24例,女6例;年龄19～67岁,平均41岁。寰枢椎脱位5例,齿突骨折25例。齿突骨折中有新鲜骨折21例,陈旧骨折、骨不连4例;AndersonⅡ型骨折23例,Ⅲ型骨折2例。颅骨牵引复位后,于术中显露寰枕间隙、寰椎后弓及枢椎椎板,置入Apofix椎板夹的上、下椎板钩。将取自髂骨的植骨块植入C1,2椎板间隙,夹紧连接杆完成固定。结果全部病例随访8～46个月,平均27个月。颈椎完全复位28例,不完全复位2例。术中平均出血65ml,手术时间70￣150min。术后颈围保护下坐起时间平均为术后第3天(第2～6天),无脊髓损伤或损伤较轻者离床活动时间平均为术后第7天(第2～10天)。术后3个月植骨融合。术前合并神经系统症状者16例,术后5例上颈椎神经根压迫症状消失或基本消失;11例脊髓损伤者术后脊髓功能均有不同程度改善,Frankel分级提高2级1例、1级8例、2例无变化。未发生椎动脉、神经根、脊髓损伤或脊髓损伤加重等严重并发症。结论Apofix椎板夹内固定具有操作简便、安全可靠等特点,为颈后路内固定提供了一种安全、有效的方法。     

真两性畸形合并腹膜外子宫一例报告

报道一例28岁,社会性別为女性的真两性畸形患者。经手术证实为真两性畸形合并腹膜外子宫,左侧输卵管发育不全,右侧卵睾,小阴唇和阴道发育不全,染色本核型是46,XX/46,XY。治疗采用睾丸切徐和阴道成形术,获得成功。