全文获取类型
收费全文 | 1409篇 |
免费 | 13篇 |
国内免费 | 714篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 21篇 |
妇产科学 | 9篇 |
基础医学 | 33篇 |
口腔科学 | 3篇 |
临床医学 | 233篇 |
内科学 | 420篇 |
皮肤病学 | 23篇 |
神经病学 | 31篇 |
特种医学 | 6篇 |
外科学 | 243篇 |
综合类 | 774篇 |
一般理论 | 1篇 |
预防医学 | 104篇 |
药学 | 210篇 |
中国医学 | 1篇 |
肿瘤学 | 21篇 |
出版年
2015年 | 32篇 |
2014年 | 24篇 |
2013年 | 18篇 |
2012年 | 32篇 |
2011年 | 38篇 |
2010年 | 60篇 |
2009年 | 346篇 |
2008年 | 67篇 |
2007年 | 79篇 |
2006年 | 89篇 |
2005年 | 32篇 |
2004年 | 29篇 |
2003年 | 6篇 |
2002年 | 16篇 |
2001年 | 39篇 |
2000年 | 15篇 |
1999年 | 34篇 |
1998年 | 41篇 |
1997年 | 20篇 |
1996年 | 27篇 |
1995年 | 29篇 |
1994年 | 26篇 |
1993年 | 14篇 |
1992年 | 7篇 |
1991年 | 8篇 |
1990年 | 9篇 |
1989年 | 7篇 |
1987年 | 8篇 |
1986年 | 16篇 |
1985年 | 8篇 |
1966年 | 47篇 |
1965年 | 130篇 |
1964年 | 71篇 |
1963年 | 144篇 |
1962年 | 64篇 |
1960年 | 51篇 |
1959年 | 40篇 |
1958年 | 39篇 |
1957年 | 70篇 |
1956年 | 48篇 |
1954年 | 22篇 |
1941年 | 27篇 |
1940年 | 21篇 |
1939年 | 17篇 |
1938年 | 13篇 |
1936年 | 28篇 |
1935年 | 22篇 |
1933年 | 12篇 |
1932年 | 7篇 |
1931年 | 15篇 |
排序方式: 共有2136条查询结果,搜索用时 15 毫秒
1.
TOBIAS HUND MD BENJAMIN ASCHER MD BERTHOLD RZANY MD SCM FOR THE SMILE STUDY GROUP 《Dermatologic surgery》2006,32(10):1256-1260
BACKGROUND: Several clinical scoring systems have been used to evaluate the efficacy of botulinum toxin A in the treatment of hyperkinetic wrinkles. So far very few have been investigated for their reproducibility. OBJECTIVE: The aim of this study was to investigate the reproducibility of two clinical four-point scales for lateral canthal lines (crow's feet), at rest and at maximum smile. MATERIAL AND METHODS: Based on standardized photographs, a consensus atlas depicting the different severity grades [from 0 (none) to 3 (severe)] was developed. After training based on the atlas, 49 photographs at rest and 48 at maximum smile were graded by the same group of investigators on 2 consecutive days (n=9 on Day 1; n=8 on Day 2). The scores were compared for reproducibility using kappa statistics. RESULTS: Overall, reproducibility was good for both scales. Interobserver reproducibility showed an agreement of 0.6 at rest and 0.58 at maximum smile (unweighted kappa). Intraobserver reproducibility showed an agreement between 0.47 and 0.86 at rest and between 0.62 and 0.81 at maximum smile (unweighted kappa). Using weighted kappa analysis, the agreement ranged between 0.63 and 0.91 at rest and between 0.71 and 0.85 at maximum smile. CONCLUSION: The clinical scales using scores of 0 to 3 for crow's feet, both at rest and at maximum smile, show a good inter- and intraobserver reproducibility. The use of these scores in clinical trials can be recommended. 相似文献
2.
3.
4.
The purpose of the pre~ent paper is to review certain aspects of
catarrhal jaundice and arsenical jaundice and their relation to acute
yellow atrophy in connection with a case of diffuse liver degeneration
following neo-arsphenamine and mapharsen treatment with rapid fatal
termination. Such a review may serve to clarify our present position
in regard to the pathogenesis of catarrhal jaundice and arsenical
jaundice. The case is remarkable in that the liver remained Iarge to
the end in spite of the fulminating course. 相似文献
5.
After a comprehensive rernew of the literature on syphilitic
aortitis, Longcope, (1) stated in 1913; ": . . . the presence of spiro:
chetes in these lesions, as might be expected, cannot by any means be
constantly demonstrated with Levaaiti stain. . . . . . . That these
organisms are ''Treponema pallidum seems almost certain thouS:h actual
proof of such by culture from the arterial lesions, a most difficult task,
or direct inoculation into animals, has not as yet been accomplished." 相似文献
6.
Effect of metoprolol on death and cardiac events during a 2-year period after coronary artery bypass grafting 总被引:1,自引:0,他引:1
PURPOSE: To evaluate the effect of long-term treatment with metoprololafter coronary bypass grafting on death and cardiac events. METHODS: Patients in western Sweden on whom coronary artery bypass graftingwas performed between June 1988 and June 1991 were evaluatedfor inclusion during the first 3 weeks after surgery. Majorexclusion criteria were age >75 years, concomitant valvesurgery, traditional contraindications to beta-blockers andunwillingness to participate. Patients were randomized in adouble-blind fashion to 100 mg of metoprolollplacebo daily for2 weeks and thereafter 200 mg daily for 2 years. RESULTS: Of 2365 patients who were operated on, 967 were randomized toeither metoprolol (n=480) or placebo (n=487). Primary end points(death, non-fatal myocardial infarction, unstable angina pectoris,need for coronary artery bypass grafting or percutaneous transluminalangioplasty), were reached by 42 patients in the metoprololgroup (8·8%) as compared with 39 in the placebo group(8·0%) (P=0·73). Of all the patients randomizedto metoprolol, 34% withdrew from blind treatment prematurelycompared with 44% for placebo (P<0·01) CONCLUSION: Prophylactic treatment with metoprolol over a 2-year periodafter coronary artery bypass grafting did not reduce death orthe development of cardiac events. However, the 95% confidencelimits ranged from the possibility of a 30% reduction in eventsto a 68% increase in events if patients were treated with metoprololas compared with placebo. 相似文献
7.
Objective To identify the direct causes of drug relapse and abstainers’ demand, and to develop programs for the prevention of drug relapse. Methods Abstainers in a Compulsive Detoxification Center in Wuhan City, capital of Hubei Province were randomly selected. An investigation on the direct causes of drug relapse and abstainers’ demands was conducted with multiple-choice questionnaires and face to face interviews. Data were analyzed with SPSS 12.0. Results The direct causes leading to drug relapse included: temptation to use drug again by themselves or by their drug mates, seeking pleasure and ecstasy from drug use, relatively well off living, mental stress, irritation, demoralization, family conflicts, unemployment, feeling distrusted by the family, lack of care and love from the family, and discrimination by others. abstainers’ demands after detoxification and returning to the society included: care and support from the family, employment assistance, changing living environment, understanding by others, support from the society, and keeping far away from drugs. Conclusions Environmental factors are the direct causes of drug relapse, and negative irritation is its predisposing causes. Leaving former residence, more care and help given by both the family and the society and raising their overall quality of life are the demands of abstainers. 相似文献
8.
YUKIO HOMMA HIDEYUKI AKAZA KIYOKI OKADA MASAO YOKOYAMA MICHIYUKI USAMI YOSHIHIKO HIRAO TOMOYASU TSUSHIMA ATSUHIKO SAKAMOTO YASUO OHASHI YOSHIO ASO THE PROSTATE CANCER STUDY GROUP 《International journal of urology》2004,11(4):218-224
BACKGROUND: We retrospectively compared the 5-year survival rates of T1b-T3N0M0 prostate cancer patients treated either by endocrine therapy plus radical prostatectomy or endocrine therapy alone. METHODS: Clinical T1b-T3N0M0 prostate cancer patients were enrolled at 104 institutions in Japan. They were assigned to study 1 (n = 176), if they were indicated to prostatectomy, if not indicated, they were assigned to study 2 (n = 151). The indication of prostatectomy was based on the clinical judgement of physicians and/or patients. Those assigned to study 1 underwent prostatectomy and adjuvant endocrine therapy with or without preoperative androgen deprivation. Those assigned to study 2 were treated with leuprorelin acetate with or without chlormadinone acetate. They were followed-up every 3 months until death or for 5 years and over. RESULTS: Those assigned to study 1 were younger (mean age 67.2 vs 75.7 years), less advanced in clinical stage, and had lower prostate specific antigen levels (mean 43.8 vs 103.6 ng/mL). Death for any reason was observed less frequently in study 1 (n = 29, 16%) than study 2 (n = 50, 33%), and the 5-year overall survival rate was higher in study 1 (87 vs. 68%). However, prostate cancer deaths were comparatively seldom (9% in study 1 and 7% in study 2), resulting in the identical 5-year cause specific survival rate in both study groups (91%). In both study groups the overall survival was almost equal to the natural survival of age-matched men. CONCLUSIONS: Endocrine therapy offers a reasonable survival rate in T1b-T3 prostate cancer patients within a 5-year follow-up. Observation will be extended to determine 10-year outcomes. 相似文献
9.
Divisiort of Neuropsychiatry of Department of Medtczne and Department o/
Pharmacology, Natio礼ul rVedicat Ooltege of Shtrnghai, Shanghai, China. .
As far as the writers are aware, few studies on the changes of
blood and cerebrospinal fiuid sugar during hypoglycemia have been
made in schizophrenic patients. While our work was in progress, two
articles had come to our notice. In the paper by Dussik (1) the
blood and cerebrospinal fluid sugar values at the time of insulm coma
were determined, while in the communication by Day, Niver and
Greenberg (2) the course of changes in blood ar.d cerebrospinal fIuid
sugar after insulin was followed. The object of this paper is to
report the results of a number of individual and serial determinations
of both the bIood and cerebrospinal fluid sugar in schizophrenic
patients treated by insulin according to Sakel''s method (3). 相似文献
10.
Influence of Chemical Oxygen Demand Concentrations on Anaerobic Ammonium Oxidation by Granular Sludge From EGSB Reactor 总被引:1,自引:0,他引:1
JING KANG JIAN-LONG WANG? Laboratory of Environmental Technology INET Tsinghua University Beijing China 《Biomedical and environmental sciences : BES》2006,(3)
INTRODUCTION The phenomenon of anaerobic ammonium oxidation was originally discovered in a denitrifying fluidized-bed reactor treating effluent from a methanogenic reactor in the 1990s[1]. Anaerobic ammonium oxidation (ANAMMOX) process is a strictly anaerobic denitrification process, in which ANAMMOX autotrophic bacteria directly oxidize ammonium to dinitrogen gas using nitrite as electron acceptor. In recent years, the anammox process has received great attention and lots of researc… 相似文献