全文获取类型
收费全文 | 1131篇 |
免费 | 93篇 |
国内免费 | 62篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 47篇 |
妇产科学 | 11篇 |
基础医学 | 133篇 |
口腔科学 | 14篇 |
临床医学 | 154篇 |
内科学 | 188篇 |
皮肤病学 | 26篇 |
神经病学 | 47篇 |
特种医学 | 112篇 |
外科学 | 103篇 |
综合类 | 63篇 |
预防医学 | 81篇 |
眼科学 | 109篇 |
药学 | 92篇 |
1篇 | |
中国医学 | 2篇 |
肿瘤学 | 84篇 |
出版年
2023年 | 6篇 |
2022年 | 7篇 |
2021年 | 43篇 |
2020年 | 19篇 |
2019年 | 32篇 |
2018年 | 39篇 |
2017年 | 22篇 |
2016年 | 20篇 |
2015年 | 30篇 |
2014年 | 31篇 |
2013年 | 46篇 |
2012年 | 52篇 |
2011年 | 34篇 |
2010年 | 35篇 |
2009年 | 40篇 |
2008年 | 35篇 |
2007年 | 79篇 |
2006年 | 65篇 |
2005年 | 48篇 |
2004年 | 29篇 |
2003年 | 31篇 |
2002年 | 39篇 |
2001年 | 27篇 |
2000年 | 28篇 |
1999年 | 29篇 |
1998年 | 31篇 |
1997年 | 45篇 |
1996年 | 32篇 |
1995年 | 29篇 |
1994年 | 19篇 |
1993年 | 30篇 |
1992年 | 8篇 |
1991年 | 15篇 |
1990年 | 23篇 |
1989年 | 34篇 |
1988年 | 17篇 |
1987年 | 21篇 |
1986年 | 12篇 |
1985年 | 9篇 |
1984年 | 11篇 |
1983年 | 6篇 |
1982年 | 7篇 |
1981年 | 5篇 |
1980年 | 12篇 |
1979年 | 9篇 |
1978年 | 7篇 |
1976年 | 5篇 |
1975年 | 5篇 |
1974年 | 6篇 |
1969年 | 5篇 |
排序方式: 共有1286条查询结果,搜索用时 15 毫秒
11.
Peter Appelros Gunnel M Karlsson Annika Thorwalls Kerstin Tham Ingegerd Nydevik 《Journal of rehabilitation medicine》2004,36(6):258-261
OBJECTIVE: The Baking Tray Task is a comprehensible, simple-to-perform test for use in assessing unilateral neglect. The aim of this study was to validate further its use with stroke patients. METHODS: The Baking Tray Task was compared with 2 versions of the Behaviour Inattention Test and a test for personal neglect. A total of 270 patients were subjected to a 3-item version of the Behaviour Inattention Test and 40 patients were subjected to an 8-item version of the Behaviour Inattention Test, besides the Baking Tray Task and the personal neglect test. RESULTS: The Baking Tray Task was more sensitive than the 3-item Behaviour Inattention Test, but the 8-item Behaviour Inattention Test was more sensitive than the Baking Tray Task. The best combination of any 3 tests was Baking Tray Task, Reading an article, and Figure copying; the 2 last-mentioned being a part of the 8-item Behaviour Inattention Test. CONCLUSION: Multi-item tests detect more cases of neglect than do single tests. However, it is tiresome for the patient to undergo a larger test battery than necessary. It is also time-consuming for the staff. Behavioural tests seem more appropriate when assessing neglect. The Baking Tray Task seems to be one of the most sensitive single tests, but its sensitivity can be further enhanced when it is used in combination with other tests. 相似文献
12.
13.
A double-blinded study was conducted to compare the effects of mupirocin and tetracycline ointments in the treatment of skin infections. 111 patients were available for clinical assessment, of which 53 were treated with mupirocin and 58 treated with tetracycline. Clinically, both groups were improved, and there was no significant difference. Bacteriological assessment however revealed a better response to mupirocin. Staphylococcus aureus and Streptococcus pyogenes were the most common organisms isolated. 99% of Staphylococci were sensitive to mupirocin compared with 61% to tetracycline and 29% to penicillin G. 57% of Group A beta haemolytic Streptococci were resistant to tetracycline compared to 14% to mupirocin. Gram-negative organisms were mostly resistant to both preparations. No side effects were observed in both treatment groups. This study suggests that mupirocin is a safe and effective topical preparation for treating most of our common skin infections. 相似文献
14.
Randomised controlled trial of ranitidine versus omeprazole in combination with antibiotics for eradication of Helicobacter pylori. 总被引:2,自引:0,他引:2 下载免费PDF全文
T. C. Tham J. S. Collins C. Molloy J. M. Sloan K. B. Bamford R. G. Watson 《The Ulster medical journal》1996,65(2):131-136
This study compared high dose ranitidine versus low dose omeprazole with antibiotics for the eradication of H pylori. 80 patients (mean age 48 years, range 18-75) who had H pylori infection were randomised in an investigator-blind manner to either a two-week regime of omeprazole 20 mg daily, amoxycillin 500 mg tid and metronidazole 400 mg tid (OAM), or ranitidine 600 mg bd, amoxycillin 500 mg tid and metronidazole 400 mg tid (RAM), or omeprazole 20 mg daily and clarithromycin 500 mg tid (OC), or omeprazole 20 mg daily and placebo (OP). H pylori was eradicated in 6 of 19 patients in the OAM group (32%); 8 of 18 in the RAM group (44%), 4 of 15 in the OC group (27%); none of 18 in the OP group (0%). [< P0.005 for OAM, RAM, OC vs OP; P = N.S. between OAM, RAM, OC]. Overall metronidazole resistance was unexpectedly high at 58%. Eradication rates in metronidazole sensitive patients were 71% (5/7) and 100% (3/3) for OAM and RAM respectively. In conclusion, H pylori eradication rates using high dose ranitidine plus amoxycillin and metronidazole may be similar to that of low dose omeprazole in combination with the same antibiotics for omeprazole with clarithromycin. Overall eradication rates were low due to a high incidence of metronidazole resistance but were higher in metronidazole-sensitive patients. Even high dose ranitidine with two antibiotics achieves a relatively low eradication rate. These metronidazole-based regimens cannot be recommended in areas with a high incidence of metronidazole resistance. 相似文献
15.
Background
There is currently an unprecedented expressed need and demand for estimates of maternal mortality in developing countries. This has been stimulated in part by the creation of a Millennium Development Goal that will be judged partly on the basis of reductions in maternal mortality by 2015. 相似文献16.
17.
Experimental Infection of Mongolian Gerbils with Wild-Type and Mutant Helicobacter pylori Strains 总被引:12,自引:0,他引:12 下载免费PDF全文
Hans-Peter Wirth Michael H. Beins Manqiao Yang Kyi T. Tham Martin J. Blaser 《Infection and immunity》1998,66(10):4856-4866
Experimental Helicobacter pylori infection was studied in Mongolian gerbils with fresh human isolates that carry or do not carry cagA (cagA-positive or cagA-negative, respectively), multiply passaged laboratory strains, wild-type strain G1.1, or isogenic ureA, cagA, or vacA mutants of G1.1. Animals were sacrificed 1 to 32 weeks after challenge, the stomach was removed from each animal for quantitative culture, urease test, and histologic testing, and blood was collected for antibody determinations. No colonization occurred after ≥20 in vitro passages of wild-type strain G1.1 or with the ureA mutant of G1.1. In contrast, infection occurred in animals challenged with wild-type G1.1 (99 of 101 animals) or the cagA (25 of 25) or vacA (25 of 29) mutant of G1.1. Infection with G1.1 persisted for at least 8 months. All 15 animals challenged with any of three fresh human cagA-positive isolates became infected, in contrast to only 6 (23%) of 26 animals challenged with one of four fresh human cagA-negative isolates (P < 0.001). Similar to infection in humans, H. pylori colonization of gerbils induced gastric inflammation and a systemic antibody response to H. pylori antigens. These data confirm the utility of gerbils as an animal model of H. pylori infection and indicate the importance of bacterial strain characteristics for successful infection. 相似文献
18.
19.
The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry 总被引:8,自引:1,他引:8
Nistico L; Buzzetti R; Pritchard LE; Van der Auwera B; Giovannini C; Bosi E; Larrad MT; Rios MS; Chow CC; Cockram CS; Jacobs K; Mijovic C; Bain SC; Barnett AH; Vandewalle CL; Schuit F; Gorus FK; Tosi R; Pozzilli P; Todd JA 《Human molecular genetics》1996,5(7):1075-1080
Susceptibility to autoimmune insulin-dependent (type 1) diabetes mellitus
is determined by a combination of environmental and genetic factors, which
include variation in MHC genes on chromosome 6p21 (IDDM1) and the insulin
gene on chromosome 11p15 (IDDM2). However, linkage to IDDM1 and IDDM2
cannot explain the clustering of type 1 diabetes in families, and a role
for other genes is inferred. In the present report we describe linkage and
association of type 1 diabetes to the CTLA-4 gene (cytotoxic T lymphocyte
associated-4) on chromosome 2q33 (designated IDDM12). CTLA-4 is a strong
candidate gene for T cell- mediated autoimmune disease because it encodes a
T cell receptor that mediates T cell apoptosis and is a vital negative
regulator of T cell activation. In addition, we provide supporting evidence
that CTLA-4 is associated with susceptibility to Graves' disease, another
organ- specific autoimmune disease.
相似文献
20.